EA036415B1 - Устойчивые к действию протеазы липидированные аналоги glp-1 - Google Patents
Устойчивые к действию протеазы липидированные аналоги glp-1 Download PDFInfo
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- EA036415B1 EA036415B1 EA201792640A EA201792640A EA036415B1 EA 036415 B1 EA036415 B1 EA 036415B1 EA 201792640 A EA201792640 A EA 201792640A EA 201792640 A EA201792640 A EA 201792640A EA 036415 B1 EA036415 B1 EA 036415B1
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| CA3025592A1 (en) * | 2016-06-09 | 2017-12-14 | Medimmune Limited | Protease-resistant mono-lipidated peptides |
| MX2020004497A (es) * | 2017-10-31 | 2020-08-13 | Medimmune Ltd | Administracion oral de analogos del peptido glp-1. |
| SI3774862T1 (sl) | 2018-04-05 | 2022-10-28 | Sun Pharmaceutical Industries Limited | Novi analogi GLP-1 |
| EP4281464A4 (en) | 2021-01-20 | 2025-01-01 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| IL311411A (en) | 2021-09-15 | 2024-05-01 | Viking Therapeutics Inc | Preparations and methods for the treatment of metabolic and liver disorders |
| TW202346323A (zh) * | 2022-02-07 | 2023-12-01 | 英商梅迪繆思有限公司 | 具有改善的生物穩定性的ｇｌｐ—１及升糖素雙重激動肽 |
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| WO2014088631A1 (en) * | 2012-12-06 | 2014-06-12 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
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| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
| EP1539210A4 (en) | 2002-09-06 | 2006-06-07 | Bayer Pharmaceuticals Corp | GLP-1 RECEPTOR MODIFIED AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE |
| CN101010339B (zh) * | 2004-07-02 | 2011-11-09 | 布里斯托尔-迈尔斯斯奎布公司 | 人类胰高血糖素样肽-1调节剂及它们在治疗糖尿病及相关病况中的用途 |
| CA2621699A1 (en) * | 2005-09-08 | 2007-03-15 | Trustees Of Tufts College | Stabilized glp-1 analogs |
| EP1854455B1 (en) * | 2006-05-10 | 2009-10-07 | Biocompatibles UK Limited | Spherical microcapsules comprising GLP-1 peptides, their production and use |
| US20100022457A1 (en) | 2006-05-26 | 2010-01-28 | Bristol-Myers Squibb Company | Sustained release glp-1 receptor modulators |
| WO2008023050A1 (en) | 2006-08-25 | 2008-02-28 | Novo Nordisk A/S | Acylated exendin-4 compounds |
| ES2422007T3 (es) | 2007-06-21 | 2013-09-06 | Univ Muenchen Tech | Proteínas activas biológicas que tienen estabilidad aumentada in vivo y/o in vitro |
| MX2010006287A (es) | 2007-12-11 | 2010-10-26 | Cadila Healthcare Ltd | Peptidomimeticos con actividades antagonistas de glucagon y agonistas del peptido 1 similar al glucagon. |
| JP5840498B2 (ja) * | 2008-12-05 | 2016-01-06 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | プロテアーゼ耐性ポリペプチドを選択するための方法 |
| CN102459325B (zh) | 2009-06-16 | 2015-03-25 | 印第安纳大学科技研究有限公司 | 胃抑胜肽受体活化的胰高血糖素化合物 |
| WO2011048614A2 (en) | 2009-10-22 | 2011-04-28 | Cadila Healthcare Limited | Short chain peptidomimetics based orally active glp-1 agonist and glucagon receptor antagonist |
| CA2797095A1 (en) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
| US20130143800A1 (en) | 2011-11-07 | 2013-06-06 | Research Development Foundation | Combination therapies to treat diabetes |
| EP2968581A1 (en) * | 2013-03-14 | 2016-01-20 | Medimmune Limited | Pegylated glucagon and glp-1 co-agonists for the treatment of obesity |
| MX2016007407A (es) | 2013-12-13 | 2016-12-12 | Medimmune Ltd | Peptidos resistentes a proteasa. |
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- 2016-06-09 EP EP20202888.2A patent/EP3865504A1/en not_active Withdrawn
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| WO2014049610A2 (en) * | 2012-09-26 | 2014-04-03 | Cadila Healthcare Limited | Peptides as gip, glp-1 and glucagon receptors triple-agonist |
| WO2014088631A1 (en) * | 2012-12-06 | 2014-06-12 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
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| HUI HONGXIANG , ZHAO XIAONING, PERFETTI RICCARDO: "Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes.", DIABETES/METABOLISM RESEARCH AND REVIEWS, WILEY, LONDON,, GB, vol. 21, no. 4, 1 July 2005 (2005-07-01), GB, pages 313 - 331, XP002559636, ISSN: 1520-7552, DOI: 10.1002/dmrr.553 * |
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| YOUN, Y.S. CHAE, S.Y. LEE, S. JEON, J.E. SHIN, H.G. LEE, K.C.: "Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 73, no. 1, 6 December 2006 (2006-12-06), US, pages 84 - 93, XP005794625, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2006.09.013 * |
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