EA199800754A1 - Противопатогенные пептиды и композиции, их включающие - Google Patents
Противопатогенные пептиды и композиции, их включающиеInfo
- Publication number
- EA199800754A1 EA199800754A1 EA199800754A EA199800754A EA199800754A1 EA 199800754 A1 EA199800754 A1 EA 199800754A1 EA 199800754 A EA199800754 A EA 199800754A EA 199800754 A EA199800754 A EA 199800754A EA 199800754 A1 EA199800754 A1 EA 199800754A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- amino acid
- peptides
- possess
- acid residues
- hemolytic
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title 1
- 150000008574 D-amino acids Chemical group 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000001461 cytolytic effect Effects 0.000 abstract 2
- 230000002949 hemolytic effect Effects 0.000 abstract 2
- 150000008575 L-amino acids Chemical group 0.000 abstract 1
- 108010036176 Melitten Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010037075 Protozoal infections Diseases 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 abstract 1
- CTVQQQPWNOVEAG-QDOPKCMFSA-N pardaxin Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CN)C1=CC=CC=C1 CTVQQQPWNOVEAG-QDOPKCMFSA-N 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Insects & Arthropods (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11722396A IL117223A0 (en) | 1996-02-22 | 1996-02-22 | Antipathogenic polypeptides and compositions comprising them |
| PCT/IL1997/000066 WO1997031019A2 (en) | 1996-02-22 | 1997-02-20 | Antipathogenic peptides and compositions comprising them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA199800754A1 true EA199800754A1 (ru) | 1999-10-28 |
Family
ID=11068576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199800754A EA199800754A1 (ru) | 1996-02-22 | 1997-02-20 | Противопатогенные пептиды и композиции, их включающие |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6172038B1 (enExample) |
| EP (1) | EP0904291A2 (enExample) |
| JP (1) | JP2000506128A (enExample) |
| KR (2) | KR19990087100A (enExample) |
| CN (1) | CN1216549A (enExample) |
| AU (1) | AU730069B2 (enExample) |
| BR (1) | BR9707691A (enExample) |
| CA (1) | CA2247025A1 (enExample) |
| CZ (1) | CZ264398A3 (enExample) |
| EA (1) | EA199800754A1 (enExample) |
| IL (2) | IL117223A0 (enExample) |
| NZ (1) | NZ331219A (enExample) |
| WO (1) | WO1997031019A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9807456A (pt) * | 1997-02-20 | 2000-04-25 | Yeda Res & Dev | Peptìdios antipatogênicos sintéticos e composições que compreendem os mesmos |
| BR9912053A (pt) | 1998-07-13 | 2001-04-03 | Univ Texas | Processos de tratamento de câncer utilizando conjugados terapêuticos que se ligam a aminofosfolipìdios |
| US6818213B1 (en) | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| ATE348163T1 (de) | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| GB0005703D0 (en) | 2000-03-09 | 2000-05-03 | Alpharma As | Compounds |
| IL139720A0 (en) * | 2000-11-16 | 2002-02-10 | Yeda Res & Dev | Diastereomeric peptides and pharmaceutical compositions comprising them |
| US7671011B2 (en) * | 2003-06-19 | 2010-03-02 | Yeda Research & Development Co. Ltd. | Antimicrobial and anticancer lipopeptides |
| EP1773400A2 (en) | 2004-07-08 | 2007-04-18 | Amgen Inc. | Therapeutic peptides |
| CA2580796C (en) | 2004-09-24 | 2013-03-26 | Amgen Inc. | Modified fc molecules having peptides inserted in internal loop regions |
| CN101291683B (zh) * | 2004-11-24 | 2011-08-17 | 纽普罗研究有限公司 | 治疗疾病的方法和组合物 |
| WO2006128289A1 (en) * | 2005-06-02 | 2006-12-07 | University Of Manitoba | Use of brevinin-2r in the treatment of cancer |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| EP1973556A2 (en) * | 2005-12-27 | 2008-10-01 | Yeda Research And Development Co., Ltd. | Histidine-containing diastereomeric peptides and uses thereof |
| JP2009526046A (ja) | 2006-02-10 | 2009-07-16 | デルマゲン アクティエボラーグ | 新規分子 |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| WO2014038004A1 (ja) * | 2012-09-05 | 2014-03-13 | 株式会社メニコン | 薬物徐放性眼用レンズ及びその製造方法 |
| JP6093528B2 (ja) * | 2012-09-19 | 2017-03-08 | 株式会社ミルボン | スクリーニング方法 |
| WO2017134661A1 (en) | 2016-02-04 | 2017-08-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods for disrupting biofilms |
| GB2557654A (en) * | 2016-12-14 | 2018-06-27 | Uea Enterprises Ltd | Method for nucleic acid depletion |
| CN113528600A (zh) * | 2021-07-08 | 2021-10-22 | 石河子大学 | 一种利用沙门氏菌诱导蝇蛆制备抗菌肽的方法 |
| CN119607173B (zh) * | 2025-01-07 | 2026-05-26 | 天津医科大学朱宪彝纪念医院(天津医科大学代谢病医院、天津代谢病防治中心) | 小分子肽lklkll在制备降血糖产品中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258454A (en) * | 1988-09-01 | 1993-11-02 | Riso National Laboratory | Peptide synthesis method and solid support for use in the method |
-
1996
- 1996-02-22 IL IL11722396A patent/IL117223A0/xx unknown
-
1997
- 1997-02-20 KR KR1019980706488A patent/KR19990087100A/ko not_active Withdrawn
- 1997-02-20 AU AU17319/97A patent/AU730069B2/en not_active Ceased
- 1997-02-20 IL IL12573497A patent/IL125734A/xx not_active IP Right Cessation
- 1997-02-20 NZ NZ331219A patent/NZ331219A/xx unknown
- 1997-02-20 JP JP9529954A patent/JP2000506128A/ja not_active Ceased
- 1997-02-20 BR BR9707691A patent/BR9707691A/pt unknown
- 1997-02-20 CN CN97194000A patent/CN1216549A/zh active Pending
- 1997-02-20 CA CA002247025A patent/CA2247025A1/en not_active Abandoned
- 1997-02-20 CZ CZ982643A patent/CZ264398A3/cs unknown
- 1997-02-20 EA EA199800754A patent/EA199800754A1/ru unknown
- 1997-02-20 EP EP97904561A patent/EP0904291A2/en not_active Ceased
- 1997-02-20 US US09/125,605 patent/US6172038B1/en not_active Expired - Fee Related
- 1997-02-20 WO PCT/IL1997/000066 patent/WO1997031019A2/en not_active Ceased
-
1998
- 1998-02-19 KR KR1019997007477A patent/KR20000071187A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU730069B2 (en) | 2001-02-22 |
| EP0904291A2 (en) | 1999-03-31 |
| WO1997031019A3 (en) | 1997-10-23 |
| NZ331219A (en) | 2000-04-28 |
| CZ264398A3 (cs) | 1999-01-13 |
| JP2000506128A (ja) | 2000-05-23 |
| IL117223A0 (en) | 1996-06-18 |
| KR19990087100A (ko) | 1999-12-15 |
| CA2247025A1 (en) | 1997-08-28 |
| IL125734A (en) | 2005-08-31 |
| WO1997031019A2 (en) | 1997-08-28 |
| IL125734A0 (en) | 1999-04-11 |
| US6172038B1 (en) | 2001-01-09 |
| BR9707691A (pt) | 1999-07-27 |
| AU1731997A (en) | 1997-09-10 |
| CN1216549A (zh) | 1999-05-12 |
| KR20000071187A (ko) | 2000-11-25 |
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