EA199900069A1 - Вакцинная композиция против малярии - Google Patents

Вакцинная композиция против малярии

Info

Publication number
EA199900069A1
EA199900069A1 EA199900069A EA199900069A EA199900069A1 EA 199900069 A1 EA199900069 A1 EA 199900069A1 EA 199900069 A EA199900069 A EA 199900069A EA 199900069 A EA199900069 A EA 199900069A EA 199900069 A1 EA199900069 A1 EA 199900069A1
Authority
EA
Eurasian Patent Office
Prior art keywords
vaccine composition
composition against
against malaria
malaria
adjuvant
Prior art date
Application number
EA199900069A
Other languages
English (en)
Other versions
EA002167B1 (ru
Inventor
Джозеф Коэн
Original Assignee
Смитклайн Бичем Байолоджикалз С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичем Байолоджикалз С.А. filed Critical Смитклайн Бичем Байолоджикалз С.А.
Publication of EA199900069A1 publication Critical patent/EA199900069A1/ru
Publication of EA002167B1 publication Critical patent/EA002167B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Вакцинная композиция, полезная при предупреждении или лечении малярии, содержит множество антигенов малярийного происхождения в комбинации с адъювантом, который является предпочтительным стимулятором ТН1 клеточного ответа.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900069A 1996-08-02 1997-07-31 Вакцинная композиция против малярии EA002167B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9616351.4A GB9616351D0 (en) 1996-08-02 1996-08-02 Vaccine composition
PCT/EP1997/004326 WO1998005355A1 (en) 1996-08-02 1997-07-31 Vaccine composition against malaria

Publications (2)

Publication Number Publication Date
EA199900069A1 true EA199900069A1 (ru) 1999-10-28
EA002167B1 EA002167B1 (ru) 2002-02-28

Family

ID=10797980

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900069A EA002167B1 (ru) 1996-08-02 1997-07-31 Вакцинная композиция против малярии

Country Status (32)

Country Link
US (2) US20020172692A1 (ru)
EP (2) EP1623720A3 (ru)
JP (1) JP2000517295A (ru)
KR (1) KR20000029747A (ru)
CN (1) CN1241639C (ru)
AP (1) AP1166A (ru)
AR (1) AR008799A1 (ru)
AT (1) ATE394119T1 (ru)
AU (1) AU706303B2 (ru)
BG (1) BG63290B1 (ru)
BR (1) BR9710913A (ru)
CA (1) CA2262402A1 (ru)
CO (1) CO4650186A1 (ru)
CZ (1) CZ290826B6 (ru)
DE (1) DE69738672D1 (ru)
DZ (1) DZ2283A1 (ru)
EA (1) EA002167B1 (ru)
GB (1) GB9616351D0 (ru)
ID (1) ID17860A (ru)
IL (1) IL128318A (ru)
MA (1) MA24291A1 (ru)
MY (1) MY116128A (ru)
NO (1) NO319844B1 (ru)
OA (1) OA10969A (ru)
PE (1) PE97298A1 (ru)
PL (1) PL188741B1 (ru)
SK (1) SK282438B6 (ru)
TR (1) TR199900195T2 (ru)
UA (1) UA68336C2 (ru)
UY (1) UY24654A1 (ru)
WO (1) WO1998005355A1 (ru)
ZA (1) ZA976815B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9915204D0 (en) * 1999-06-29 1999-09-01 Smithkline Beecham Biolog Vaccine
EP1569515A4 (en) 2002-10-23 2006-04-26 Glaxosmithkline Biolog Sa MALARIA vaccine method
CN1894273B (zh) * 2003-12-01 2011-01-12 明治乳业株式会社 血管紧张素转化酶抑制肽
GB0513421D0 (en) * 2005-06-30 2005-08-03 Glaxosmithkline Biolog Sa Vaccines
EA014314B1 (ru) * 2005-08-02 2010-10-29 Новартис Вэксинес Энд Дайэгностикс Срл Пониженная интерференция между маслосодержащими адъювантами и антигенами, содержащими поверхностно-активные вещества
SG173377A1 (en) * 2006-07-18 2011-08-29 Glaxosmithkline Biolog Sa Vaccines for malaria
GB0614254D0 (en) * 2006-07-18 2006-08-30 Smithkline Beecham Biolog Vaccine
EP2066344B2 (en) 2006-09-07 2016-06-29 GlaxoSmithKline Biologicals S.A. Inactivated Poliovirus combination vaccine
AP2010005166A0 (en) 2007-08-13 2010-02-28 Glaxosmithkline Biolog Sa Vaccines
CL2008003808A1 (es) * 2007-12-21 2011-03-11 Glaxosmithkline Biologicals Sa Componente de vacuna contra la malaria que comprende una particula inmunogena rts,s y/o una particula que se deriva de la proteina cs de una o mas cepas de p. vivax y el antigeno s de la hepatitis b o una particula inmunogena que comprende rts, csv-s y opcionalmente el antigeno s sin fusionar y un agente estabilizante ; y vacuna.
EP2234638A1 (en) * 2007-12-24 2010-10-06 GlaxoSmithKline Biologicals SA Vaccines for malaria
EP2313108A4 (en) * 2008-06-30 2013-06-12 Us Army As Represented By The Secretary Of The Army ANTIPALUDE VACCINE OF SELF-ASSEMBLED POLYPEPTIDE NANOPARTICLES
CA2769996C (en) * 2009-11-05 2018-06-12 The United States Of America As Represented By The Secretary Of The Na Plasmodium falciparum sporozoite and liver stage antigens
MX354752B (es) 2010-09-27 2018-03-20 Janssen Vaccines & Prevention Bv Regimen de vacunacion de sensibilizacion y refuerzo heterologo contra malaria.
GB201116248D0 (en) 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
US20130122038A1 (en) 2011-11-14 2013-05-16 The United States Of America As Represented By The Secretary Of The Department Heterologous prime-boost immunization using measles virus-based vaccines
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
CN104338129B (zh) * 2013-07-26 2017-05-24 中国科学院上海巴斯德研究所 雷帕霉素作为疫苗佐剂的用途及制备方法
JP7136777B2 (ja) 2016-12-07 2022-09-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 新規プロセス
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
GB2600653B (en) 2017-05-30 2022-11-02 Glaxosmithkline Biologicals Sa Novel methods
EP3717001A1 (en) 2017-12-01 2020-10-07 GlaxoSmithKline Biologicals S.A. Saponin purification
BR112021024363A2 (pt) 2019-06-05 2022-03-22 Glaxosmithkline Biologicals Sa Purificação de saponina

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071705B1 (en) * 1981-05-21 1989-11-23 The Wellcome Foundation Limited Protozoal antigen
ES8800273A1 (es) * 1985-03-28 1987-11-01 Univ New York Perfeccionamientos en la fabricacion de conjugados de proteinas portadores de antigenos inmunogenicos para vacunas contra la malaria
GB8819209D0 (en) * 1988-08-12 1988-09-14 Research Corp Ltd Polypeptide & dna encoding same
GB9012580D0 (en) * 1990-06-06 1990-07-25 Univ Nijmegen Novel protein
FR2679776A1 (fr) * 1991-07-31 1993-02-05 Pasteur Institut Melange de constituants peptidiques ayant des proprietes vaccinantes contre le paludisme, notamment du a plasmodium falciparum.
WO1993010152A1 (en) * 1991-11-16 1993-05-27 Smithkline Beecham Biologicals S.A. HYBRID PROTEIN BETWEEN CS FROM PLASMODIUM AND HBsAG
US6169171B1 (en) * 1992-02-27 2001-01-02 Smithkline Beecham Biologicals (S.A.) Hybrid protein between CS from plasmodium and HBSAG
HU219808B (hu) * 1992-06-25 2001-08-28 Smithkline Beecham Biologicals S.A. Adjuvánst tartalmazó vakcinakompozíció és eljárás annak előállítására
GB9326253D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
AUPM368994A0 (en) * 1994-02-04 1994-02-24 Saramane Pty Ltd Malaria merozoite antigen subunit vaccine
FR2744723A1 (fr) * 1996-02-14 1997-08-14 Pasteur Institut Proteine recombinante contenant un fragment c-terminal d'une proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques
FR2744724B1 (fr) * 1996-02-14 2002-08-02 Pasteur Institut Proteine recombinante contenant un fragment c-terminal de la proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques

Also Published As

Publication number Publication date
US20060292170A1 (en) 2006-12-28
JP2000517295A (ja) 2000-12-26
UY24654A1 (es) 2001-08-27
ZA976815B (en) 1998-05-11
PL331424A1 (en) 1999-07-19
NO319844B1 (no) 2005-09-19
CZ290826B6 (cs) 2002-10-16
BG63290B1 (bg) 2001-09-28
EP0957933A1 (en) 1999-11-24
WO1998005355A1 (en) 1998-02-12
NO990464L (no) 1999-02-01
GB9616351D0 (en) 1996-09-11
EA002167B1 (ru) 2002-02-28
DE69738672D1 (de) 2008-06-19
US20020172692A1 (en) 2002-11-21
NO990464D0 (no) 1999-02-01
KR20000029747A (ko) 2000-05-25
PL188741B1 (pl) 2005-04-29
PE97298A1 (es) 1999-02-14
BR9710913A (pt) 1999-08-17
ATE394119T1 (de) 2008-05-15
AU706303B2 (en) 1999-06-10
MY116128A (en) 2003-11-28
EP0957933B1 (en) 2008-05-07
OA10969A (en) 2003-03-04
BG103141A (en) 1999-08-31
AP1166A (en) 2003-06-30
DZ2283A1 (fr) 2002-12-25
AR008799A1 (es) 2000-02-23
IL128318A0 (en) 2000-01-31
CA2262402A1 (en) 1998-02-12
CZ29299A3 (cs) 1999-06-16
SK11599A3 (en) 2000-03-13
EP1623720A3 (en) 2006-02-22
ID17860A (id) 1998-01-29
UA68336C2 (en) 2004-08-16
CN1231613A (zh) 1999-10-13
MA24291A1 (fr) 1998-04-01
AP9901448A0 (en) 1999-03-31
SK282438B6 (sk) 2002-02-05
CN1241639C (zh) 2006-02-15
IL128318A (en) 2002-04-21
TR199900195T2 (xx) 1999-04-21
EP1623720A2 (en) 2006-02-08
CO4650186A1 (es) 1998-09-03
AU4204097A (en) 1998-02-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU