TR201818979T4 - Açil sülfonamidlerin polimorfları. - Google Patents

Açil sülfonamidlerin polimorfları. Download PDF

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Publication number
TR201818979T4
TR201818979T4 TR2018/18979T TR201818979T TR201818979T4 TR 201818979 T4 TR201818979 T4 TR 201818979T4 TR 2018/18979 T TR2018/18979 T TR 2018/18979T TR 201818979 T TR201818979 T TR 201818979T TR 201818979 T4 TR201818979 T4 TR 201818979T4
Authority
TR
Turkey
Prior art keywords
polymorphs
acyl sulfonamides
chloro
phenyl
sulfonamides
Prior art date
Application number
TR2018/18979T
Other languages
English (en)
Inventor
Prentice Davidson James
Martin Michael
Pang Fei
Wong Margaret
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TR201818979T4 publication Critical patent/TR201818979T4/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mevcut başvuru, monoterapide veya kombinasyon terapisinde AIDS veya ARC gibi HIV aracılı hastalıkların tedavisi veya profilaksisine yönelik üretimi, işlemeyi ve formüle etmeyi kolaylaştıran gelişmiş stabilite ve fiziksel özelliklere sahip, 2-[4-Bromo-3-(3-kloro-5-siyano-fenoksi)-2-floro-fenil]-N-(2-kloro-4-propionilsülfamoil-fenil)-asetamid, sodyum tuzunun (Ib) yeni polimorfik kristalin formlarını açıklar.
TR2018/18979T 2008-09-09 2009-08-31 Açil sülfonamidlerin polimorfları. TR201818979T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9536408P 2008-09-09 2008-09-09

Publications (1)

Publication Number Publication Date
TR201818979T4 true TR201818979T4 (tr) 2019-01-21

Family

ID=41664548

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/18979T TR201818979T4 (tr) 2008-09-09 2009-08-31 Açil sülfonamidlerin polimorfları.

Country Status (16)

Country Link
US (1) US8063103B2 (tr)
EP (1) EP2334638B1 (tr)
JP (6) JP5989339B2 (tr)
KR (7) KR102437499B1 (tr)
CN (1) CN102143943B (tr)
AU (1) AU2009290988B2 (tr)
BR (3) BR122021020474B1 (tr)
CA (5) CA2735192C (tr)
EA (1) EA019340B1 (tr)
ES (1) ES2706875T3 (tr)
IL (4) IL299322A (tr)
MX (1) MX2011002319A (tr)
PL (1) PL2334638T3 (tr)
TR (1) TR201818979T4 (tr)
UA (1) UA107561C2 (tr)
WO (1) WO2010028968A2 (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2644156C1 (ru) 2017-02-28 2018-02-08 Александр Васильевич Иващенко Пролекарство ингибитора NS5B HCV полимеразы, способ его получения и применения
RU2665383C9 (ru) * 2017-06-22 2019-07-23 Общество с ограниченной ответственностью "Вириом" Фармацевтическая наносуспензия для терапии ВИЧ-инфекции
RU2662160C9 (ru) * 2017-07-03 2018-10-22 Александрович Иващенко Андрей Комбинированный лекарственный препарат для терапии вирусных инфекций
RU2716257C1 (ru) * 2019-04-30 2020-03-11 Андрей Александрович Иващенко Активный компонент, фармацевтическая композиция и лекарственный препарат для терапии ВИЧ и СПИДа
RU2717101C1 (ru) 2019-06-03 2020-03-18 Андрей Александрович Иващенко Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69813539T2 (de) * 1997-01-23 2003-12-18 Yamanouchi Pharma Co Ltd Neue amid-derivate und medizinische zusammensetzungen die diese enthalten
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
DK1742908T3 (da) * 2004-04-23 2010-01-18 Hoffmann La Roche Ikke nukleosid revers transkriptase inhibitorer
US7625949B2 (en) * 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
BRPI0609879A2 (pt) * 2005-04-28 2010-05-11 Pfizer Ltd derivados de aminoácidos
BRPI0617720A2 (pt) * 2005-10-19 2011-08-02 Hoffmann La Roche compostos inibidores de nnrt de fenil-acetamida, usos dos referidos compostos e composição farmacêutica que os contém
CA2693390C (en) * 2007-07-30 2017-01-17 Ardea Biosciences, Inc. Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
EP2262477A1 (en) * 2008-03-04 2010-12-22 F. Hoffmann-La Roche AG Process for preparing concentrated aqueous micellar solutions

Also Published As

Publication number Publication date
CN102143943A (zh) 2011-08-03
KR101678700B1 (ko) 2016-11-22
KR20210108499A (ko) 2021-09-02
MX2011002319A (es) 2011-04-05
US20100063154A1 (en) 2010-03-11
CA2949912A1 (en) 2010-03-18
EA201100451A1 (ru) 2011-10-31
ES2706875T3 (es) 2019-04-01
BRPI0918526A2 (pt) 2015-12-01
CA3003213A1 (en) 2010-03-18
BR122021020474B1 (pt) 2022-06-07
JP2019194229A (ja) 2019-11-07
CA2735192C (en) 2017-02-28
IL211353A0 (en) 2011-05-31
KR101822319B1 (ko) 2018-01-25
CA3059552A1 (en) 2010-03-18
IL244350A0 (en) 2016-05-01
IL264118A (en) 2019-02-28
CA2735192A1 (en) 2010-03-18
AU2009290988B2 (en) 2016-01-28
KR20180110237A (ko) 2018-10-08
EP2334638B1 (en) 2018-11-21
IL211353A (en) 2016-04-21
EP2334638A2 (en) 2011-06-22
PL2334638T3 (pl) 2019-04-30
KR20110053234A (ko) 2011-05-19
US8063103B2 (en) 2011-11-22
EA019340B1 (ru) 2014-02-28
CA3059552C (en) 2021-03-16
KR20220120723A (ko) 2022-08-30
IL299322A (en) 2023-02-01
BRPI0918526B1 (pt) 2022-02-15
CA2949912C (en) 2019-12-03
JP2016172741A (ja) 2016-09-29
KR102437499B1 (ko) 2022-08-29
WO2010028968A2 (en) 2010-03-18
WO2010028968A3 (en) 2010-06-10
KR20230113420A (ko) 2023-07-28
UA107561C2 (xx) 2015-01-26
CA3086566A1 (en) 2010-03-18
CA3003213C (en) 2021-07-20
JP2023082131A (ja) 2023-06-13
BR122021020475B1 (pt) 2022-06-07
CN102143943B (zh) 2014-03-12
JP5989339B2 (ja) 2016-09-07
AU2009290988A1 (en) 2010-03-18
JP6450340B2 (ja) 2019-01-09
KR20180001582A (ko) 2018-01-04
JP2021176894A (ja) 2021-11-11
KR20160092049A (ko) 2016-08-03
JP2012502075A (ja) 2012-01-26
KR102560207B1 (ko) 2023-07-27
JP2018058862A (ja) 2018-04-12

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