EA200301020A1 - НОВЫЕ СОЕДИНЕНИЯ{3,4-a:3,4-c}КАРБАЗОЛА,СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ - Google Patents

НОВЫЕ СОЕДИНЕНИЯ{3,4-a:3,4-c}КАРБАЗОЛА,СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ

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Publication number
EA200301020A1
EA200301020A1 EA200301020A EA200301020A EA200301020A1 EA 200301020 A1 EA200301020 A1 EA 200301020A1 EA 200301020 A EA200301020 A EA 200301020A EA 200301020 A EA200301020 A EA 200301020A EA 200301020 A1 EA200301020 A1 EA 200301020A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
carbazole
production
pharmaceutical compositions
compositions containing
Prior art date
Application number
EA200301020A
Other languages
English (en)
Other versions
EA007250B1 (ru
Inventor
Мишель Прюдомм
Бернадетт Югон
Фабрис Анизон
Джон Хикман
Ален Пьер
Роу Голштейн
Пьер Ренар
Бруно Пфайффер
Original Assignee
Ле Лаборатур Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатур Сервье filed Critical Ле Лаборатур Сервье
Publication of EA200301020A1 publication Critical patent/EA200301020A1/ru
Publication of EA007250B1 publication Critical patent/EA007250B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Соединения формулы (I)в которойWвместе с атомами углерода, с которыми он связан, представляет собой фенильную группу или пиридильную группу,Z представляет собой группу формулы U-V, такую как определено в описании,Qпредставляет собой атом кислорода или группу NR, такую как определено в описании,Qпредставляет собой атом кислорода или группу NR', такую как определено в описании,X, X, X'и X', каждый, представляет собой атом водорода или гидрокси, алкокси, меркапто или алкилтиогруппу,Y, Y, Y'и Y', каждый, представляет собой атом водорода,или Xи Y, Xи Y, X'и Y', X'и Y'с атомом углерода, несущим их, вместе образуют карбонильную или тиокарбонильную группу,Rтакой, как определено в описании. Лекарственные средства.
EA200301020A 2002-10-16 2003-10-15 НОВЫЕ СОЕДИНЕНИЯ[3,4-а:3,4-с]КАРБАЗОЛА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ,СОДЕРЖАЩИЕ ИХ EA007250B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0212847A FR2845996A1 (fr) 2002-10-16 2002-10-16 Nouveaux derives de[3,4-a:3,4-c]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200301020A1 true EA200301020A1 (ru) 2004-04-29
EA007250B1 EA007250B1 (ru) 2006-08-25

Family

ID=29725330

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301020A EA007250B1 (ru) 2002-10-16 2003-10-15 НОВЫЕ СОЕДИНЕНИЯ[3,4-а:3,4-с]КАРБАЗОЛА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ,СОДЕРЖАЩИЕ ИХ

Country Status (26)

Country Link
US (1) US7151108B2 (ru)
EP (1) EP1411057B1 (ru)
JP (1) JP2004277404A (ru)
KR (1) KR100502250B1 (ru)
CN (1) CN1241925C (ru)
AR (1) AR041618A1 (ru)
AT (1) ATE294181T1 (ru)
AU (1) AU2003254746A1 (ru)
BR (1) BR0304575A (ru)
CA (1) CA2443585A1 (ru)
DE (1) DE60300571T2 (ru)
DK (1) DK1411057T3 (ru)
EA (1) EA007250B1 (ru)
ES (1) ES2240927T3 (ru)
FR (1) FR2845996A1 (ru)
HK (1) HK1063321A1 (ru)
MA (1) MA27007A1 (ru)
MX (1) MXPA03009362A (ru)
MY (1) MY134620A (ru)
NO (1) NO20034614L (ru)
NZ (1) NZ528902A (ru)
PL (1) PL362885A1 (ru)
PT (1) PT1411057E (ru)
SG (1) SG131765A1 (ru)
SI (1) SI1411057T1 (ru)
ZA (1) ZA200308053B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499414B (zh) * 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
WO2008109591A1 (en) 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
EP3105225A1 (en) 2014-02-12 2016-12-21 iTeos Therapeutics Novel 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use
CN103804278B (zh) * 2014-02-19 2016-04-13 西北大学 一种天然产物2-甲基-3-甲氧基-咔唑-1,4-苯醌的制备方法
MX2016015005A (es) 2014-05-15 2017-09-28 Iteos Therapeutics Derivados de pirrolidina-2,5-diona, composiciones farmaceuticas y metodos para usar como inhibidores ido1.
KR102013512B1 (ko) 2015-03-17 2019-08-22 화이자 인코포레이티드 신규 3-인돌 치환 유도체, 제약 조성물 및 사용 방법
JP2016216446A (ja) * 2015-05-14 2016-12-22 ファイザー・インク ピロリジン−２，５−ジオン誘導体の多形形態、医薬組成物、およびｉｄｏ１阻害薬としての使用方法
EP3334733A1 (en) 2015-08-10 2018-06-20 Pfizer Inc 3-indol substituted derivatives, pharmaceutical compositions and methods for use
CN106832175B (zh) * 2017-02-17 2019-10-18 华南理工大学 一种基于咔唑衍生物的双羟基荧光扩链剂及其制备与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3010675B2 (ja) * 1989-03-23 2000-02-21 萬有製薬株式会社 抗腫瘍性物質ｂｅ―１３７９３ｃ

Also Published As

Publication number Publication date
KR20040034472A (ko) 2004-04-28
SG131765A1 (en) 2007-05-28
EP1411057B1 (fr) 2005-04-27
US20040077672A1 (en) 2004-04-22
PT1411057E (pt) 2005-08-31
ATE294181T1 (de) 2005-05-15
AR041618A1 (es) 2005-05-26
NO20034614L (no) 2004-04-19
DK1411057T3 (da) 2005-08-29
FR2845996A1 (fr) 2004-04-23
MA27007A1 (fr) 2004-12-20
DE60300571T2 (de) 2006-02-23
NO20034614D0 (no) 2003-10-15
PL362885A1 (en) 2004-04-19
JP2004277404A (ja) 2004-10-07
AU2003254746A1 (en) 2004-05-06
MY134620A (en) 2007-12-31
CN1241925C (zh) 2006-02-15
DE60300571D1 (de) 2005-06-02
EA007250B1 (ru) 2006-08-25
HK1063321A1 (en) 2004-12-24
CN1496989A (zh) 2004-05-19
ES2240927T3 (es) 2005-10-16
KR100502250B1 (ko) 2005-07-20
EP1411057A1 (fr) 2004-04-21
US7151108B2 (en) 2006-12-19
MXPA03009362A (es) 2004-04-28
CA2443585A1 (fr) 2004-04-16
BR0304575A (pt) 2004-07-20
ZA200308053B (en) 2004-07-08
SI1411057T1 (ru) 2005-08-31
NZ528902A (en) 2004-09-24

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