EA200101159A1 - Произодное аминотетралина для терапии сердечно-сосудистых заболеваний - Google Patents

Произодное аминотетралина для терапии сердечно-сосудистых заболеваний

Info

Publication number
EA200101159A1
EA200101159A1 EA200101159A EA200101159A EA200101159A1 EA 200101159 A1 EA200101159 A1 EA 200101159A1 EA 200101159 A EA200101159 A EA 200101159A EA 200101159 A EA200101159 A EA 200101159A EA 200101159 A1 EA200101159 A1 EA 200101159A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aminotothaline
therapy
derivative
cardiovascular diseases
methylaminotetralin
Prior art date
Application number
EA200101159A
Other languages
English (en)
Other versions
EA003830B1 (ru
Inventor
Стефано Бонграни
Роберта Радзетти
Маурицио Чивелли
Альберто Умиле
Паоло Кьези
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/328,434 external-priority patent/US6103760A/en
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority claimed from PCT/EP2000/005231 external-priority patent/WO2000076544A1/en
Publication of EA200101159A1 publication Critical patent/EA200101159A1/ru
Publication of EA003830B1 publication Critical patent/EA003830B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Дисфункцию левого желудочка лечат способом, при котором субъекту, страдающему ремоделированием левого желудочка, вводят терапевтически эффективное количество 5,6-дигидрокси-2-метиламинотетралина, или 5,6-диизобутироил-окси-2-метиламинотетралина, или его фармацевтически приемлемой соли в комбинации с ингибитором ангиотензинпревращающего фермента.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200101159A 1999-06-09 2000-06-07 Производное аминотетралина для терапии сердечно-сосудистых заболеваний EA003830B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/328,434 US6103760A (en) 1995-03-17 1999-06-09 Aminotetralin derivative for the therapy of cardiovascular diseases
PCT/EP2000/005231 WO2000076544A1 (en) 1996-03-13 2000-06-07 Aminotetralin derivative for the therapy of cardiovascular diseases

Publications (2)

Publication Number Publication Date
EA200101159A1 true EA200101159A1 (ru) 2002-06-27
EA003830B1 EA003830B1 (ru) 2003-10-30

Family

ID=23280968

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200101159A EA003830B1 (ru) 1999-06-09 2000-06-07 Производное аминотетралина для терапии сердечно-сосудистых заболеваний

Country Status (27)

Country Link
US (2) US6576671B1 (ru)
EP (1) EP1183046B1 (ru)
JP (1) JP2003501483A (ru)
KR (1) KR20020005772A (ru)
CN (1) CN1354676A (ru)
AT (1) ATE248607T1 (ru)
AU (1) AU766230B2 (ru)
BR (1) BR0012121A (ru)
CA (1) CA2376715A1 (ru)
CZ (1) CZ20014406A3 (ru)
DE (1) DE60004996T2 (ru)
DK (1) DK1183046T3 (ru)
EA (1) EA003830B1 (ru)
EE (1) EE200100663A (ru)
ES (1) ES2206240T3 (ru)
HK (1) HK1044279B (ru)
HU (1) HUP0201650A2 (ru)
IL (1) IL146962A0 (ru)
MA (1) MA26796A1 (ru)
MX (1) MXPA01012638A (ru)
NO (1) NO20016000L (ru)
NZ (1) NZ515727A (ru)
PL (1) PL352119A1 (ru)
PT (1) PT1183046E (ru)
SK (1) SK18012001A3 (ru)
TR (1) TR200103526T2 (ru)
ZA (1) ZA200110091B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10053397A1 (de) * 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10064453A1 (de) * 2000-12-16 2002-07-04 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
US20050101668A1 (en) * 2003-07-24 2005-05-12 Chiesi Farmaceutici S.P.A. Aminotetralin derivatives as a medicament for the treatment and prevention of myocardial ischemic conditions
EP1500392A1 (en) * 2003-07-24 2005-01-26 CHIESI FARMACEUTICI S.p.A. Aminotetralin derivatives as a medicament for the treatment and prevention of myocardial ischemic conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134997A (en) * 1977-03-01 1979-01-16 University Of Iowa Research Foundation Effect of an aminotetralin derivative on coronary blood flow in infarcted hearts
IT1275935B1 (it) 1995-03-17 1997-10-24 Chiesi Farma Spa Derivato di aminotetralina per la terapia di malattie cardiovascolari

Also Published As

Publication number Publication date
EP1183046B1 (en) 2003-09-03
ZA200110091B (en) 2002-12-09
ATE248607T1 (de) 2003-09-15
HK1044279A1 (en) 2002-10-18
PL352119A1 (en) 2003-07-28
AU766230B2 (en) 2003-10-09
TR200103526T2 (tr) 2002-04-22
DE60004996D1 (de) 2003-10-09
EA003830B1 (ru) 2003-10-30
EP1183046A1 (en) 2002-03-06
MXPA01012638A (es) 2002-07-22
DK1183046T3 (da) 2004-01-05
KR20020005772A (ko) 2002-01-17
ES2206240T3 (es) 2004-05-16
IL146962A0 (en) 2002-08-14
BR0012121A (pt) 2002-05-14
NO20016000D0 (no) 2001-12-07
US6576671B1 (en) 2003-06-10
JP2003501483A (ja) 2003-01-14
CA2376715A1 (en) 2000-12-21
CZ20014406A3 (cs) 2002-04-17
NZ515727A (en) 2003-06-30
MA26796A1 (fr) 2004-12-20
US20030207944A1 (en) 2003-11-06
EE200100663A (et) 2003-04-15
NO20016000L (no) 2002-02-11
HUP0201650A2 (hu) 2002-12-28
AU5076500A (en) 2001-01-02
CN1354676A (zh) 2002-06-19
DE60004996T2 (de) 2004-07-22
HK1044279B (zh) 2004-01-16
SK18012001A3 (sk) 2002-04-04
PT1183046E (pt) 2003-12-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU