EA037561B1 - Способы лечения заболеваний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r) - Google Patents

Способы лечения заболеваний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r) Download PDF

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Publication number
EA037561B1
EA037561B1 EA201692482A EA201692482A EA037561B1 EA 037561 B1 EA037561 B1 EA 037561B1 EA 201692482 A EA201692482 A EA 201692482A EA 201692482 A EA201692482 A EA 201692482A EA 037561 B1 EA037561 B1 EA 037561B1
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EA
Eurasian Patent Office
Prior art keywords
antibody
weeks
csf1r
human
seq
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EA201692482A
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English (en)
Russian (ru)
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EA201692482A1 (ru
Inventor
Джули ХАМБЛТОН
Эмма Мастеллер
Джеймс Цзанхи
Роберт Сикорски
Хонг Сян
Original Assignee
Файв Прайм Терапьютикс, Инк.
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Application filed by Файв Прайм Терапьютикс, Инк. filed Critical Файв Прайм Терапьютикс, Инк.
Publication of EA201692482A1 publication Critical patent/EA201692482A1/ru
Publication of EA037561B1 publication Critical patent/EA037561B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
EA201692482A 2014-06-23 2015-06-18 Способы лечения заболеваний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r) EA037561B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462015710P 2014-06-23 2014-06-23
PCT/US2015/036419 WO2015200089A1 (en) 2014-06-23 2015-06-18 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)

Publications (2)

Publication Number Publication Date
EA201692482A1 EA201692482A1 (ru) 2017-05-31
EA037561B1 true EA037561B1 (ru) 2021-04-14

Family

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Family Applications (1)

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EA201692482A EA037561B1 (ru) 2014-06-23 2015-06-18 Способы лечения заболеваний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)

Country Status (13)

Country Link
US (2) US10975153B2 (enExample)
EP (1) EP3157957A1 (enExample)
JP (2) JP6964410B2 (enExample)
KR (2) KR20170016501A (enExample)
CN (2) CN106795222A (enExample)
AU (1) AU2015280362B2 (enExample)
BR (1) BR112016029460A2 (enExample)
CA (1) CA2951156A1 (enExample)
EA (1) EA037561B1 (enExample)
IL (1) IL249393B (enExample)
MX (1) MX391735B (enExample)
SG (2) SG11201610672YA (enExample)
WO (1) WO2015200089A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130302322A1 (en) 2012-05-11 2013-11-14 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
CA3058944A1 (en) * 2017-04-19 2018-10-25 Elstar Therapeutics, Inc. Multispecific molecules and uses thereof
CN109053887B (zh) * 2018-07-18 2019-07-23 博奥信生物技术(南京)有限公司 一种抗人csf-1r单克隆抗体及用途
CN108948199B (zh) * 2018-07-18 2019-06-21 博奥信生物技术(南京)有限公司 抗人csf-1r单克隆抗体及其用途
JP2021534101A (ja) 2018-08-09 2021-12-09 ヴェルソー セラピューティクス, インコーポレイテッド Ccr2及びcsf1rを標的とするためのオリゴヌクレオチド組成物ならびにその使用
US11419822B2 (en) * 2020-12-14 2022-08-23 AmMax Bio, Inc. High concentration formulations of anti-CSF1 and anti-CSF1R antibodies

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WO2013169264A1 (en) * 2012-05-11 2013-11-14 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
WO2014036357A1 (en) * 2012-08-31 2014-03-06 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)

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Also Published As

Publication number Publication date
KR20170016501A (ko) 2017-02-13
MX391735B (es) 2025-03-21
SG10201811475YA (en) 2019-02-27
US10975153B2 (en) 2021-04-13
IL249393B (en) 2022-02-01
AU2015280362A1 (en) 2016-12-22
JP2017520562A (ja) 2017-07-27
US20170152320A1 (en) 2017-06-01
JP6964410B2 (ja) 2021-11-10
BR112016029460A2 (pt) 2017-10-24
SG11201610672YA (en) 2017-01-27
CN113350501A (zh) 2021-09-07
KR20230086809A (ko) 2023-06-15
WO2015200089A1 (en) 2015-12-30
US20210317219A1 (en) 2021-10-14
EA201692482A1 (ru) 2017-05-31
CN106795222A (zh) 2017-05-31
CA2951156A1 (en) 2015-12-30
EP3157957A1 (en) 2017-04-26
MX2016016664A (es) 2017-03-20
JP2020169179A (ja) 2020-10-15
IL249393A0 (en) 2017-02-28
AU2015280362B2 (en) 2021-03-04

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