EA200100133A1 - Оксазолидиноны для лечения инфекционных болезней глаз - Google Patents

Оксазолидиноны для лечения инфекционных болезней глаз

Info

Publication number
EA200100133A1
EA200100133A1 EA200100133A EA200100133A EA200100133A1 EA 200100133 A1 EA200100133 A1 EA 200100133A1 EA 200100133 A EA200100133 A EA 200100133A EA 200100133 A EA200100133 A EA 200100133A EA 200100133 A1 EA200100133 A1 EA 200100133A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
oxazolidinones
eye diseases
infectious eye
infectious
Prior art date
Application number
EA200100133A
Other languages
English (en)
Other versions
EA003274B1 (ru
Inventor
Роберт Кочран
Чарльз В. Форд
Original Assignee
Фармация Энд Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of EA200100133A1 publication Critical patent/EA200100133A1/ru
Publication of EA003274B1 publication Critical patent/EA003274B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение включает способ лечения глазной инфекции у полезных теплотворных млекопитающих, нуждающихся в таком лечении, который включает местное введение офтальмологически эффективного количества оксозолидинона.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100133A 1998-07-14 1999-07-07 Оксазолидиноны в качестве активного вещества при лечении инфекционных глазных болезней EA003274B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9276598P 1998-07-14 1998-07-14
PCT/US1999/012367 WO2000003710A1 (en) 1998-07-14 1999-07-07 Oxazolidinones to treat eye infections

Publications (2)

Publication Number Publication Date
EA200100133A1 true EA200100133A1 (ru) 2001-06-25
EA003274B1 EA003274B1 (ru) 2003-04-24

Family

ID=22235050

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100133A EA003274B1 (ru) 1998-07-14 1999-07-07 Оксазолидиноны в качестве активного вещества при лечении инфекционных глазных болезней

Country Status (27)

Country Link
US (2) US6337329B1 (ru)
EP (1) EP1096934B1 (ru)
JP (1) JP2002520359A (ru)
KR (1) KR20010079530A (ru)
CN (1) CN1305374A (ru)
AT (1) ATE304886T1 (ru)
AU (1) AU740781B2 (ru)
BG (1) BG64666B1 (ru)
BR (1) BR9912004A (ru)
CA (1) CA2334811A1 (ru)
DE (1) DE69927380T2 (ru)
DK (1) DK1096934T3 (ru)
EA (1) EA003274B1 (ru)
EE (1) EE200100026A (ru)
ES (1) ES2249020T3 (ru)
HU (1) HUP0102836A3 (ru)
ID (1) ID27276A (ru)
IL (1) IL140769A0 (ru)
NO (1) NO20010202L (ru)
NZ (1) NZ509375A (ru)
PL (1) PL345544A1 (ru)
PT (1) PT1096934E (ru)
SG (1) SG125079A1 (ru)
SK (1) SK20332000A3 (ru)
TR (1) TR200100066T2 (ru)
WO (1) WO2000003710A1 (ru)
ZA (1) ZA200100038B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR020660A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Composiciones antibioticas para el tratamiento de ojos, oidos y nariz
AU780671B2 (en) * 1999-09-13 2005-04-07 Sun Pharma Global Fze Topical treatment for prevention of ocular infections
US6562820B2 (en) 2000-07-05 2003-05-13 Pharmacia & Upjohn Company Method for treatment and prevention of mastitis
PE20020300A1 (es) * 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
AR031135A1 (es) * 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
US20030069235A1 (en) * 2001-09-14 2003-04-10 J. Greg Slatter Treatment for ocular infections
JP2005521691A (ja) * 2002-02-22 2005-07-21 ファルマシア・コーポレーション シクロデキストリン化合物及び塩化セチルピリジニウムを含有する眼科用抗菌性薬物製剤
TW201043267A (en) * 2009-03-19 2010-12-16 Intervet Int Bv In situ constituting a vaccine for administration to a predetermined herd of animals
CN101766628B (zh) * 2010-01-20 2012-07-04 广东宏盈科技有限公司 一种眼科外用抗细菌感染药物
CN108452316B (zh) * 2012-09-13 2022-04-15 星法马有限公司 眼部感染的治疗或预防方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164510A (en) 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
DK0610265T3 (da) 1991-11-01 1997-06-09 Upjohn Co Substituerede aryl- og heteroarylphenyloxazolidioner, som kan anvendes som antibakterielle midler
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1995014684A1 (en) 1993-11-22 1995-06-01 The Upjohn Company Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE69739907D1 (de) * 1996-05-31 2010-07-22 Scripps Research Inst 3 vermittelter angiogenesis hemmers

Also Published As

Publication number Publication date
HUP0102836A2 (hu) 2002-05-29
BG64666B1 (bg) 2005-11-30
US20020065280A1 (en) 2002-05-30
IL140769A0 (en) 2002-02-10
JP2002520359A (ja) 2002-07-09
BR9912004A (pt) 2001-04-10
NO20010202D0 (no) 2001-01-12
PT1096934E (pt) 2005-11-30
SG125079A1 (en) 2006-09-29
DE69927380D1 (de) 2005-10-27
PL345544A1 (en) 2001-12-17
NO20010202L (no) 2001-01-12
ES2249020T3 (es) 2006-03-16
EP1096934A1 (en) 2001-05-09
KR20010079530A (ko) 2001-08-22
ATE304886T1 (de) 2005-10-15
AU740781B2 (en) 2001-11-15
DE69927380T2 (de) 2006-07-06
EA003274B1 (ru) 2003-04-24
DK1096934T3 (da) 2005-11-28
CA2334811A1 (en) 2000-01-27
SK20332000A3 (sk) 2001-05-10
US6337329B1 (en) 2002-01-08
CN1305374A (zh) 2001-07-25
HUP0102836A3 (en) 2003-12-29
ID27276A (id) 2001-03-22
BG105142A (en) 2001-10-31
AU4953099A (en) 2000-02-07
EP1096934B1 (en) 2005-09-21
NZ509375A (en) 2003-11-28
US6740652B2 (en) 2004-05-25
ZA200100038B (en) 2002-01-02
EE200100026A (et) 2002-06-17
WO2000003710A1 (en) 2000-01-27
TR200100066T2 (tr) 2001-05-21

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