EA200600060A1 - Аминосульфонилзамещенные 4-(аминометил) пиперидинбензамиды в качестве 5нт-антагонистов - Google Patents
Аминосульфонилзамещенные 4-(аминометил) пиперидинбензамиды в качестве 5нт-антагонистовInfo
- Publication number
- EA200600060A1 EA200600060A1 EA200600060A EA200600060A EA200600060A1 EA 200600060 A1 EA200600060 A1 EA 200600060A1 EA 200600060 A EA200600060 A EA 200600060A EA 200600060 A EA200600060 A EA 200600060A EA 200600060 A1 EA200600060 A1 EA 200600060A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- piperidinbenzamides
- aminomethil
- antagonists
- aminosulphonyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение касается новых соединений формулы (I), проявляющих антагонистические свойства относительно 5НТ-рецепторов. Изобретение также относится к способам получения таких новых соединений, фармацевтическим композициям, содержащим указанные новые соединения, а также к применению указанных соединений в качестве лекарственных средств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0350238 | 2003-06-19 | ||
PCT/EP2004/006280 WO2005000837A1 (en) | 2003-06-19 | 2004-06-10 | Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600060A1 true EA200600060A1 (ru) | 2006-06-30 |
EA009259B1 EA009259B1 (ru) | 2007-12-28 |
Family
ID=33547569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600060A EA009259B1 (ru) | 2003-06-19 | 2004-06-10 | Аминосульфонилзамещенные 4-(аминометил)пиперидинбензамиды в качестве 5ht-антагонистов |
Country Status (9)
Country | Link |
---|---|
US (2) | US7652040B2 (ru) |
EP (2) | EP1641783B1 (ru) |
JP (1) | JP4916878B2 (ru) |
KR (1) | KR101151642B1 (ru) |
AU (1) | AU2004251823B2 (ru) |
CA (1) | CA2526079C (ru) |
EA (1) | EA009259B1 (ru) |
PL (1) | PL1641783T3 (ru) |
WO (1) | WO2005000837A1 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2526079C (en) * | 2003-06-19 | 2012-01-10 | Janssen Pharmaceutica N.V. | Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists |
TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
US7728006B2 (en) | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
DE602005016446D1 (de) | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
DE602005014566D1 (de) | 2004-11-05 | 2009-07-02 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
CA2588037A1 (en) | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
NZ560828A (en) | 2005-03-02 | 2011-01-28 | Theravance Inc | Quinolinone compounds as 5-HT4 receptor agonists |
GB0901487D0 (en) | 2009-01-30 | 2009-03-11 | Movetis N V | Asthma Therapy |
US8992959B2 (en) | 2010-12-10 | 2015-03-31 | Medline Industries, Inc. | Articles having antimicrobial properties and methods of manufacturing the same |
JP6522502B2 (ja) | 2013-07-29 | 2019-05-29 | 協和発酵キリン株式会社 | Wntシグナル阻害剤 |
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US4186135A (en) * | 1976-08-04 | 1980-01-29 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation |
US4233263A (en) * | 1979-04-02 | 1980-11-11 | Northwestern University | Method of maintaining bacterial sterility in urine drainage bags |
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US5624704A (en) * | 1995-04-24 | 1997-04-29 | Baylor College Of Medicine | Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent |
US5820607A (en) * | 1995-06-05 | 1998-10-13 | Board Of Regents, University Of Texas Systems | Multipurpose anti-microbial silastic sheath system for the prevention of device-related infections |
US5709672A (en) * | 1995-11-01 | 1998-01-20 | Texas Tech University Health Sciences Center | Silastic and polymer-based catheters with improved antimicrobial/antifungal properties |
US6558686B1 (en) * | 1995-11-08 | 2003-05-06 | Baylor College Of Medicine | Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor |
US5756145A (en) * | 1995-11-08 | 1998-05-26 | Baylor College Of Medicine | Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor |
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US6358557B1 (en) * | 1999-09-10 | 2002-03-19 | Sts Biopolymers, Inc. | Graft polymerization of substrate surfaces |
US6261457B1 (en) * | 1999-11-12 | 2001-07-17 | Minntech Corporation | Method and product for cleaning hollow fiber material and filter |
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DE60221496D1 (de) * | 2001-01-12 | 2007-09-13 | Univ Texas | Neue antiseptische derivate mit breitem antimikrobiellem wirkungsspektrum zur imprägnierung von oberflächen |
US20030065292A1 (en) * | 2001-06-08 | 2003-04-03 | Darouiche Rabih O. | Ozonated medical devices and methods of using ozone to prevent complications from indwelling medical devices |
CA2528522C (en) * | 2003-06-06 | 2016-07-12 | Board Of Regents, The University Of Texas System | Antimicrobial flush solutions |
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CA2526079C (en) * | 2003-06-19 | 2012-01-10 | Janssen Pharmaceutica N.V. | Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists |
AU2004254193B2 (en) * | 2003-06-19 | 2010-02-18 | Janssen Pharmaceutica N.V. | 5ht4-antagonistic 4-(aminomethyl)-piperidine benzamides |
JP2007522835A (ja) * | 2004-01-20 | 2007-08-16 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 医療装置に消毒組成物をコーティングする、および含浸させる方法 |
-
2004
- 2004-06-10 CA CA2526079A patent/CA2526079C/en not_active Expired - Fee Related
- 2004-06-10 WO PCT/EP2004/006280 patent/WO2005000837A1/en active Search and Examination
- 2004-06-10 JP JP2006515884A patent/JP4916878B2/ja not_active Expired - Fee Related
- 2004-06-10 AU AU2004251823A patent/AU2004251823B2/en not_active Ceased
- 2004-06-10 EP EP04739781A patent/EP1641783B1/en not_active Expired - Lifetime
- 2004-06-10 PL PL04739781T patent/PL1641783T3/pl unknown
- 2004-06-10 EP EP10183296A patent/EP2305254A1/en not_active Withdrawn
- 2004-06-10 US US10/560,300 patent/US7652040B2/en not_active Expired - Fee Related
- 2004-06-10 EA EA200600060A patent/EA009259B1/ru not_active IP Right Cessation
-
2005
- 2005-11-23 KR KR1020057022390A patent/KR101151642B1/ko active IP Right Grant
-
2009
- 2009-12-08 US US12/633,122 patent/US8334304B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20100087483A1 (en) | 2010-04-08 |
JP4916878B2 (ja) | 2012-04-18 |
EP2305254A1 (en) | 2011-04-06 |
EA009259B1 (ru) | 2007-12-28 |
KR101151642B1 (ko) | 2012-06-08 |
EP1641783A1 (en) | 2006-04-05 |
CA2526079C (en) | 2012-01-10 |
AU2004251823B2 (en) | 2010-06-03 |
CA2526079A1 (en) | 2005-01-06 |
AU2004251823A1 (en) | 2005-01-06 |
US7652040B2 (en) | 2010-01-26 |
EP1641783B1 (en) | 2012-03-28 |
JP2007526875A (ja) | 2007-09-20 |
US8334304B2 (en) | 2012-12-18 |
WO2005000837A1 (en) | 2005-01-06 |
KR20060018230A (ko) | 2006-02-28 |
US20060142339A1 (en) | 2006-06-29 |
PL1641783T3 (pl) | 2012-08-31 |
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