EA200601393A1 - Способ получения (r)-(-)-5(2-аминопропил)-2-метоксибензолсульфонамида - Google Patents

Способ получения (r)-(-)-5(2-аминопропил)-2-метоксибензолсульфонамида

Info

Publication number
EA200601393A1
EA200601393A1 EA200601393A EA200601393A EA200601393A1 EA 200601393 A1 EA200601393 A1 EA 200601393A1 EA 200601393 A EA200601393 A EA 200601393A EA 200601393 A EA200601393 A EA 200601393A EA 200601393 A1 EA200601393 A1 EA 200601393A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
aminopropil
methoxybenzenesulphonamide
obtaining
resulting
Prior art date
Application number
EA200601393A
Other languages
English (en)
Other versions
EA010131B1 (ru
Inventor
Йосеф Гаицек
Маркета Славикова
Original Assignee
Зентива А.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива А.С. filed Critical Зентива А.С.
Publication of EA200601393A1 publication Critical patent/EA200601393A1/ru
Publication of EA010131B1 publication Critical patent/EA010131B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Способ получения (R)-(-)-5(2-аминопропил)-2-метоксибенолсульфонамида, имеющего формулу I, и его применение для получения тамсулозина. Защитная группа вводится в N-[(1R)-2(4-метоксифенил)-1-метилэтил]-N-[(1R)-1-фенилэтил)]амин, полученный амид формулы IX подвергается хлорсульфированию и образовавшийся в результате сульфохлорид превращают в сульфонамид формулы X, из которого гидрированием получают соединение формулы I.
EA200601393A 2004-02-05 2005-02-03 Способ получения (r)-(-)-5(2-аминопропил)-2-метоксибензолсульфонамида EA010131B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2004197A CZ2004197A3 (cs) 2004-02-05 2004-02-05 Způsob výroby (R)-(-)-5-(2-aminopropyl)-2-methoxybenzensulfonamidu
PCT/CZ2005/000010 WO2005075415A1 (en) 2004-02-05 2005-02-03 A method of preparation of (r)-(-)-5(2-aminopropyl)-2-methoxybenzenesulfonamide

Publications (2)

Publication Number Publication Date
EA200601393A1 true EA200601393A1 (ru) 2006-12-29
EA010131B1 EA010131B1 (ru) 2008-06-30

Family

ID=34832120

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601393A EA010131B1 (ru) 2004-02-05 2005-02-03 Способ получения (r)-(-)-5(2-аминопропил)-2-метоксибензолсульфонамида

Country Status (12)

Country Link
US (1) US7638649B2 (ru)
EP (1) EP1996544B1 (ru)
AT (1) ATE487693T1 (ru)
CA (1) CA2554851A1 (ru)
CZ (1) CZ2004197A3 (ru)
DE (1) DE602005024728D1 (ru)
EA (1) EA010131B1 (ru)
ES (1) ES2354615T3 (ru)
PL (1) PL1996544T3 (ru)
PT (1) PT1996544E (ru)
UA (1) UA85581C2 (ru)
WO (1) WO2005075415A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT103216B (pt) * 2004-12-06 2010-05-19 Hovione Farmaciencia S A Preparação de tamsulosin
WO2007031823A1 (en) * 2005-09-12 2007-03-22 Aurobindo Pharma Limited An improved process for preparing tamsulosin hydrochloride
US20090221857A1 (en) * 2005-10-28 2009-09-03 Ignasi Auquer Pedemonte Process for the preparation of tamsulosin and related compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62114952A (ja) 1985-11-13 1987-05-26 Yamanouchi Pharmaceut Co Ltd 置換フエネチルアミン誘導体の製造法
JPH066565B2 (ja) 1986-07-21 1994-01-26 山之内製薬株式会社 光学活性なベンゼンスルホンアミド誘導体の製造法
KR100525493B1 (ko) 2001-02-23 2005-11-02 연성정밀화학(주) 설파모일 치환 페네틸아민 유도체의 제조 방법

Also Published As

Publication number Publication date
ATE487693T1 (de) 2010-11-15
CZ295583B6 (cs) 2005-08-17
EP1996544A1 (en) 2008-12-03
UA85581C2 (en) 2009-02-10
PL1996544T3 (pl) 2011-04-29
PT1996544E (pt) 2011-01-19
ES2354615T3 (es) 2011-03-16
EA010131B1 (ru) 2008-06-30
EP1996544B1 (en) 2010-11-10
CZ2004197A3 (cs) 2005-08-17
DE602005024728D1 (de) 2010-12-23
US7638649B2 (en) 2009-12-29
US20080319225A1 (en) 2008-12-25
WO2005075415A1 (en) 2005-08-18
CA2554851A1 (en) 2005-08-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU