EA036591B1 - Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта - Google Patents

Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта Download PDF

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Publication number
EA036591B1
EA036591B1 EA201690080A EA201690080A EA036591B1 EA 036591 B1 EA036591 B1 EA 036591B1 EA 201690080 A EA201690080 A EA 201690080A EA 201690080 A EA201690080 A EA 201690080A EA 036591 B1 EA036591 B1 EA 036591B1
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EA
Eurasian Patent Office
Prior art keywords
sema4d
cancer
antibody
lymphocytes
tumor
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Application number
EA201690080A
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English (en)
Russian (ru)
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EA201690080A1 (ru
Inventor
Элизабет Э. Эванс
Эрнест С. Смит
Морис Заудерер
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Вэксинекс, Инк.
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Publication of EA201690080A1 publication Critical patent/EA201690080A1/ru
Publication of EA036591B1 publication Critical patent/EA036591B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations

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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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EA201690080A 2013-06-25 2014-06-20 Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта EA036591B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361839170P 2013-06-25 2013-06-25
US201361874241P 2013-09-05 2013-09-05
US201361884771P 2013-09-30 2013-09-30
US201361907845P 2013-11-22 2013-11-22
PCT/US2014/043466 WO2014209802A1 (en) 2013-06-25 2014-06-20 Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases

Publications (2)

Publication Number Publication Date
EA201690080A1 EA201690080A1 (ru) 2016-06-30
EA036591B1 true EA036591B1 (ru) 2020-11-26

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EA201690080A EA036591B1 (ru) 2013-06-25 2014-06-20 Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта

Country Status (18)

Country Link
US (6) US9243068B2 (enExample)
EP (2) EP3656392A1 (enExample)
JP (3) JP6611709B2 (enExample)
KR (2) KR102291971B1 (enExample)
CN (1) CN105492016B (enExample)
AU (2) AU2014302812B2 (enExample)
BR (1) BR112015032690B1 (enExample)
CA (2) CA3098741C (enExample)
DK (1) DK3013350T3 (enExample)
EA (1) EA036591B1 (enExample)
ES (1) ES2782834T3 (enExample)
IL (1) IL243301B (enExample)
MX (1) MX377858B (enExample)
NZ (1) NZ631015A (enExample)
PL (1) PL3013350T3 (enExample)
PT (1) PT3013350T (enExample)
SG (2) SG10201902380SA (enExample)
WO (1) WO2014209802A1 (enExample)

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WO2018071668A1 (en) 2016-10-12 2018-04-19 Board Of Regents, The University Of Texas System Methods and compositions for tusc2 immunotherapy
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JP7246320B2 (ja) 2017-05-05 2023-03-27 バクシネックス インコーポレーティッド ヒト抗セマフォリン４ｄ抗体
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WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
JP7568224B2 (ja) 2018-02-23 2024-10-16 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞療法のための配列決定法
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