EA200500659A1 - Способ получения кардиолипина или его аналога (варианты) и содержащей их липосомы, способы использования кардиолипина или его аналогов в лечении болезней (варианты) и содержащая их композиция (варианты) и ее применение - Google Patents
Способ получения кардиолипина или его аналога (варианты) и содержащей их липосомы, способы использования кардиолипина или его аналогов в лечении болезней (варианты) и содержащая их композиция (варианты) и ее применениеInfo
- Publication number
- EA200500659A1 EA200500659A1 EA200500659A EA200500659A EA200500659A1 EA 200500659 A1 EA200500659 A1 EA 200500659A1 EA 200500659 A EA200500659 A EA 200500659A EA 200500659 A EA200500659 A EA 200500659A EA 200500659 A1 EA200500659 A1 EA 200500659A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cardiolipin
- liposomes
- methods
- chain
- protected
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 abstract 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41927702P | 2002-10-16 | 2002-10-16 | |
| US42928502P | 2002-11-26 | 2002-11-26 | |
| US43865903P | 2003-01-07 | 2003-01-07 | |
| US46733103P | 2003-05-02 | 2003-05-02 | |
| PCT/US2003/013917 WO2004062569A2 (fr) | 2003-01-07 | 2003-05-04 | Compositions de cardiolipine, leurs procedes de preparation et d'utilisation |
| PCT/US2003/016412 WO2003099830A2 (fr) | 2002-05-24 | 2003-05-23 | Compositions de cardiolipine, leurs procedes de preparation et d'utilisation |
| PCT/US2003/027806 WO2004039817A1 (fr) | 2002-10-16 | 2003-09-05 | Molecules de cardiolipine et procedes pour leur synthese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200500659A1 true EA200500659A1 (ru) | 2005-10-27 |
Family
ID=32234368
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200500659A EA200500659A1 (ru) | 2002-10-16 | 2003-09-05 | Способ получения кардиолипина или его аналога (варианты) и содержащей их липосомы, способы использования кардиолипина или его аналогов в лечении болезней (варианты) и содержащая их композиция (варианты) и ее применение |
| EA200500661A EA200500661A1 (ru) | 2002-10-16 | 2003-10-16 | Катионный аналог кардиолипина (варианты), его применение (варианты), композиция и набор для трансфекции клеток (варианты) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200500661A EA200500661A1 (ru) | 2002-10-16 | 2003-10-16 | Катионный аналог кардиолипина (варианты), его применение (варианты), композиция и набор для трансфекции клеток (варианты) |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP1556392A1 (fr) |
| JP (2) | JP2006510733A (fr) |
| AU (2) | AU2003268478A1 (fr) |
| CA (2) | CA2502285A1 (fr) |
| EA (2) | EA200500659A1 (fr) |
| HK (1) | HK1080087A1 (fr) |
| WO (2) | WO2004039817A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| WO2006004935A2 (fr) * | 2004-06-29 | 2006-01-12 | Neopharm, Inc. | Analogues de cardiolipines pegylees, methodes de synthese et utilisations associees |
| MX2007005591A (es) * | 2004-11-08 | 2008-02-12 | Neopharm Inc | Sintesis de analogos de cardiolipina y usos de los mismos. |
| EP1874793A4 (fr) | 2005-04-15 | 2008-12-24 | Univ Texas | Administration d'arnsi par compositions lipidiques neutres |
| WO2007014150A2 (fr) * | 2005-07-22 | 2007-02-01 | Neopharm, Inc. | Procede d'administration de liposomes contenant des oligonucleotides |
| WO2007065017A2 (fr) * | 2005-12-01 | 2007-06-07 | Pronai Therapeutics, Inc. | Systeme d'administration de liposomes cationiques a oligonucleotides |
| EP1957044B1 (fr) | 2005-12-01 | 2013-03-13 | Pronai Therapeutics, Inc. | Formulation de liposomes amphoteres |
| BRPI0708187A2 (pt) * | 2006-02-24 | 2011-05-24 | Neopharm Inc | método e processo para preparar cardiolipina |
| MX2011003207A (es) * | 2008-09-27 | 2011-11-04 | Jina Pharmaceuticals Inc | Preparaciones farmaceuticas a base de lipidos para la aplicacion oral y topica; sus composiciones, metodos y usos. |
| JP6014241B2 (ja) * | 2012-04-11 | 2016-10-25 | リポクセン テクノロジーズ リミテッド | ミエリン塩基性タンパク質のオリゴペプチドフラグメントを含有するリポソーム、医薬組成物および多発性硬化症の治療方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2113606A (en) * | 1934-05-24 | 1938-04-12 | Alba Pharmaceutical Company In | Quaternary ammonium compounds |
| US6461637B1 (en) * | 2000-09-01 | 2002-10-08 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
| EP1829856A3 (fr) * | 1998-11-12 | 2009-02-25 | Invitrogen Corporation | Réactifs de transfection |
| DE60016205T2 (de) * | 1999-05-28 | 2005-12-01 | Vical, Inc., San Diego | Cytofectin-dimere und verfahren zu ihrer anwendung |
-
2003
- 2003-09-05 EA EA200500659A patent/EA200500659A1/ru unknown
- 2003-09-05 EP EP03749443A patent/EP1556392A1/fr not_active Withdrawn
- 2003-09-05 JP JP2005501873A patent/JP2006510733A/ja active Pending
- 2003-09-05 CA CA002502285A patent/CA2502285A1/fr not_active Abandoned
- 2003-09-05 WO PCT/US2003/027806 patent/WO2004039817A1/fr not_active Application Discontinuation
- 2003-09-05 AU AU2003268478A patent/AU2003268478A1/en not_active Abandoned
- 2003-10-16 WO PCT/US2003/033099 patent/WO2004035523A1/fr not_active Application Discontinuation
- 2003-10-16 AU AU2003277445A patent/AU2003277445A1/en not_active Abandoned
- 2003-10-16 CA CA002501990A patent/CA2501990A1/fr not_active Abandoned
- 2003-10-16 JP JP2005501473A patent/JP2006503112A/ja active Pending
- 2003-10-16 EP EP03809159A patent/EP1558562A1/fr not_active Withdrawn
- 2003-10-16 EA EA200500661A patent/EA200500661A1/ru unknown
-
2005
- 2005-12-30 HK HK05112200.6A patent/HK1080087A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200500661A1 (ru) | 2005-10-27 |
| AU2003277445A1 (en) | 2004-05-04 |
| EP1558562A1 (fr) | 2005-08-03 |
| WO2004039817A1 (fr) | 2004-05-13 |
| WO2004039817A9 (fr) | 2004-07-22 |
| JP2006510733A (ja) | 2006-03-30 |
| CA2502285A1 (fr) | 2004-05-13 |
| CA2501990A1 (fr) | 2004-04-29 |
| AU2003268478A1 (en) | 2004-05-25 |
| WO2004035523B1 (fr) | 2004-08-26 |
| EP1556392A1 (fr) | 2005-07-27 |
| JP2006503112A (ja) | 2006-01-26 |
| HK1080087A1 (zh) | 2006-04-21 |
| WO2004035523A1 (fr) | 2004-04-29 |
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