BR0312444A - Acutumine e compostos de acutumine, sìntese e uso - Google Patents
Acutumine e compostos de acutumine, sìntese e usoInfo
- Publication number
- BR0312444A BR0312444A BR0312444-4A BR0312444A BR0312444A BR 0312444 A BR0312444 A BR 0312444A BR 0312444 A BR0312444 A BR 0312444A BR 0312444 A BR0312444 A BR 0312444A
- Authority
- BR
- Brazil
- Prior art keywords
- acutumine
- compounds
- synthesis
- acutumin
- alkoxy group
- Prior art date
Links
- FSXRARBVZZKCGJ-UHFFFAOYSA-N dauricumine Natural products OC1C(OC)=CC(=O)C11C2(CC(=O)C(OC)=C3OC)CCN(C)C23CC1Cl FSXRARBVZZKCGJ-UHFFFAOYSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- FSXRARBVZZKCGJ-FMAJMWNWSA-N Acutumine Chemical compound O[C@@H]1C(OC)=CC(=O)[C@@]11[C@@]2(CC(=O)C(OC)=C3OC)CCN(C)[C@@]23C[C@@H]1Cl FSXRARBVZZKCGJ-FMAJMWNWSA-N 0.000 title 2
- QHDJUCISALFSTI-XXLQSDOLSA-N acutumine Natural products CO[C@@H]1C(OC)=CC(=O)[C@@]11[C@@]2(CC(=O)C(OC)=C3OC)CCN(C)[C@@]23C[C@@H]1Cl QHDJUCISALFSTI-XXLQSDOLSA-N 0.000 title 1
- PXTPGGRVOOOTDS-UHFFFAOYSA-N Acutumin Natural products C1C(OC)=CC(=O)C21C1(CC(=O)C(OC)=C3OC)CCN(C)C13CC2Cl PXTPGGRVOOOTDS-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Abstract
"ACUTUMINA E COMPOSTOS DE ACUTUMINA, SìNTESE E USO". A presente invenção refere-se a acutumina e compostos do mesmo e também a compostos de fórmula (I) em que R~ 1~ e R~ 2~ cada representam um átomo de hidrogênio ou juntos formam uma ligação adicional, R~ 3~ representa um átomo de hidrogênio ou um grupamento alcóxi, R~ 3~ representa um átomo de hidrogênio ou cloro, R~ 6~ representa um átomo de hidrogênio ou um grupamento alquila, alquilcarbonila ou amila, R~ 7~ e R~ 10~ cada representam um grupamento alcóxi, RIO representa um grupamento alcóxi, R~ 4~, R~ 8~, R~ 9~, R~ 11~, R~ 12~, R~ 13~ e R~ 14~ São conforme definido na descrição.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021214794A CN1465566A (zh) | 2002-06-25 | 2002-06-25 | 青防己碱与青防己碱化合物、合成和用途 |
| PCT/IB2003/002600 WO2004000815A1 (en) | 2002-06-25 | 2003-06-16 | Acutumine and acutumine compounds, synthesis and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312444A true BR0312444A (pt) | 2005-05-10 |
Family
ID=29742994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312444-4A BR0312444A (pt) | 2002-06-25 | 2003-06-16 | Acutumine e compostos de acutumine, sìntese e uso |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060167076A1 (pt) |
| EP (1) | EP1608625A1 (pt) |
| JP (1) | JP2006501174A (pt) |
| KR (1) | KR100677018B1 (pt) |
| CN (2) | CN1465566A (pt) |
| AR (1) | AR040462A1 (pt) |
| AU (1) | AU2003242278A1 (pt) |
| BR (1) | BR0312444A (pt) |
| CA (1) | CA2491214A1 (pt) |
| EA (1) | EA007229B1 (pt) |
| GE (1) | GEP20074178B (pt) |
| HK (1) | HK1077823A1 (pt) |
| MA (1) | MA27264A1 (pt) |
| MX (1) | MXPA05000076A (pt) |
| NO (1) | NO20050214L (pt) |
| NZ (1) | NZ537405A (pt) |
| PL (1) | PL374039A1 (pt) |
| UA (1) | UA80555C2 (pt) |
| WO (1) | WO2004000815A1 (pt) |
| ZA (1) | ZA200410280B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011030798A1 (ja) * | 2009-09-09 | 2011-03-17 | 大日本住友製薬株式会社 | ８－オキソジヒドロプリン誘導体 |
| AU2014101153A4 (en) * | 2014-01-03 | 2014-10-23 | Macau University Of Science And Technology | A Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions Thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3479423D1 (en) * | 1984-02-29 | 1989-09-21 | Covex Sa | Citrate of vinpocetine, and process for its preparation |
| CN1052225A (zh) * | 1990-02-07 | 1991-06-12 | 福建省仙游电机厂 | 一种大比功的汽车发电机及其制造方法 |
| CN1101812C (zh) * | 1997-12-19 | 2003-02-19 | 中国科学院上海药物研究所 | 石菖蒲中菖蒲碱及它们的用途 |
-
2002
- 2002-06-25 CN CNA021214794A patent/CN1465566A/zh active Pending
-
2003
- 2003-06-16 CN CNB038191261A patent/CN1303069C/zh not_active Expired - Fee Related
- 2003-06-16 NZ NZ537405A patent/NZ537405A/xx unknown
- 2003-06-16 BR BR0312444-4A patent/BR0312444A/pt not_active IP Right Cessation
- 2003-06-16 KR KR1020047021154A patent/KR100677018B1/ko not_active IP Right Cessation
- 2003-06-16 UA UAA200500667A patent/UA80555C2/uk unknown
- 2003-06-16 EP EP03732907A patent/EP1608625A1/en not_active Withdrawn
- 2003-06-16 US US10/519,418 patent/US20060167076A1/en not_active Abandoned
- 2003-06-16 WO PCT/IB2003/002600 patent/WO2004000815A1/en active Application Filing
- 2003-06-16 JP JP2004515147A patent/JP2006501174A/ja active Pending
- 2003-06-16 PL PL03374039A patent/PL374039A1/xx not_active Application Discontinuation
- 2003-06-16 MX MXPA05000076A patent/MXPA05000076A/es not_active Application Discontinuation
- 2003-06-16 GE GEAP8597A patent/GEP20074178B/en unknown
- 2003-06-16 AU AU2003242278A patent/AU2003242278A1/en not_active Abandoned
- 2003-06-16 EA EA200500081A patent/EA007229B1/ru not_active IP Right Cessation
- 2003-06-16 CA CA002491214A patent/CA2491214A1/en not_active Abandoned
- 2003-06-23 AR AR20030102234A patent/AR040462A1/es unknown
-
2004
- 2004-12-21 ZA ZA200410280A patent/ZA200410280B/en unknown
-
2005
- 2005-01-13 NO NO20050214A patent/NO20050214L/no not_active Application Discontinuation
- 2005-01-24 MA MA28062A patent/MA27264A1/fr unknown
- 2005-11-07 HK HK05109900A patent/HK1077823A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL374039A1 (en) | 2005-09-19 |
| MXPA05000076A (es) | 2005-04-08 |
| KR100677018B1 (ko) | 2007-01-31 |
| CA2491214A1 (en) | 2003-12-31 |
| HK1077823A1 (en) | 2006-02-24 |
| MA27264A1 (fr) | 2005-03-01 |
| NO20050214L (no) | 2005-01-13 |
| AU2003242278A1 (en) | 2004-01-06 |
| CN1303069C (zh) | 2007-03-07 |
| EA007229B1 (ru) | 2006-08-25 |
| KR20050058999A (ko) | 2005-06-17 |
| UA80555C2 (en) | 2007-10-10 |
| NZ537405A (en) | 2006-03-31 |
| CN1675183A (zh) | 2005-09-28 |
| WO2004000815A1 (en) | 2003-12-31 |
| CN1465566A (zh) | 2004-01-07 |
| AR040462A1 (es) | 2005-04-06 |
| GEP20074178B (en) | 2007-08-10 |
| EA200500081A1 (ru) | 2005-06-30 |
| US20060167076A1 (en) | 2006-07-27 |
| JP2006501174A (ja) | 2006-01-12 |
| EP1608625A1 (en) | 2005-12-28 |
| ZA200410280B (en) | 2006-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A. E 7A. ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |