MA27264A1 - Acutumine et dérivés d'acutumine, synthèse et utilisation - Google Patents

Acutumine et dérivés d'acutumine, synthèse et utilisation

Info

Publication number
MA27264A1
MA27264A1 MA28062A MA28062A MA27264A1 MA 27264 A1 MA27264 A1 MA 27264A1 MA 28062 A MA28062 A MA 28062A MA 28062 A MA28062 A MA 28062A MA 27264 A1 MA27264 A1 MA 27264A1
Authority
MA
Morocco
Prior art keywords
acutumine
derivatives
synthesis
alkoxy group
hydrogen atom
Prior art date
Application number
MA28062A
Other languages
English (en)
Inventor
Guo-Wei Qin
Xi-Can Tang
Pierre Lestage
Daniel-Henri Caignard
Pierre Renard
Original Assignee
Shanghai Inst Materia Medica
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Inst Materia Medica, Servier Lab filed Critical Shanghai Inst Materia Medica
Publication of MA27264A1 publication Critical patent/MA27264A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

ACUTUMINE ET DERIVES D'ACUTUMINE, SYNTHESE ET UTILISATION L'invention concerne l'acutumine et ses dérivés, ainsi que les composés de formule (I) : dans laquelle „ R1 et R2 représentent un atome d'hydrogène ou forment ensemble une liaison supplémentaire, „ R3 représente un atome d'hydrogène ou un groupement alkoxy, „ R5 représente un atome d'hydrogène ou de chlore, „ R6 représente un atome d'hydrogène ou un groupement alkyle, alkylecarbonyle ou aroyle, „ R7 et R10 représentent un groupement alkoxy, „ R10 représente un groupement alkoxy, „ R4, R8, R9, R11, R12, R13 et R14 sont tels que définis dans la description. Médicaments
MA28062A 2002-06-25 2005-01-24 Acutumine et dérivés d'acutumine, synthèse et utilisation MA27264A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA021214794A CN1465566A (zh) 2002-06-25 2002-06-25 青防己碱与青防己碱化合物、合成和用途

Publications (1)

Publication Number Publication Date
MA27264A1 true MA27264A1 (fr) 2005-03-01

Family

ID=29742994

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28062A MA27264A1 (fr) 2002-06-25 2005-01-24 Acutumine et dérivés d'acutumine, synthèse et utilisation

Country Status (20)

Country Link
US (1) US20060167076A1 (fr)
EP (1) EP1608625A1 (fr)
JP (1) JP2006501174A (fr)
KR (1) KR100677018B1 (fr)
CN (2) CN1465566A (fr)
AR (1) AR040462A1 (fr)
AU (1) AU2003242278A1 (fr)
BR (1) BR0312444A (fr)
CA (1) CA2491214A1 (fr)
EA (1) EA007229B1 (fr)
GE (1) GEP20074178B (fr)
HK (1) HK1077823A1 (fr)
MA (1) MA27264A1 (fr)
MX (1) MXPA05000076A (fr)
NO (1) NO20050214L (fr)
NZ (1) NZ537405A (fr)
PL (1) PL374039A1 (fr)
UA (1) UA80555C2 (fr)
WO (1) WO2004000815A1 (fr)
ZA (1) ZA200410280B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011030798A1 (fr) * 2009-09-09 2011-03-17 大日本住友製薬株式会社 Dérivés de 8-oxodihydropurine
AU2014101153A4 (en) * 2014-01-03 2014-10-23 Macau University Of Science And Technology A Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions Thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3479423D1 (en) * 1984-02-29 1989-09-21 Covex Sa Citrate of vinpocetine, and process for its preparation
CN1052225A (zh) * 1990-02-07 1991-06-12 福建省仙游电机厂 一种大比功的汽车发电机及其制造方法
CN1101812C (zh) * 1997-12-19 2003-02-19 中国科学院上海药物研究所 石菖蒲中菖蒲碱及它们的用途

Also Published As

Publication number Publication date
ZA200410280B (en) 2006-07-26
KR100677018B1 (ko) 2007-01-31
EA200500081A1 (ru) 2005-06-30
HK1077823A1 (en) 2006-02-24
JP2006501174A (ja) 2006-01-12
CA2491214A1 (fr) 2003-12-31
US20060167076A1 (en) 2006-07-27
WO2004000815A1 (fr) 2003-12-31
AR040462A1 (es) 2005-04-06
GEP20074178B (en) 2007-08-10
PL374039A1 (en) 2005-09-19
NZ537405A (en) 2006-03-31
EA007229B1 (ru) 2006-08-25
NO20050214L (no) 2005-01-13
AU2003242278A1 (en) 2004-01-06
EP1608625A1 (fr) 2005-12-28
CN1465566A (zh) 2004-01-07
MXPA05000076A (es) 2005-04-08
UA80555C2 (en) 2007-10-10
BR0312444A (pt) 2005-05-10
CN1675183A (zh) 2005-09-28
KR20050058999A (ko) 2005-06-17
CN1303069C (zh) 2007-03-07

Similar Documents

Publication Publication Date Title
MA27573A1 (fr) Sinomenine et derives de sinomenine, synthese et utilisation.
MA28422B1 (fr) Derives de n- (1,5-diphenyl-1h-pyrazol-3-yl) sulfonamide avec une affinite pour les recepteurs cb1
TNSN05073A1 (fr) Quinazolinones spirocondensees nouvelles et leur utilisation comme inhibiteurs de phosphodiesterase
TNSN06075A1 (fr) Phenyl-ou pyridylamides servant d'antagonistes de la prostaglandine e2
MA27428A1 (fr) Derives de pyrimidine et leur utilisation en tant que modulateurs cb2
MA27347A1 (fr) Inhibiteurs de protease du vih, compositions les contenant, leurs utilisations pharmaceutiques et matieres pour leur synthese
HUP0203700A2 (hu) N-szubsztituált cianopirrolidinek és cukorbetegség-ellenes szerként való alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények
TNSN06358A1 (fr) Methyl-aryl-ou-heteroaryl-amides substitues
MA27668A1 (fr) 2,4-di(phenylamino) pyrimidines utilisees pour traiter des maladies neoplasiques, des troubles inflammatoires et des troubles du systeme immunitaire
ATE286027T1 (de) Fluorpyrazol-biphenylamide als fungizide
MA31989B1 (fr) Dérivés d'indolinone et procédés pour leur fabrication
MA31865B1 (fr) Dérivés isoxazolo-pyridine
MA30207B1 (fr) Modulateurs des recepteurs de la progesterone a base d'indole sulfonamide
MA27930A1 (fr) Derives de nicotinamide utiles comme inhibiteurs de pde4
MA27141A1 (fr) DERIVES DE 3-AZABICYCLO[3.1.0]HEXANE SERVANT D'ANTAGONISTES DES RECEPTEURS D'OPIOiDES
MA28286A1 (fr) Dérivés de 1-N-phenyl-amino-1H-imidazole et compositions pharmaceutiques les contenant
MA31742B1 (fr) Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique
DK0994854T3 (da) Fremgangsmåde til fremstilling af en substitueret perhydroisoindol
MA27852A1 (fr) Derives de 1-(alkylaminoalkyl-pyrolidin-/piperidinyl)-2,2-diphenylacetamide utilises comme antagonistes du recepteur muscarinique
DK1189900T3 (da) Heterocykliske aminopyrrolidinderivater som melatonerge lægemidler
RS50229B (sr) Analozi vitamina d3
MA27795A1 (fr) Derives d'amine cycliques, procedes de preparation de ceux-ci et compositions pharmaceutiques les contenant
MA27264A1 (fr) Acutumine et dérivés d'acutumine, synthèse et utilisation
AP2001002188A0 (en) 5HT1 antagonists for antidepressant therapy.
MA27104A1 (fr) Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent