EA200501845A2 - НОВЫЕ СОЕДИНЕНИЯ ЦИННАМАТА БЕНЗО[b]ПИРАНО[3,2-h]АКРИДИН-7-ОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, КОТОРЫЕ ИХ СОДЕРЖАТ - Google Patents

НОВЫЕ СОЕДИНЕНИЯ ЦИННАМАТА БЕНЗО[b]ПИРАНО[3,2-h]АКРИДИН-7-ОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, КОТОРЫЕ ИХ СОДЕРЖАТ

Info

Publication number
EA200501845A2
EA200501845A2 EA200501845A EA200501845A EA200501845A2 EA 200501845 A2 EA200501845 A2 EA 200501845A2 EA 200501845 A EA200501845 A EA 200501845A EA 200501845 A EA200501845 A EA 200501845A EA 200501845 A2 EA200501845 A2 EA 200501845A2
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
aryl
optionally substituted
halo
acridin
Prior art date
Application number
EA200501845A
Other languages
English (en)
Other versions
EA010094B1 (ru
EA200501845A3 (ru
Inventor
Мишель Кош
Франсуа Тийекен
Сильви Мишель
Джон Хикман
Ален Пьер
Стефан Леонс
Брюно Пфайффер
Лоранс Краус-Бертье
Original Assignee
Ле Лаборатур Сервье
Сентр Насьональ Де Ла-Решерн Сьянтифик (Снрс)
Юниверсите Рене Декарт Парис V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатур Сервье, Сентр Насьональ Де Ла-Решерн Сьянтифик (Снрс), Юниверсите Рене Декарт Парис V filed Critical Ле Лаборатур Сервье
Publication of EA200501845A2 publication Critical patent/EA200501845A2/ru
Publication of EA200501845A3 publication Critical patent/EA200501845A3/ru
Publication of EA010094B1 publication Critical patent/EA010094B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Соединения формулы (I)в которой X и Y каждый представляют собой группу, выбранную из водорода, галогена, алкокси, нитро, циано, алкила, алкенила, полигалоалкила и -NRR, где Rи Rимеют значения, указанные в описании,Z представляет собой атом кислорода или NR, где Rимеет значения, указанные в описании,Ar представляет собой арил или гетероарил,Rпредставляет собой атом водорода или алкильную группу,Rпредставляет собой группу, выбранную из атома водорода, алкила, -ORи -NRR, где Rи Rимеют значения, указанные в описании,Rи Rпредставляют собой атом водорода или алкильную группу,Rпредставляет собой атом водорода или группу формулы OR, NRR, W-C(W)-U-V, W-C(W)-W-Tили Z-CO-CH=CHAr, где R, R, W, W, W, U, V, T, Z и Ar имеют значения, указанные в описании,их энантиомеры, а также их соли присоединения с фармацевтически приемлемой кислотой или основанием. Лекарственные средства.
EA200501845A 2004-12-22 2005-12-21 НОВЫЕ СОЕДИНЕНИЯ ЦИННАМАТА БЕНЗО[b]ПИРАНО[3,2-h]АКРИДИН-7-ОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, КОТОРЫЕ ИХ СОДЕРЖАТ EA010094B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0413682A FR2879600B1 (fr) 2004-12-22 2004-12-22 Nouveaux derives cinnamates de benzo[b]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200501845A2 true EA200501845A2 (ru) 2006-06-30
EA200501845A3 EA200501845A3 (ru) 2006-10-27
EA010094B1 EA010094B1 (ru) 2008-06-30

Family

ID=34954114

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501845A EA010094B1 (ru) 2004-12-22 2005-12-21 НОВЫЕ СОЕДИНЕНИЯ ЦИННАМАТА БЕНЗО[b]ПИРАНО[3,2-h]АКРИДИН-7-ОНА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, КОТОРЫЕ ИХ СОДЕРЖАТ

Country Status (26)

Country Link
US (1) US7144891B2 (ru)
EP (1) EP1674101B1 (ru)
JP (1) JP2006176525A (ru)
KR (1) KR100742060B1 (ru)
CN (1) CN1796387A (ru)
AT (1) ATE378050T1 (ru)
AU (1) AU2005247032A1 (ru)
BR (1) BRPI0506019A (ru)
CA (1) CA2529630A1 (ru)
CY (1) CY1107100T1 (ru)
DE (1) DE602005003315T2 (ru)
DK (1) DK1674101T3 (ru)
EA (1) EA010094B1 (ru)
ES (1) ES2297648T3 (ru)
FR (1) FR2879600B1 (ru)
HR (1) HRP20070524T3 (ru)
MA (1) MA27965A1 (ru)
MX (1) MXPA05013993A (ru)
MY (1) MY138045A (ru)
NO (1) NO20056091L (ru)
NZ (1) NZ544315A (ru)
PL (1) PL1674101T3 (ru)
PT (1) PT1674101E (ru)
SG (1) SG123675A1 (ru)
SI (1) SI1674101T1 (ru)
ZA (1) ZA200510323B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2902792A1 (fr) * 2006-06-21 2007-12-28 Servier Lab Nouveaux derives cinnamates de tetrahydro-7h-pyrano(2,3-c)acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772765B1 (fr) * 1997-12-19 2000-03-17 Adir Nouveaux derives de l'acronycine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2795071B1 (fr) * 1999-06-16 2001-07-27 Adir Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7056929B2 (en) * 2001-07-25 2006-06-06 Les Laboratoires Servier Benzo[b]pyrano[3,2-h]acridin-7-one compounds
FR2827864B1 (fr) * 2001-07-25 2005-09-16 Servier Lab Nouveaux derives de benzo[b]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
KR20060072093A (ko) 2006-06-27
SG123675A1 (en) 2006-07-26
DE602005003315T2 (de) 2008-09-25
US20060135545A1 (en) 2006-06-22
ES2297648T3 (es) 2008-05-01
HRP20070524T3 (en) 2008-07-31
EA010094B1 (ru) 2008-06-30
CN1796387A (zh) 2006-07-05
ZA200510323B (en) 2006-12-27
JP2006176525A (ja) 2006-07-06
DE602005003315D1 (de) 2007-12-27
MY138045A (en) 2009-04-30
US7144891B2 (en) 2006-12-05
NO20056091L (no) 2006-06-23
BRPI0506019A (pt) 2006-09-19
KR100742060B1 (ko) 2007-07-23
ATE378050T1 (de) 2007-11-15
FR2879600B1 (fr) 2007-02-09
EA200501845A3 (ru) 2006-10-27
EP1674101A1 (fr) 2006-06-28
PL1674101T3 (pl) 2008-05-30
PT1674101E (pt) 2007-12-17
MXPA05013993A (es) 2006-06-21
SI1674101T1 (sl) 2008-04-30
NZ544315A (en) 2006-11-30
FR2879600A1 (fr) 2006-06-23
MA27965A1 (fr) 2006-07-03
EP1674101B1 (fr) 2007-11-14
AU2005247032A1 (en) 2006-07-06
CY1107100T1 (el) 2012-10-24
DK1674101T3 (da) 2008-03-03
CA2529630A1 (fr) 2006-06-22

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