EA038225B1 - Способ производства материала для регенерации кости, содержащего биоразлагаемое волокно, с использованием процесса электропрядения - Google Patents
Способ производства материала для регенерации кости, содержащего биоразлагаемое волокно, с использованием процесса электропрядения Download PDFInfo
- Publication number
- EA038225B1 EA038225B1 EA201890897A EA201890897A EA038225B1 EA 038225 B1 EA038225 B1 EA 038225B1 EA 201890897 A EA201890897 A EA 201890897A EA 201890897 A EA201890897 A EA 201890897A EA 038225 B1 EA038225 B1 EA 038225B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- kneader
- plga
- resin
- tcp
- plga resin
- Prior art date
Links
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 121
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- 230000011164 ossification Effects 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 229920001244 Poly(D,L-lactide) Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 229910052782 aluminium Inorganic materials 0.000 description 1
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- 230000024279 bone resorption Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
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- 229920006038 crystalline resin Polymers 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
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- 230000002950 deficient Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
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- 238000004388 gamma ray sterilization Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 229910000392 octacalcium phosphate Inorganic materials 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 229920000980 poly(hydroxybutyrate-co-hydroxyvalerate) Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
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- 238000000935 solvent evaporation Methods 0.000 description 1
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 1
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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Classifications
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L27/58—Materials at least partially resorbable by the body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
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- B29B7/84—Venting or degassing ; Removing liquids, e.g. by evaporating components
- B29B7/845—Venting, degassing or removing evaporated components in devices with rotary stirrers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
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- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- D01D5/0046—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by coagulation, i.e. wet electro-spinning
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- D—TEXTILES; PAPER
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- D—TEXTILES; PAPER
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- D01F1/00—General methods for the manufacture of artificial filaments or the like
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- D01F1/00—General methods for the manufacture of artificial filaments or the like
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- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
- D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
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- D—TEXTILES; PAPER
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- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
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- D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
- D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B13/00—Conditioning or physical treatment of the material to be shaped
- B29B2013/005—Degassing undesirable residual components, e.g. gases, unreacted monomers, from material to be moulded
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
- C08K2003/321—Phosphates
- C08K2003/325—Calcium, strontium or barium phosphate
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2331/00—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products
- D10B2331/04—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyesters, e.g. polyethylene terephthalate [PET]
- D10B2331/041—Fibres made from polymers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polycondensation products polyesters, e.g. polyethylene terephthalate [PET] derived from hydroxy-carboxylic acids, e.g. lactones
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2401/00—Physical properties
- D10B2401/12—Physical properties biodegradable
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/06—Vascular grafts; stents
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Textile Engineering (AREA)
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- Dermatology (AREA)
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- Cardiology (AREA)
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| JP7228848B2 (ja) * | 2018-02-22 | 2023-02-27 | 国立大学法人 名古屋工業大学 | エレクトロスピニング法を用いて製造した生分解性繊維材料を綿状に回収する方法、及びその方法を用いて製造された綿状の骨再生用材料 |
| CN109157678A (zh) * | 2018-08-31 | 2019-01-08 | 杭州卫达生物材料科技有限公司 | 一种骨填充材料及其制备方法 |
| JP7429391B2 (ja) * | 2018-11-02 | 2024-02-08 | 国立大学法人 名古屋工業大学 | 表面が親水化された生分解性繊維からなる骨再生用材料、及びその製造方法 |
| SG11202106161PA (en) * | 2018-12-25 | 2021-07-29 | Orthorebirth Co Ltd | A bone regeneration material having a cotton-wool like structure formed of a plurality of electrospun fibers |
| CN109594195B (zh) * | 2019-01-25 | 2021-11-05 | 蓝怡科技集团股份有限公司 | 一种棉花状纤维支架及其制备方法和用途 |
| JP2020130417A (ja) * | 2019-02-15 | 2020-08-31 | 学校法人明治大学 | 銀を担持させたβ相リン酸三カルシウム粒子を含有する生分解性繊維を含む骨再生用材料、及びその製造方法 |
| EP4168059A1 (en) * | 2020-06-21 | 2023-04-26 | Orthorebirth Co., Ltd. | Osteoinductive bone regeneration material and production method of the same |
| CN111910265A (zh) * | 2020-07-17 | 2020-11-10 | 湖南工程学院 | 一种带配液功能的静电纺丝注射装置 |
| CN112376168B (zh) * | 2020-11-13 | 2021-09-28 | 杭州高烯科技有限公司 | 一种无纺布的连续制备方法及系统 |
| CN112553785B (zh) * | 2020-11-16 | 2022-02-08 | 山东奥精生物科技有限公司 | 一种双层引导组织再生膜及其制备方法 |
| CN113373595B (zh) * | 2021-05-19 | 2023-02-03 | 济南大学 | 一种FeOOH/PVDF纤维支架及其制备方法和应用 |
| CN115821482B (zh) * | 2022-11-18 | 2024-06-25 | 江苏恒科新材料有限公司 | 一种阻燃隔热聚酯纳米复合纤维膜的制备方法 |
| CN115990289B (zh) * | 2023-01-09 | 2024-05-31 | 西岭(镇江)医疗科技有限公司 | 一种不完全脱钙骨诱导材料的制备方法 |
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| WO2016159240A1 (ja) * | 2015-03-31 | 2016-10-06 | Ｏｒｔｈｏｒｅｂｉｒｔｈ株式会社 | エレクトロスピニングを用いた、薬剤を含有する生分解性繊維素材の製造方法 |
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| US7541049B1 (en) * | 1997-09-02 | 2009-06-02 | Linvatec Biomaterials Oy | Bioactive and biodegradable composites of polymers and ceramics or glasses and method to manufacture such composites |
| CA2871840A1 (en) * | 2006-02-10 | 2007-08-23 | Tengion, Inc. | Scaffolds for organ reconstruction and augmentation |
| US20070255422A1 (en) * | 2006-04-25 | 2007-11-01 | Mei Wei | Calcium phosphate polymer composite and method |
| AU2006349544C1 (en) * | 2006-10-23 | 2013-11-28 | Eth Zurich | Implant material |
| EP2117616A2 (en) * | 2007-01-31 | 2009-11-18 | Technion Research & Development Foundation Ltd. | Electrospun scaffolds and methods of generating and using same |
| JP5179124B2 (ja) * | 2007-09-06 | 2013-04-10 | 矢橋工業株式会社 | 骨再生誘導膜、およびその製造方法 |
| ES2500616T3 (es) * | 2008-05-09 | 2014-09-30 | Evonik Corporation | Polímeros elastoméricos biocompatibles y biodegradables |
| US20110207859A1 (en) * | 2008-12-15 | 2011-08-25 | E.I.Du Pont De Nemours And Company | Copolyesters with enhanced tear strength |
| PL2243500T3 (pl) * | 2009-04-23 | 2012-06-29 | Purac Biochem Bv | Biozgodny kompozyt i jego zastosowanie |
| US8853298B2 (en) * | 2009-07-10 | 2014-10-07 | Nagoya Institute Of Technology | Fiber wadding for filling bone defects |
| US9194058B2 (en) * | 2011-01-31 | 2015-11-24 | Arsenal Medical, Inc. | Electrospinning process for manufacture of multi-layered structures |
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| JP2018057889A (ja) | 2018-04-12 |
| EP3381482A1 (en) | 2018-10-03 |
| EP3381482B1 (en) | 2023-11-22 |
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| CN108289975B (zh) | 2021-07-09 |
| AU2017257943A1 (en) | 2018-05-24 |
| WO2017188435A1 (ja) | 2017-11-02 |
| MY198692A (en) | 2023-09-16 |
| US20200289703A1 (en) | 2020-09-17 |
| JP6251462B1 (ja) | 2017-12-20 |
| UA123157C2 (uk) | 2021-02-24 |
| EP3381482C0 (en) | 2023-11-22 |
| KR102138040B1 (ko) | 2020-07-27 |
| JP6670870B2 (ja) | 2020-03-25 |
| KR20180084769A (ko) | 2018-07-25 |
| JPWO2017188435A1 (ja) | 2018-05-10 |
| AU2017257943B2 (en) | 2020-04-30 |
| US20180280569A1 (en) | 2018-10-04 |
| EP3381482A4 (en) | 2019-07-31 |
| CN108289975A (zh) | 2018-07-17 |
| US10646616B2 (en) | 2020-05-12 |
| US11969521B2 (en) | 2024-04-30 |
| US20240252714A1 (en) | 2024-08-01 |
| JP2018118063A (ja) | 2018-08-02 |
| EA201890897A1 (ru) | 2018-10-31 |
| JP6301001B1 (ja) | 2018-03-28 |
| ZA201802408B (en) | 2019-01-30 |
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