EA036129B1 - Комбинированная терапия для лечения злокачественных новообразований - Google Patents

Комбинированная терапия для лечения злокачественных новообразований Download PDF

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Publication number
EA036129B1
EA036129B1 EA201890961A EA201890961A EA036129B1 EA 036129 B1 EA036129 B1 EA 036129B1 EA 201890961 A EA201890961 A EA 201890961A EA 201890961 A EA201890961 A EA 201890961A EA 036129 B1 EA036129 B1 EA 036129B1
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EA
Eurasian Patent Office
Prior art keywords
compound
day
azacytidine
dose
patient
Prior art date
Application number
EA201890961A
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English (en)
Russian (ru)
Other versions
EA201890961A1 (ru
Inventor
Вивек Сародж Кумар Чопра
Йорге Димартино
Лори А. Кенвин
Роберт Дуглас Найт
Кайл Макбет
Кришнан Висванадхан
Цян Сюй
Сэмюэл В. Агреста
Original Assignee
Селджин Корпорейшн
Аджиос Фармасьютикалз, Инк.
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Application filed by Селджин Корпорейшн, Аджиос Фармасьютикалз, Инк. filed Critical Селджин Корпорейшн
Publication of EA201890961A1 publication Critical patent/EA201890961A1/ru
Publication of EA036129B1 publication Critical patent/EA036129B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201890961A 2015-10-15 2016-10-14 Комбинированная терапия для лечения злокачественных новообразований EA036129B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562242218P 2015-10-15 2015-10-15
PCT/US2016/057102 WO2017066611A1 (en) 2015-10-15 2016-10-14 Combination therapy for treating malignancies

Publications (2)

Publication Number Publication Date
EA201890961A1 EA201890961A1 (ru) 2018-11-30
EA036129B1 true EA036129B1 (ru) 2020-10-01

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Family Applications (1)

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EA201890961A EA036129B1 (ru) 2015-10-15 2016-10-14 Комбинированная терапия для лечения злокачественных новообразований

Country Status (16)

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US (2) US10695352B2 (cg-RX-API-DMAC7.html)
EP (1) EP3362070B1 (cg-RX-API-DMAC7.html)
JP (1) JP6895956B2 (cg-RX-API-DMAC7.html)
KR (1) KR102701893B1 (cg-RX-API-DMAC7.html)
CN (1) CN108601787B (cg-RX-API-DMAC7.html)
AU (1) AU2016340098B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018007447B1 (cg-RX-API-DMAC7.html)
CA (1) CA3002029A1 (cg-RX-API-DMAC7.html)
CL (1) CL2018000955A1 (cg-RX-API-DMAC7.html)
EA (1) EA036129B1 (cg-RX-API-DMAC7.html)
ES (1) ES2862730T3 (cg-RX-API-DMAC7.html)
IL (1) IL258580B (cg-RX-API-DMAC7.html)
MX (1) MX381582B (cg-RX-API-DMAC7.html)
SG (2) SG11201802964QA (cg-RX-API-DMAC7.html)
WO (1) WO2017066611A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201802420B (cg-RX-API-DMAC7.html)

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WO2020092894A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol
US20220017489A1 (en) 2018-11-02 2022-01-20 Celgene Corporation Solid dispersions for treatment of cancer
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WO2020257665A1 (en) 2019-06-20 2020-12-24 Celgene Corporation Azacitidine in combination with venetoclax, gilteritinib, midostaurin or other compounds for treating leukemia or myelodysplastic syndrome
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WO2021097160A1 (en) 2019-11-14 2021-05-20 Celgene Corporation Pediatric formulations for treatment of cancer
CN111087408B (zh) * 2020-01-03 2021-04-02 浙江大学 一种大环结构的idh2突变体抑制剂及其医药用途
WO2022192621A1 (en) * 2021-03-12 2022-09-15 Celgene Corporation Methods for using a hypomethylating agent to treat diseases and disorders based on gene mutation profiles

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Also Published As

Publication number Publication date
AU2016340098B2 (en) 2022-06-02
EP3362070B1 (en) 2021-01-27
EA201890961A1 (ru) 2018-11-30
CN108601787A (zh) 2018-09-28
WO2017066611A1 (en) 2017-04-20
US20210100805A1 (en) 2021-04-08
SG10201912869WA (en) 2020-02-27
ES2862730T3 (es) 2021-10-07
BR112018007447A2 (en) 2018-10-23
JP2018535951A (ja) 2018-12-06
CL2018000955A1 (es) 2018-09-14
NZ741433A (en) 2024-07-26
JP6895956B2 (ja) 2021-06-30
EP3362070A1 (en) 2018-08-22
US20180303840A1 (en) 2018-10-25
CA3002029A1 (en) 2017-04-20
KR20180064529A (ko) 2018-06-14
MX2018004599A (es) 2018-09-21
IL258580B (en) 2021-05-31
ZA201802420B (en) 2020-08-26
BR112018007447B1 (pt) 2023-12-05
CN108601787B (zh) 2022-07-29
US10695352B2 (en) 2020-06-30
IL258580A (en) 2018-05-31
KR102701893B1 (ko) 2024-09-03
AU2016340098A1 (en) 2018-05-10
SG11201802964QA (en) 2018-05-30
MX381582B (es) 2025-03-12

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