EA200001109A1 - Новые частицы, композиция на их основе и способ лечения с их применением - Google Patents

Новые частицы, композиция на их основе и способ лечения с их применением

Info

Publication number
EA200001109A1
EA200001109A1 EA200001109A EA200001109A EA200001109A1 EA 200001109 A1 EA200001109 A1 EA 200001109A1 EA 200001109 A EA200001109 A EA 200001109A EA 200001109 A EA200001109 A EA 200001109A EA 200001109 A1 EA200001109 A1 EA 200001109A1
Authority
EA
Eurasian Patent Office
Prior art keywords
basis
application
treatment
composition
mammals
Prior art date
Application number
EA200001109A
Other languages
English (en)
Inventor
Уолтер Перкинз
Дональд Херч
Эрик Мейхью
Имран Ахмад
Шаукат Али
Эндру Джанофф
Ли Сингонг
Original Assignee
ДЗЕ ЛИПОСОМ КОМПАНИ, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДЗЕ ЛИПОСОМ КОМПАНИ, Инк. filed Critical ДЗЕ ЛИПОСОМ КОМПАНИ, Инк.
Publication of EA200001109A1 publication Critical patent/EA200001109A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid

Abstract

Настоящее изобретение предлагает носители, способные доставлять высокие концентрации слабо гидрофильных и слабо липофильных соединений в организм млекопитающих путем комбинирования соединений, имеющих биологически совместимые гидрофобные области с конъюгатами, имеющими как гидрофобные, так и гидрофильные области. Указанные композиции могут найти ряд применений у млекопитающих, в частности для введения им высоких концентраций терапевтически активных соединений, не оказывая при этом нежелательного уровня побочных эффектов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001109A 1998-05-20 1999-05-19 Новые частицы, композиция на их основе и способ лечения с их применением EA200001109A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8610898P 1998-05-20 1998-05-20
PCT/US1999/010975 WO1999059550A1 (en) 1998-05-20 1999-05-19 Novel particulate formulations

Publications (1)

Publication Number Publication Date
EA200001109A1 true EA200001109A1 (ru) 2001-06-25

Family

ID=22196324

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001109A EA200001109A1 (ru) 1998-05-20 1999-05-19 Новые частицы, композиция на их основе и способ лечения с их применением

Country Status (18)

Country Link
US (1) US6500461B2 (ru)
EP (1) EP1079812A4 (ru)
JP (1) JP2002535242A (ru)
KR (1) KR20010052368A (ru)
CN (1) CN1310612A (ru)
AR (1) AR019308A1 (ru)
AU (1) AU745015B2 (ru)
BR (1) BR9911031A (ru)
CA (1) CA2332545A1 (ru)
EA (1) EA200001109A1 (ru)
EE (1) EE200000693A (ru)
ID (1) ID28166A (ru)
IL (1) IL139541A0 (ru)
NO (1) NO20005832L (ru)
PL (1) PL344327A1 (ru)
SK (1) SK17422000A3 (ru)
TR (1) TR200003435T2 (ru)
WO (1) WO1999059550A1 (ru)

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KR101752944B1 (ko) 2010-05-03 2017-07-03 테이코쿠 팔마 유에스에이, 인코포레이티드 비수성의 탁산 프로에멀젼 제제, 및 그의 제조 및 사용 방법
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Also Published As

Publication number Publication date
JP2002535242A (ja) 2002-10-22
EP1079812A4 (en) 2001-12-12
NO20005832D0 (no) 2000-11-17
AR019308A1 (es) 2002-02-13
IL139541A0 (en) 2004-02-08
CN1310612A (zh) 2001-08-29
SK17422000A3 (sk) 2001-09-11
ID28166A (id) 2001-05-10
TR200003435T2 (tr) 2001-03-21
US6500461B2 (en) 2002-12-31
EP1079812A1 (en) 2001-03-07
KR20010052368A (ko) 2001-06-25
AU4190699A (en) 1999-12-06
BR9911031A (pt) 2002-01-29
CA2332545A1 (en) 1999-11-25
EE200000693A (et) 2002-04-15
NO20005832L (no) 2001-01-18
WO1999059550A1 (en) 1999-11-25
US20020034536A1 (en) 2002-03-21
PL344327A1 (en) 2001-10-22
AU745015B2 (en) 2002-03-07

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