EA200500871A1 - Пептиды, ингибирующие ангиогенез, миграцию клеток, инвазию клеток и пролиферацию клеток, композиции и их применение - Google Patents

Пептиды, ингибирующие ангиогенез, миграцию клеток, инвазию клеток и пролиферацию клеток, композиции и их применение

Info

Publication number
EA200500871A1
EA200500871A1 EA200500871A EA200500871A EA200500871A1 EA 200500871 A1 EA200500871 A1 EA 200500871A1 EA 200500871 A EA200500871 A EA 200500871A EA 200500871 A EA200500871 A EA 200500871A EA 200500871 A1 EA200500871 A1 EA 200500871A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cell
peptides
compositions
invasiation
application
Prior art date
Application number
EA200500871A
Other languages
English (en)
Russian (ru)
Inventor
Эйми Л. Аллан
Фернандо Доунейт
Стефани А. Хопкинс
Патриция Л. Глэдстоун
Эндрю Мазар
Шон М. О` Харе
Грэхам Пэрри
Мэриан Л. Планкетт
Роберт Дж. Тернански
Вон Хунг Йон
Original Assignee
Атеньюон, Ллк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Атеньюон, Ллк filed Critical Атеньюон, Ллк
Publication of EA200500871A1 publication Critical patent/EA200500871A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
EA200500871A 2002-11-25 2003-11-25 Пептиды, ингибирующие ангиогенез, миграцию клеток, инвазию клеток и пролиферацию клеток, композиции и их применение EA200500871A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42917402P 2002-11-25 2002-11-25
US47553903P 2003-06-02 2003-06-02
PCT/US2003/038175 WO2004047771A2 (en) 2002-11-25 2003-11-25 Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof

Publications (1)

Publication Number Publication Date
EA200500871A1 true EA200500871A1 (ru) 2006-04-28

Family

ID=32397181

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200500871A EA200500871A1 (ru) 2002-11-25 2003-11-25 Пептиды, ингибирующие ангиогенез, миграцию клеток, инвазию клеток и пролиферацию клеток, композиции и их применение
EA200500870A EA200500870A1 (ru) 2002-11-25 2003-11-25 Пептиды, которые нацелены на опухоль и эндотелиальные клетки, композиции и их применения

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200500870A EA200500870A1 (ru) 2002-11-25 2003-11-25 Пептиды, которые нацелены на опухоль и эндотелиальные клетки, композиции и их применения

Country Status (14)

Country Link
US (2) US7517855B2 (https=)
EP (2) EP1594521A4 (https=)
JP (2) JP2006515866A (https=)
KR (2) KR20050097494A (https=)
AU (2) AU2003297609A1 (https=)
BR (2) BR0316523A (https=)
CA (2) CA2507045A1 (https=)
EA (2) EA200500871A1 (https=)
HR (2) HRP20050585A2 (https=)
MX (2) MXPA05005545A (https=)
NO (2) NO20053112L (https=)
NZ (2) NZ540889A (https=)
PL (2) PL377763A1 (https=)
WO (2) WO2004047771A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20050585A2 (en) * 2002-11-25 2006-02-28 Attenuon Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
JP2007538233A (ja) * 2004-05-21 2007-12-27 エムディーエス インコーポレイテッド ドゥーイング ビジネス スルー イッツ エムディーエス ファーマ サービシーズ ディビジョン 医療デバイスの細胞結合特性を定量する方法
US20060078535A1 (en) * 2004-10-13 2006-04-13 The Regents Of The University Of Michigan Anticancer compounds and methods
EP1846437A1 (en) 2005-02-01 2007-10-24 Attenuon, LLC ACID ADDITION SALTS OF Ac-PHSCN-NH2
JP2008528630A (ja) * 2005-02-01 2008-07-31 アテニュオン，エルエルシー 抗血管新生ｐｈｓｃｎペプチドを含む組成物
AU2016213759B2 (en) * 2006-11-08 2018-03-29 Chongxi Yu Transdermal delivery systems of peptides and related compounds
WO2008056207A1 (en) * 2006-11-08 2008-05-15 Chongxi Yu Transdermal delivery systems of peptides and related compounds
EP2427475B1 (en) 2009-05-08 2020-11-04 Techfields Biochem Co., Ltd. High penetration prodrug compositions of peptides and peptide-related compounds
KR101228668B1 (ko) 2010-09-17 2013-01-31 가톨릭대학교 산학협력단 혈관신생 억제 활성을 갖는 펩타이드 및 이의 용도
GB2510488B (en) 2011-06-23 2020-04-08 Univ Texas Identifying peptides at the single molecule level
WO2016069124A1 (en) * 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
CN102417540A (zh) * 2011-11-21 2012-04-18 中国药科大学 一种聚乙二醇修饰的整合素阻断剂hm-3及其应用
JP6206987B2 (ja) * 2012-05-11 2017-10-04 メディカス バイオサイエンシーズ，エルエルシー 網膜剥離の処置のための生体適合性ヒドロゲル製剤
WO2013181738A1 (en) 2012-06-04 2013-12-12 Suncor Energy Inc. Formulations containing paraffinic oil and anti-settling agent
EP2967056B1 (en) 2013-03-15 2018-02-21 Suncor Energy Inc. Herbicidal compositions
JP5970439B2 (ja) * 2013-09-20 2016-08-17 チョンシー ユー ペプチド及び関連化合物の経皮送達システム
AU2019301750A1 (en) 2018-07-12 2021-01-28 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
GB2593091B (en) 2018-10-05 2023-12-20 Univ Texas Solid-phase N-terminal peptide capture and release
BR112021014592A2 (pt) 2019-01-25 2021-10-05 Suncor Energy Inc. Compostos fotosensibilizadores, métodos de fabricação e aplicação em plantas
AU2020222515B2 (en) 2019-02-15 2025-10-09 Nutrien Ag Solutions (Canada) Inc. The use of protoporphyrin IX derivatives to improve the health of plants

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4440788A (en) * 1980-05-13 1984-04-03 Mitsubishi Chemical Industries, Limited Cysteine derivatives
WO1981003330A1 (fr) 1980-05-13 1981-11-26 Mitsubishi Chem Ind Derives de la cysteine et leur production
US4394519A (en) * 1982-01-19 1983-07-19 Research Corporation Amino acid blocking agents
GB8504253D0 (en) * 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5091176A (en) * 1988-11-02 1992-02-25 W. R. Grace & Co.-Conn. Polymer-modified peptide drugs having enhanced biological and pharmacological activities
US5443816A (en) 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5229366A (en) * 1990-10-23 1993-07-20 Fuji Photo Film Co., Ltd. Peptide-containing polyethylene glycol derivatives and application thereof
US5149801A (en) * 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5556609A (en) 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5639725A (en) * 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
DE69605025T2 (de) 1995-03-14 2000-07-20 Siemens Ag Ultraschallzerstäuber mit abnehmbarer präzisionsdosiereinheit
US5970974A (en) * 1995-03-14 1999-10-26 Siemens Aktiengesellschaft Dosating unit for an ultrasonic atomizer device
US5618513A (en) * 1995-06-07 1997-04-08 Mallinckrodt Medical, Inc. Method for preparing radiolabeled peptides
MY147327A (en) * 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
EP0927045B1 (en) * 1996-09-10 2005-12-14 The Burnham Institute Tumor homing molecules, conjugates derived therefrom, and methods of using same
US6025150A (en) * 1996-11-21 2000-02-15 The Regents Of The University Of Michigan Methods and compositions for wound healing
US6001965A (en) * 1996-11-21 1999-12-14 The Regents Of The University Of Michigan Anticancer compounds and methods
US6331409B1 (en) * 1996-11-21 2001-12-18 The Regents Of The University Of Michigan Methods and compositions for wound healing
WO1998030538A1 (en) * 1997-01-14 1998-07-16 Kaneka Corporation Process for producing cysteine derivatives
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
WO1999013329A1 (en) * 1997-09-10 1999-03-18 The Burnham Institute Methods of identifying molecules that home to angiogenic vasculature in tumors
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
AU5671099A (en) * 1998-08-14 2000-03-06 The Administrators Of The Tulane Eductional Fund Compounds having growth hormone releasing activity
CA2435320C (en) 2001-01-18 2008-06-03 The Regents Of The University Of Michigan Compositions and methods for the use of fibronectin fragments in the diagnosis of cancer
HRP20050585A2 (en) * 2002-11-25 2006-02-28 Attenuon Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof

Also Published As

Publication number Publication date
JP2006514116A (ja) 2006-04-27
NO20053112L (no) 2005-08-05
WO2004063213A2 (en) 2004-07-29
NO20053111D0 (no) 2005-06-24
NZ540363A (en) 2007-11-30
BR0316523A (pt) 2005-10-18
NO20053111L (no) 2005-08-24
NO20053112D0 (no) 2005-06-24
CA2506813A1 (en) 2004-07-29
US20040162239A1 (en) 2004-08-19
PL377763A1 (pl) 2006-02-20
EP1594521A2 (en) 2005-11-16
WO2004047771A2 (en) 2004-06-10
EP1569678A2 (en) 2005-09-07
US20050020810A1 (en) 2005-01-27
BR0316550A (pt) 2005-10-04
US7517855B2 (en) 2009-04-14
AU2003298726A1 (en) 2004-08-10
NZ540889A (en) 2008-09-26
HRP20050584A2 (hr) 2006-04-30
JP2006515866A (ja) 2006-06-08
KR20050097494A (ko) 2005-10-07
WO2004047771A3 (en) 2005-09-15
EA200500870A1 (ru) 2006-04-28
CA2507045A1 (en) 2004-06-10
MXPA05005545A (es) 2005-10-18
EP1594521A4 (en) 2008-01-09
EP1569678A4 (en) 2008-01-02
KR20050096917A (ko) 2005-10-06
WO2004063213A3 (en) 2005-03-03
HRP20050585A2 (en) 2006-02-28
PL377701A1 (pl) 2006-02-06
MXPA05005469A (es) 2005-09-08
AU2003297609A1 (en) 2004-06-18

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