EA200400907A1 - Рекомбинантный альфа-фетопротеин, способ и средства для его получения, композиции на его основе и их применение - Google Patents

Рекомбинантный альфа-фетопротеин, способ и средства для его получения, композиции на его основе и их применение

Info

Publication number
EA200400907A1
EA200400907A1 EA200400907A EA200400907A EA200400907A1 EA 200400907 A1 EA200400907 A1 EA 200400907A1 EA 200400907 A EA200400907 A EA 200400907A EA 200400907 A EA200400907 A EA 200400907A EA 200400907 A1 EA200400907 A1 EA 200400907A1
Authority
EA
Eurasian Patent Office
Prior art keywords
afp
fetoprotein
preparation
compositions
basis
Prior art date
Application number
EA200400907A
Other languages
English (en)
Other versions
EA011606B1 (ru
Inventor
Сергей Владимирович Беневоленский
Алексей Николаевич МАРЧЕНКО
Дмитрий Георгиевич КОЗЛОВ
Сергей Сергеевич Зацепин
Людмила Николаевна Шингарова
Игорь Вячеславович Дудич
Лидия Николаевна Семенкова
Дмитрий Игоревич Дудич
Эдуард Борисович Татулов
Елена Ивановна Дудич
Original Assignee
Открытое Акционерное Общество "Био-Система"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Открытое Акционерное Общество "Био-Система" filed Critical Открытое Акционерное Общество "Био-Система"
Priority to EA200400907A priority Critical patent/EA011606B1/ru
Priority to US11/632,409 priority patent/US7910327B2/en
Priority to DK05764041.9T priority patent/DK1807518T3/da
Priority to CN2005800261655A priority patent/CN1993469B/zh
Priority to ES05764041T priority patent/ES2384863T3/es
Priority to JP2007521429A priority patent/JP2008506384A/ja
Priority to PCT/RU2005/000369 priority patent/WO2006009492A1/en
Priority to PT05764041T priority patent/PT1807518E/pt
Priority to AT05764041T priority patent/ATE555205T1/de
Priority to EP05764041A priority patent/EP1807518B1/en
Publication of EA200400907A1 publication Critical patent/EA200400907A1/ru
Publication of EA011606B1 publication Critical patent/EA011606B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к микробиологической и медицинской промышленности, генной инженерии, биотехнологии. На основе конструирования рекомбинантной плазмидной ДНК, содержащей структурный ген альфа-фетопротеина (АФП) человека под контролем регулируемого промотора, получен штамм дрожжей Saccharomyces cerevisiae, обеспечивающей синтез и продукцию в секретируемой растворимой форме АФП, обладающего активностью, идентичной или аналогичной активности АФП человека. Полученный рекомбинантный АФП может быть использован в качестве активного вещества для приготовления терапевтических средств для применения в онкологии, иммунотерапии, косметологии и также для диагностики рака и эмбриональных патологий.
EA200400907A 2004-07-14 2004-07-14 Способы получения и применения рекомбинантного альфа-фетопротеина EA011606B1 (ru)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EA200400907A EA011606B1 (ru) 2004-07-14 2004-07-14 Способы получения и применения рекомбинантного альфа-фетопротеина
US11/632,409 US7910327B2 (en) 2004-07-14 2005-07-07 Recombinant alpha-fetoprotein and method of preparing
DK05764041.9T DK1807518T3 (da) 2004-07-14 2005-07-07 Rekombinant alfa-fetoprotein, fremgangsmåde og midler til fremstilling heraf, sammensætninger baseret derpå og anvendelse heraf
CN2005800261655A CN1993469B (zh) 2004-07-14 2005-07-07 重组甲胎蛋白，其制备方法及手段，以其为基础的组合物及其用途
ES05764041T ES2384863T3 (es) 2004-07-14 2005-07-07 Alfa-fetoproteína recombinante, procedimiento y medios para la preparación de la misma, composiciones basadas en la misma y uso de la misma
JP2007521429A JP2008506384A (ja) 2004-07-14 2005-07-07 組換えα−フェトプロテイン、その調製のための方法及び手段、それをベースとした組成物、及びその使用
PCT/RU2005/000369 WO2006009492A1 (en) 2004-07-14 2005-07-07 Recombinant alpha-fetoprotein, method and means for preparation thereof, compositions on the base thereof and use thereof
PT05764041T PT1807518E (pt) 2004-07-14 2005-07-07 Alfa-fetoproteína recombinante, método e meios para a sua preparação, composições baseadas na mesma e sua utilização
AT05764041T ATE555205T1 (de) 2004-07-14 2005-07-07 Rekombinantes alpha-fetoprotein, verfahren und mittel zur herstellung davon, zusammensetzungen auf basis davon und verwendung davon
EP05764041A EP1807518B1 (en) 2004-07-14 2005-07-07 Recombinant alpha-fetoprotein, method and means for preparation thereof, compositions on the base thereof and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA200400907A EA011606B1 (ru) 2004-07-14 2004-07-14 Способы получения и применения рекомбинантного альфа-фетопротеина

Publications (2)

Publication Number Publication Date
EA200400907A1 true EA200400907A1 (ru) 2006-02-24
EA011606B1 EA011606B1 (ru) 2009-04-28

Family

ID=35785507

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400907A EA011606B1 (ru) 2004-07-14 2004-07-14 Способы получения и применения рекомбинантного альфа-фетопротеина

Country Status (10)

Country Link
US (1) US7910327B2 (ru)
EP (1) EP1807518B1 (ru)
JP (1) JP2008506384A (ru)
CN (1) CN1993469B (ru)
AT (1) ATE555205T1 (ru)
DK (1) DK1807518T3 (ru)
EA (1) EA011606B1 (ru)
ES (1) ES2384863T3 (ru)
PT (1) PT1807518E (ru)
WO (1) WO2006009492A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070111936A1 (en) * 2005-11-15 2007-05-17 Vladimir Pak Complex of alpha-fetoprotein and inducers of apoptosis for the treatment of cancer
CA2670341C (en) * 2006-11-28 2015-05-26 University Of Central Florida Research Foundation, Inc. Vigor enhancement via administration of pyrimidine derivatives
US8791128B2 (en) 2008-09-16 2014-07-29 University Of Central Florida Research Foundation, Inc. Compositions for treating or delaying the onset of hair loss
KR101259564B1 (ko) * 2009-02-11 2013-04-30 건국대학교 산학협력단 항산화 활성을 가지는 피부 보호용 조성물
CN102993292A (zh) * 2012-12-14 2013-03-27 上海柯莱逊生物技术有限公司 一种afp重组蛋白和体外重组表达的方法
FI20130341L (fi) 2013-11-19 2015-05-20 Safemed Ltd Oy Huonosti vesiliukoisten lääkeaineiden kuljetus metalli-ioneilla tasapainotetun alfafetoproteiinin mukana
RU2617943C2 (ru) * 2015-07-17 2017-04-28 Общество с ограниченной ответственностью "Научно-производственное предприятие "Ферментные технологии" (ООО "НПП "Ферментные технологии") Рекомбинантный фрагмент ДНК, кодирующий альфа-фетопротеин (АФП) человека, содержащий "медленные" кодоны, кодирующие лейцин, экспрессионная плазмида, содержащая указанный фрагмент, клетка Saccharomyces cerevisiae, трансформированная указанной плазмидой, и способ получения рекомбинантного АФП человека

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US2559592A (en) * 1947-02-21 1951-07-10 Leslie M Button Vapor or fog nozzle
GB718847A (en) * 1952-09-25 1954-11-24 Allman Patents Ltd Improvements in spraying apparatus
GB798645A (en) * 1955-08-05 1958-07-23 Dorman Sprayer Company Ltd Improvements in or relating to spraying nozzles
GB1007304A (en) * 1963-09-16 1965-10-13 Ici Australia Ltd Nozzle
DE2554723C3 (de) * 1975-12-05 1978-11-23 Hans Grohe Gmbh & Co Kg, 7622 Schiltach Schwallbrause
DE2654228C3 (de) * 1976-11-30 1979-05-23 Robert Bosch Gmbh, 7000 Stuttgart Waschanlage für Abdeckscheiben von Kraftfahrzeugleuchten
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US5139936A (en) * 1983-02-28 1992-08-18 Collaborative Research, Inc. Use of the GAL1 yeast promoter
FR2624149B1 (fr) * 1987-12-04 1991-04-26 Planchon Alain Guide-jet plat divergent pour installation sanitaire
US5206153A (en) * 1990-06-27 1993-04-27 Snow Brand Milk Products Co., Ltd. Method of producing human α-fetoprotein and product produced thereby
CA2120131A1 (en) * 1991-09-27 1994-05-11 Robert A. Murgita Expression and purification of cloned human alpha-fetoprotein
US6331611B1 (en) * 1991-09-27 2001-12-18 Mcgill University Expression and purification of cloned human alpha-fetoprotein
US5965528A (en) * 1991-09-27 1999-10-12 Mcgill University Recombinant human alph-fetoprotein as an immunosuppressive agent
US6288034B1 (en) * 1995-01-24 2001-09-11 Martinex R & D Inc. Recombinant human alpha-fetoprotein as an immunosuppressive agent
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Also Published As

Publication number Publication date
EP1807518A1 (en) 2007-07-18
ES2384863T3 (es) 2012-07-13
EA011606B1 (ru) 2009-04-28
WO2006009492A8 (en) 2006-04-27
US20090233849A1 (en) 2009-09-17
JP2008506384A (ja) 2008-03-06
US7910327B2 (en) 2011-03-22
CN1993469A (zh) 2007-07-04
EP1807518B1 (en) 2012-04-25
ATE555205T1 (de) 2012-05-15
WO2006009492A1 (en) 2006-01-26
EP1807518A4 (en) 2008-04-16
DK1807518T3 (da) 2012-07-30
CN1993469B (zh) 2011-07-20
PT1807518E (pt) 2012-07-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY RU