HK1080087A1 - 心磷脂分子和其合成方法 - Google Patents
心磷脂分子和其合成方法Info
- Publication number
- HK1080087A1 HK1080087A1 HK05112200.6A HK05112200A HK1080087A1 HK 1080087 A1 HK1080087 A1 HK 1080087A1 HK 05112200 A HK05112200 A HK 05112200A HK 1080087 A1 HK1080087 A1 HK 1080087A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- synthesis
- cardiolipin molecules
- cardiolipin
- molecules
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41927702P | 2002-10-16 | 2002-10-16 | |
US42928502P | 2002-11-26 | 2002-11-26 | |
US43865903P | 2003-01-07 | 2003-01-07 | |
US46733103P | 2003-05-02 | 2003-05-02 | |
PCT/US2003/013917 WO2004062569A2 (fr) | 2003-01-07 | 2003-05-04 | Compositions de cardiolipine, leurs procedes de preparation et d'utilisation |
PCT/US2003/016412 WO2003099830A2 (fr) | 2002-05-24 | 2003-05-23 | Compositions de cardiolipine, leurs procedes de preparation et d'utilisation |
PCT/US2003/027806 WO2004039817A1 (fr) | 2002-10-16 | 2003-09-05 | Molecules de cardiolipine et procedes pour leur synthese |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1080087A1 true HK1080087A1 (zh) | 2006-04-21 |
Family
ID=32234368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05112200.6A HK1080087A1 (zh) | 2002-10-16 | 2005-12-30 | 心磷脂分子和其合成方法 |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP1556392A1 (fr) |
JP (2) | JP2006510733A (fr) |
AU (2) | AU2003268478A1 (fr) |
CA (2) | CA2502285A1 (fr) |
EA (2) | EA200500659A1 (fr) |
HK (1) | HK1080087A1 (fr) |
WO (2) | WO2004039817A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
US20080286351A1 (en) * | 2004-06-29 | 2008-11-20 | Ahmad Moghis U | Pegylated Cardiolipin Analogs, Methods of Synthesis, and Uses Thereof |
WO2006052906A2 (fr) * | 2004-11-08 | 2006-05-18 | Neopharm, Inc. | Synthese de produits analogues de la cardiolipine et leurs applications |
WO2006113679A2 (fr) | 2005-04-15 | 2006-10-26 | Board Of Regents, The University Of Texas System | Administration d'arnsi par compositions lipidiques neutres |
WO2007014150A2 (fr) * | 2005-07-22 | 2007-02-01 | Neopharm, Inc. | Procede d'administration de liposomes contenant des oligonucleotides |
WO2007065017A2 (fr) * | 2005-12-01 | 2007-06-07 | Pronai Therapeutics, Inc. | Systeme d'administration de liposomes cationiques a oligonucleotides |
ES2419106T3 (es) | 2005-12-01 | 2013-08-19 | Pronai Therapeutics, Inc. | Formulación de liposomas anfóteros |
MX2008010826A (es) * | 2006-02-24 | 2009-03-02 | Neopharm Inc | Metodo y proceso para preparar cardiolipina. |
MX2011003207A (es) * | 2008-09-27 | 2011-11-04 | Jina Pharmaceuticals Inc | Preparaciones farmaceuticas a base de lipidos para la aplicacion oral y topica; sus composiciones, metodos y usos. |
AU2013246870B2 (en) * | 2012-04-11 | 2016-06-23 | Lipoxen Technologies Limited | Liposomes containing oligopeptide fragments of myelin basic protein, a pharmaceutical composition and a method for treatment of multiple sclerosis |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2113606A (en) * | 1934-05-24 | 1938-04-12 | Alba Pharmaceutical Company In | Quaternary ammonium compounds |
US6461637B1 (en) * | 2000-09-01 | 2002-10-08 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
ATE383331T1 (de) * | 1998-11-12 | 2008-01-15 | Invitrogen Corp | Transportreagentien |
DE60016205T2 (de) * | 1999-05-28 | 2005-12-01 | Vical, Inc., San Diego | Cytofectin-dimere und verfahren zu ihrer anwendung |
-
2003
- 2003-09-05 CA CA002502285A patent/CA2502285A1/fr not_active Abandoned
- 2003-09-05 EP EP03749443A patent/EP1556392A1/fr not_active Withdrawn
- 2003-09-05 JP JP2005501873A patent/JP2006510733A/ja active Pending
- 2003-09-05 AU AU2003268478A patent/AU2003268478A1/en not_active Abandoned
- 2003-09-05 WO PCT/US2003/027806 patent/WO2004039817A1/fr not_active Application Discontinuation
- 2003-09-05 EA EA200500659A patent/EA200500659A1/ru unknown
- 2003-10-16 AU AU2003277445A patent/AU2003277445A1/en not_active Abandoned
- 2003-10-16 JP JP2005501473A patent/JP2006503112A/ja active Pending
- 2003-10-16 CA CA002501990A patent/CA2501990A1/fr not_active Abandoned
- 2003-10-16 WO PCT/US2003/033099 patent/WO2004035523A1/fr not_active Application Discontinuation
- 2003-10-16 EP EP03809159A patent/EP1558562A1/fr not_active Withdrawn
- 2003-10-16 EA EA200500661A patent/EA200500661A1/ru unknown
-
2005
- 2005-12-30 HK HK05112200.6A patent/HK1080087A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1556392A1 (fr) | 2005-07-27 |
EA200500661A1 (ru) | 2005-10-27 |
CA2502285A1 (fr) | 2004-05-13 |
WO2004039817A1 (fr) | 2004-05-13 |
AU2003268478A1 (en) | 2004-05-25 |
WO2004039817A9 (fr) | 2004-07-22 |
EA200500659A1 (ru) | 2005-10-27 |
JP2006503112A (ja) | 2006-01-26 |
AU2003277445A1 (en) | 2004-05-04 |
WO2004035523A1 (fr) | 2004-04-29 |
EP1558562A1 (fr) | 2005-08-03 |
CA2501990A1 (fr) | 2004-04-29 |
JP2006510733A (ja) | 2006-03-30 |
WO2004035523B1 (fr) | 2004-08-26 |
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