EA200500081A1 - Акутумин и соединения акутумина, синтез и применение - Google Patents
Акутумин и соединения акутумина, синтез и применениеInfo
- Publication number
- EA200500081A1 EA200500081A1 EA200500081A EA200500081A EA200500081A1 EA 200500081 A1 EA200500081 A1 EA 200500081A1 EA 200500081 A EA200500081 A EA 200500081A EA 200500081 A EA200500081 A EA 200500081A EA 200500081 A1 EA200500081 A1 EA 200500081A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrogen atom
- compounds
- acutumin
- synthesis
- application
- Prior art date
Links
- PXTPGGRVOOOTDS-UHFFFAOYSA-N Acutumin Natural products C1C(OC)=CC(=O)C21C1(CC(=O)C(OC)=C3OC)CCN(C)C13CC2Cl PXTPGGRVOOOTDS-UHFFFAOYSA-N 0.000 title 1
- FSXRARBVZZKCGJ-FMAJMWNWSA-N Acutumine Chemical class O[C@@H]1C(OC)=CC(=O)[C@@]11[C@@]2(CC(=O)C(OC)=C3OC)CCN(C)[C@@]23C[C@@H]1Cl FSXRARBVZZKCGJ-FMAJMWNWSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- FSXRARBVZZKCGJ-UHFFFAOYSA-N dauricumine Natural products OC1C(OC)=CC(=O)C11C2(CC(=O)C(OC)=C3OC)CCN(C)C23CC1Cl FSXRARBVZZKCGJ-UHFFFAOYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Abstract
Изобретение относится к акутумину и его соединениям, а также к соединениям формулы (I)в которых Rи Rкаждый представляет собой атом водорода или вместе образуют дополнительную связь, Rпредставляет собой атом водорода или алкоксигруппу, Rпредставляет собой атом водорода или хлора, Rпредставляет собой атом водорода или алкильную, алкилкарбонильную или ароильную группу, Rи Rкаждый представляет собой алкоксигруппу, Rпредставляет собой алкоксигруппу, R, R, R, R, R, Rи Rимеют значения, указанные в описании. Лекарственные средства.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA021214794A CN1465566A (zh) | 2002-06-25 | 2002-06-25 | 青防己碱与青防己碱化合物、合成和用途 |
PCT/IB2003/002600 WO2004000815A1 (en) | 2002-06-25 | 2003-06-16 | Acutumine and acutumine compounds, synthesis and use |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500081A1 true EA200500081A1 (ru) | 2005-06-30 |
EA007229B1 EA007229B1 (ru) | 2006-08-25 |
Family
ID=29742994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500081A EA007229B1 (ru) | 2002-06-25 | 2003-06-16 | Акутумин и соединения акутумина, синтез и применение |
Country Status (20)
Country | Link |
---|---|
US (1) | US20060167076A1 (ru) |
EP (1) | EP1608625A1 (ru) |
JP (1) | JP2006501174A (ru) |
KR (1) | KR100677018B1 (ru) |
CN (2) | CN1465566A (ru) |
AR (1) | AR040462A1 (ru) |
AU (1) | AU2003242278A1 (ru) |
BR (1) | BR0312444A (ru) |
CA (1) | CA2491214A1 (ru) |
EA (1) | EA007229B1 (ru) |
GE (1) | GEP20074178B (ru) |
HK (1) | HK1077823A1 (ru) |
MA (1) | MA27264A1 (ru) |
MX (1) | MXPA05000076A (ru) |
NO (1) | NO20050214L (ru) |
NZ (1) | NZ537405A (ru) |
PL (1) | PL374039A1 (ru) |
UA (1) | UA80555C2 (ru) |
WO (1) | WO2004000815A1 (ru) |
ZA (1) | ZA200410280B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101820541B1 (ko) * | 2009-09-09 | 2018-02-28 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 8-옥소디히드로퓨린 유도체 |
AU2014101153A4 (en) * | 2014-01-03 | 2014-10-23 | Macau University Of Science And Technology | A Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions Thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3479423D1 (en) * | 1984-02-29 | 1989-09-21 | Covex Sa | Citrate of vinpocetine, and process for its preparation |
CN1052225A (zh) * | 1990-02-07 | 1991-06-12 | 福建省仙游电机厂 | 一种大比功的汽车发电机及其制造方法 |
CN1101812C (zh) * | 1997-12-19 | 2003-02-19 | 中国科学院上海药物研究所 | 石菖蒲中菖蒲碱及它们的用途 |
-
2002
- 2002-06-25 CN CNA021214794A patent/CN1465566A/zh active Pending
-
2003
- 2003-06-16 BR BR0312444-4A patent/BR0312444A/pt not_active IP Right Cessation
- 2003-06-16 JP JP2004515147A patent/JP2006501174A/ja active Pending
- 2003-06-16 PL PL03374039A patent/PL374039A1/xx not_active Application Discontinuation
- 2003-06-16 EP EP03732907A patent/EP1608625A1/en not_active Withdrawn
- 2003-06-16 US US10/519,418 patent/US20060167076A1/en not_active Abandoned
- 2003-06-16 UA UAA200500667A patent/UA80555C2/uk unknown
- 2003-06-16 CA CA002491214A patent/CA2491214A1/en not_active Abandoned
- 2003-06-16 CN CNB038191261A patent/CN1303069C/zh not_active Expired - Fee Related
- 2003-06-16 GE GEAP8597A patent/GEP20074178B/en unknown
- 2003-06-16 WO PCT/IB2003/002600 patent/WO2004000815A1/en active Application Filing
- 2003-06-16 KR KR1020047021154A patent/KR100677018B1/ko not_active IP Right Cessation
- 2003-06-16 NZ NZ537405A patent/NZ537405A/xx unknown
- 2003-06-16 AU AU2003242278A patent/AU2003242278A1/en not_active Abandoned
- 2003-06-16 MX MXPA05000076A patent/MXPA05000076A/es not_active Application Discontinuation
- 2003-06-16 EA EA200500081A patent/EA007229B1/ru not_active IP Right Cessation
- 2003-06-23 AR AR20030102234A patent/AR040462A1/es unknown
-
2004
- 2004-12-21 ZA ZA200410280A patent/ZA200410280B/en unknown
-
2005
- 2005-01-13 NO NO20050214A patent/NO20050214L/no not_active Application Discontinuation
- 2005-01-24 MA MA28062A patent/MA27264A1/fr unknown
- 2005-11-07 HK HK05109900A patent/HK1077823A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1077823A1 (en) | 2006-02-24 |
WO2004000815A1 (en) | 2003-12-31 |
KR20050058999A (ko) | 2005-06-17 |
EP1608625A1 (en) | 2005-12-28 |
AR040462A1 (es) | 2005-04-06 |
KR100677018B1 (ko) | 2007-01-31 |
JP2006501174A (ja) | 2006-01-12 |
MA27264A1 (fr) | 2005-03-01 |
CA2491214A1 (en) | 2003-12-31 |
GEP20074178B (en) | 2007-08-10 |
CN1303069C (zh) | 2007-03-07 |
MXPA05000076A (es) | 2005-04-08 |
CN1675183A (zh) | 2005-09-28 |
US20060167076A1 (en) | 2006-07-27 |
UA80555C2 (en) | 2007-10-10 |
NO20050214L (no) | 2005-01-13 |
AU2003242278A1 (en) | 2004-01-06 |
ZA200410280B (en) | 2006-07-26 |
EA007229B1 (ru) | 2006-08-25 |
NZ537405A (en) | 2006-03-31 |
BR0312444A (pt) | 2005-05-10 |
CN1465566A (zh) | 2004-01-07 |
PL374039A1 (en) | 2005-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |