ES2079350T3 - Procedimiento para la determinacion de la actividad de serina-proteasas o de inhibidores de serina-proteasas. - Google Patents

Procedimiento para la determinacion de la actividad de serina-proteasas o de inhibidores de serina-proteasas.

Info

Publication number
ES2079350T3
ES2079350T3 ES88110523T ES88110523T ES2079350T3 ES 2079350 T3 ES2079350 T3 ES 2079350T3 ES 88110523 T ES88110523 T ES 88110523T ES 88110523 T ES88110523 T ES 88110523T ES 2079350 T3 ES2079350 T3 ES 2079350T3
Authority
ES
Spain
Prior art keywords
serine
serin
proteases
activity
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88110523T
Other languages
English (en)
Inventor
Thomas Dr Stief
Norbert Prof Dr Heimburger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2079350T3 publication Critical patent/ES2079350T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8132—Plasminogen activator inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA DETERMINAR LA ACTIVIDAD DE PROTEASAS DE SERINA E INHIBIDORES DE PROTEASA DE SERINA EN PLASMA U OTROS LIQUIDOS BIOLOGICOS. PARA LA DTERMINACION RAPIDA Y EXACTA DEL CONTENIDO DE PROTEASAS DE SERINA O INHIBIDORES DE PROTEASA DE SERINA SE PROPONE EN LA INVENCION UN METODO EN EL QUE INHIBIDORES ESPECIFICOS SON INACTIVADOS POR ADICION DE AL MENOS UN AGENTE OXIDANTE Y SI ES NECESARIO AL MENOS UN DETERGENTE. LA ADICION DE ACIDO OMEGA AMINOCARBOXILICO REFUERZA LOS EFECTOS OBSERVADOS.
ES88110523T 1987-07-03 1988-07-01 Procedimiento para la determinacion de la actividad de serina-proteasas o de inhibidores de serina-proteasas. Expired - Lifetime ES2079350T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873722082 DE3722082A1 (de) 1987-07-03 1987-07-03 Verfahren zur bestimmung der aktivitaet von serinproteasen oder serinproteaseinhibitoren

Publications (1)

Publication Number Publication Date
ES2079350T3 true ES2079350T3 (es) 1996-01-16

Family

ID=6330890

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88110523T Expired - Lifetime ES2079350T3 (es) 1987-07-03 1988-07-01 Procedimiento para la determinacion de la actividad de serina-proteasas o de inhibidores de serina-proteasas.

Country Status (9)

Country Link
US (1) US5057414A (es)
EP (1) EP0297597B1 (es)
JP (1) JP2676792B2 (es)
AT (1) ATE129525T1 (es)
AU (1) AU613053B2 (es)
CA (1) CA1338681C (es)
DE (2) DE3722082A1 (es)
ES (1) ES2079350T3 (es)
MX (1) MX169931B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3705744A1 (de) * 1987-02-23 1988-09-01 Behringwerke Ag Verfahren zur funktionellen bestimmung von protein c-inhibitor
US5248596A (en) * 1987-02-25 1993-09-28 Miles Inc. Method of detecting proteolytically modified antithrombin
DE3819923A1 (de) * 1988-06-11 1989-12-21 Behringwerke Ag Fibrin(ogen)derivate, verfahren zu ihrer herstellung und ihre verwendung
DE3838529A1 (de) * 1988-11-14 1990-05-17 Behringwerke Ag Globaltest zur erfassung der hauptkomponenten des fibrinolysesystems
DE3843422A1 (de) * 1988-12-23 1990-06-28 Behringwerke Ag Verfahren zur bestimmung der plasminogenaktivator-aktivitaet in alpha-2-antiplasmin-haltigen proben
DE3929329A1 (de) * 1989-09-04 1991-03-07 Behringwerke Ag Stabilisierungsmittel zur verbesserung der wiederfindung von gerinnungsfaktoren in blutproben
DE4016978A1 (de) * 1990-05-25 1991-11-28 Behringwerke Ag Verfahren zum nachweis von plasminogen-aktivatoren, deren inhibitoren oder stimulatoren
WO1995012371A1 (en) * 1993-11-03 1995-05-11 Clarion Pharmaceuticals, Inc. Hemostatic patch
US5639726A (en) * 1994-09-30 1997-06-17 The Regents Of The University Of Michigan Peptide mediated enhancement of thrombolysis methods and compositions
US6403092B1 (en) 1998-04-01 2002-06-11 Duke University Immune response modulator alpha-2 macroglobulin complex
WO2001016324A2 (en) * 1999-08-31 2001-03-08 Board Of Regents, The University Of Texas System Methods and compositions of a novel serine protease inhibitor
DE10116586B4 (de) * 2001-04-03 2005-07-21 Stief, Thomas, Dr.med. Testsystem zur Bestimmung der Hämostaseaktivierung von biologischen Flüssigkeiten
JP3990972B2 (ja) * 2001-11-20 2007-10-17 有限会社 キック 血管再狭窄防止薬及び該防止薬がコーティングされた血管内埋め込み器具
EP1745292A2 (en) 2004-04-28 2007-01-24 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 1 (dpp1)
DE102004025780B4 (de) 2004-05-26 2008-04-03 Stief, Thomas, Dr.med. Verfahren zur Anti-Limulus-Faktoren-unabhängigen Bestimmung der Lipopolysaccharid- und/oder Lipid-A- und/oder Glukan-Reaktivität, dafür geeignetes Testsystem sowie dessen Verwendung
EP2484775A1 (de) * 2011-02-07 2012-08-08 Siemens Healthcare Diagnostics Products GmbH Heparin-insensitives Verfahren zur Bestimmung von direkten Gerinnungsfaktorinhibitoren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493891A (en) * 1982-07-27 1985-01-15 University Of Georgia Research Foundation, Inc. Determination of oxidized α-1-proteinase inhibitor in serum or plasma
DE3512909A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Verfahren zur bestimmung von plasminogenaktivatoren (pa)
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US5102787A (en) * 1987-07-10 1992-04-07 Miho Sasamata Method, device and kit for measurement of tissue plasminogen activator activity

Also Published As

Publication number Publication date
EP0297597B1 (de) 1995-10-25
DE3722082A1 (de) 1989-01-12
AU613053B2 (en) 1991-07-25
DE3854611D1 (de) 1995-11-30
US5057414A (en) 1991-10-15
EP0297597A2 (de) 1989-01-04
ATE129525T1 (de) 1995-11-15
AU1861588A (en) 1989-01-05
JPS6430599A (en) 1989-02-01
CA1338681C (en) 1996-10-29
JP2676792B2 (ja) 1997-11-17
MX169931B (es) 1993-08-02
EP0297597A3 (en) 1990-10-03

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