EA035319B1 - СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ - Google Patents
СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ Download PDFInfo
- Publication number
- EA035319B1 EA035319B1 EA201690299A EA201690299A EA035319B1 EA 035319 B1 EA035319 B1 EA 035319B1 EA 201690299 A EA201690299 A EA 201690299A EA 201690299 A EA201690299 A EA 201690299A EA 035319 B1 EA035319 B1 EA 035319B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- region
- polypeptide
- antibody
- polypeptide according
- protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361860800P | 2013-07-31 | 2013-07-31 | |
| PCT/US2014/048908 WO2015017548A2 (en) | 2013-07-31 | 2014-07-30 | Stabilization of fc-containing polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201690299A1 EA201690299A1 (ru) | 2016-11-30 |
| EA035319B1 true EA035319B1 (ru) | 2020-05-27 |
Family
ID=52432568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690299A EA035319B1 (ru) | 2013-07-31 | 2014-07-30 | СТАБИЛИЗАЦИЯ Fc-СОДЕРЖАЩИХ ПОЛИПЕПТИДОВ |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20160193295A1 (OSRAM) |
| EP (1) | EP3027647A4 (OSRAM) |
| JP (2) | JP2016526909A (OSRAM) |
| KR (3) | KR20250152665A (OSRAM) |
| CN (1) | CN105658664A (OSRAM) |
| AU (3) | AU2014296215A1 (OSRAM) |
| BR (1) | BR112016002219A2 (OSRAM) |
| CA (1) | CA2919076C (OSRAM) |
| CL (1) | CL2016000232A1 (OSRAM) |
| EA (1) | EA035319B1 (OSRAM) |
| HK (1) | HK1224203A1 (OSRAM) |
| IL (1) | IL243690B (OSRAM) |
| MX (2) | MX2016001165A (OSRAM) |
| SG (1) | SG11201600734YA (OSRAM) |
| WO (1) | WO2015017548A2 (OSRAM) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013148117A1 (en) | 2012-03-27 | 2013-10-03 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| WO2014120619A2 (en) | 2013-01-30 | 2014-08-07 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
| FR3012453B1 (fr) | 2013-10-31 | 2015-11-13 | Lab Francais Du Fractionnement | Proteine chimerique dans le traitement de l’amylose |
| ES2883158T3 (es) | 2014-07-30 | 2021-12-07 | Ngm Biopharmaceuticals Inc | Composiciones y procedimientos de uso para el tratamiento de trastornos metabólicos |
| AP2017009828A0 (en) | 2014-10-31 | 2017-03-31 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders |
| CA2966776C (en) | 2014-12-19 | 2021-05-04 | Alkermes, Inc. | Single chain fc fusion proteins |
| IL294679B2 (en) | 2015-08-07 | 2023-10-01 | Alx Oncology Inc | Structures with a SIRP-alpha site or its variant |
| CA3025162A1 (en) | 2016-05-26 | 2017-11-30 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
| WO2018005226A2 (en) * | 2016-06-22 | 2018-01-04 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
| IL303806B2 (en) * | 2016-12-22 | 2024-05-01 | Cue Biopharma Inc | Multimeric polypeptides modulate T cells and methods for their use |
| US20190367611A1 (en) * | 2017-02-01 | 2019-12-05 | CentryMed Pharmaceutical Inc. | Monomeric human igg1 fc and bispecific antibodies |
| TWI832818B (zh) * | 2017-07-07 | 2024-02-21 | 南韓商韓美藥品股份有限公司 | 新穎的治療性酵素融合蛋白及其用途 |
| CN111182915A (zh) * | 2017-08-15 | 2020-05-19 | 金德雷德生物科学股份有限公司 | 兽药用IgG Fc变体 |
| CN107540748B (zh) * | 2017-09-15 | 2020-07-14 | 北京伟杰信生物科技有限公司 | 长效重组猪fsh融合蛋白及其制备方法与应用 |
| JP7403455B2 (ja) * | 2017-12-22 | 2023-12-22 | ハンミ ファーマシューティカル カンパニー リミテッド | 新規な構造を有する治療学的酵素融合タンパク質及びその用途 |
| TWI724392B (zh) | 2018-04-06 | 2021-04-11 | 美商美國禮來大藥廠 | 生長分化因子15促效劑化合物及其使用方法 |
| CN109021109A (zh) * | 2018-07-20 | 2018-12-18 | 上海交通大学 | 一种牛源性抗金黄色葡萄球菌融合抗体scFv-Fc及其制备方法 |
| MA53330A (fr) | 2018-08-03 | 2021-06-09 | Amgen Inc | Constructions d'anticorps pour cldn18.2 et cd3 |
| KR102200773B1 (ko) * | 2018-09-19 | 2021-01-12 | 주식회사 바이오앱 | 돼지의 Fc 단편과 융합된 항원 및 이를 포함하는 백신 조성물 |
| KR102148405B1 (ko) * | 2018-09-19 | 2020-08-27 | 주식회사 바이오앱 | 돼지의 Fc 단편을 포함하는 재조합 벡터 및 상기 벡터를 이용한 재조합 단백질의 제조 방법 |
| US10947278B2 (en) * | 2018-09-19 | 2021-03-16 | Bioapplications Inc. | Recombinant vector comprising porcine FC fragment and preparation method of recombinant protein using thereof |
| WO2020167957A1 (en) * | 2019-02-12 | 2020-08-20 | Board Of Regents, The University Of Texas System | High affinity engineered t-cell receptors targeting cmv infected cells |
| CN119700933A (zh) | 2019-05-31 | 2025-03-28 | Alx肿瘤生物技术公司 | 用SIRPαFc融合体组合免疫检查点抑制剂治疗癌症的方法 |
| CN114269784A (zh) | 2019-06-07 | 2022-04-01 | 美国安进公司 | 具有选择性可切割接头的双特异性结合构建体 |
| WO2021053556A1 (en) * | 2019-09-18 | 2021-03-25 | Novartis Ag | Nkg2d fusion proteins and uses thereof |
| JP7787812B2 (ja) | 2019-11-25 | 2025-12-17 | アルカームス インコーポレーテッド | 置換大環状化合物および関連する治療方法 |
| EP4071166A4 (en) * | 2019-12-11 | 2023-07-26 | Lg Chem, Ltd. | Fusion polypeptide comprising gdf15 and polypeptide region capable of o-glycosylation |
| WO2021150824A1 (en) | 2020-01-22 | 2021-07-29 | Amgen Research (Munich) Gmbh | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
| JP7481856B2 (ja) | 2020-02-25 | 2024-05-13 | シスメックス株式会社 | 改変抗体及びその製造方法、並びに抗体の熱安定性を向上させる方法 |
| CN111285936A (zh) * | 2020-03-11 | 2020-06-16 | 北京双赢科创生物科技有限公司 | 靶向肿瘤的酸性敏感纳米肽段及其应用 |
| US20230146593A1 (en) | 2020-03-12 | 2023-05-11 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecific antibodies binding to cds x cancer cell and tnf alpha or il-6 inhibitor |
| EP4153633A1 (en) | 2020-05-19 | 2023-03-29 | Amgen Inc. | Mageb2 binding constructs |
| WO2022032660A1 (zh) * | 2020-08-14 | 2022-02-17 | 武汉友微生物技术有限公司 | 新型冠状病毒rbd融合蛋白 |
| CN116194487A (zh) * | 2020-08-21 | 2023-05-30 | 亚洲大学校产学协力团 | 由重链恒定区和轻链恒定区组成的γ恒定区（Cγ1）和ε恒定区（Cε2-4）融合的抗体片段及其用途 |
| CN114426974B (zh) * | 2020-10-29 | 2023-11-21 | 洛阳普泰生物技术有限公司 | 特异性结合非洲猪瘟病毒CD2v蛋白的抗体或抗体片段 |
| WO2022094630A1 (en) * | 2020-11-02 | 2022-05-05 | Attralus, Inc. | Sap fc fusion proteins and methods of use |
| IL302586A (en) | 2020-11-06 | 2023-07-01 | Amgen Res Munich Gmbh | Polypeptide constructs selectively binding to cldn6 and cd3 |
| WO2022120286A1 (en) * | 2020-12-06 | 2022-06-09 | ALX Oncology Inc. | Multimers for reducing the interference of drugs that bind cd47 in serological assays |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| AU2022273727A1 (en) | 2021-05-13 | 2023-11-09 | ALX Oncology Inc. | Combination therapies for treating cancer |
| WO2023025129A1 (zh) * | 2021-08-24 | 2023-03-02 | 广东东阳光药业有限公司 | Gdf15融合蛋白及其用途 |
| CN116064562A (zh) * | 2022-10-28 | 2023-05-05 | 江南大学 | 玉米赤霉烯酮的真核表达单链抗体以及全长抗体的制备方法以及用途 |
| CN116284455B (zh) * | 2023-04-17 | 2024-10-11 | 北京康乐卫士生物技术股份有限公司 | 一种带状疱疹病毒疫苗的嵌合抗原及其应用 |
| WO2025036564A1 (de) * | 2023-08-17 | 2025-02-20 | Gottfried Wilhelm Leibniz Universität Hannover (Luh) | Nukleinsäuresequenz, vektor, screening-verfahren und verfahren zur herstellung von rekombinanten antikörpern |
| WO2025162460A1 (zh) * | 2024-02-04 | 2025-08-07 | 南通壹宸生物医药科技有限公司 | 一种轭合化合物及其制备和应用 |
| CN118344462B (zh) * | 2024-06-18 | 2024-11-08 | 苏州易合医药有限公司 | 一种用于肺部给药的索马鲁肽突变体、融合蛋白及相关产品 |
| CN119613573B (zh) * | 2025-02-14 | 2025-05-30 | 浙江大学 | 一种CD40L-Fc融合蛋白、基因片段、重组质粒、重组细胞以及制备方法和用途 |
| CN119735654B (zh) * | 2025-02-27 | 2025-07-01 | 浙江海隆生物科技股份有限公司 | 一种牛副流感病毒的亚单位hn蛋白制备方法和应用 |
| CN120623322B (zh) * | 2025-08-14 | 2025-12-05 | 成都蓉生药业有限责任公司 | 一种人IgG Fc变体、基因片段、表达载体、宿主细胞、IgG抗体及人IgG Fc变体制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070184523A1 (en) * | 1997-05-02 | 2007-08-09 | Genentech, Inc. | Method for Making Multispecific Antibodies Having Heteromultimeric and Common Components |
| US7754209B2 (en) * | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| US20120244578A1 (en) * | 2009-11-23 | 2012-09-27 | Amgen Inc. | Monomeric antibody fc |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU751659B2 (en) * | 1997-05-02 | 2002-08-22 | Genentech Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| US7951917B1 (en) * | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| JP2008511337A (ja) * | 2004-09-02 | 2008-04-17 | ジェネンテック・インコーポレーテッド | ヘテロ多量体分子 |
| KR101866623B1 (ko) * | 2005-11-28 | 2018-07-04 | 젠맵 에이/에스 | 재조합 １가 항체 및 그의 제조 방법 |
| PT2648752T (pt) * | 2010-12-06 | 2017-03-28 | Seattle Genetics Inc | Anticorpos humanizados a liv-1 e seu uso para tratar o cancro |
-
2014
- 2014-07-30 EP EP14832297.7A patent/EP3027647A4/en active Pending
- 2014-07-30 AU AU2014296215A patent/AU2014296215A1/en not_active Abandoned
- 2014-07-30 KR KR1020257032842A patent/KR20250152665A/ko active Pending
- 2014-07-30 CA CA2919076A patent/CA2919076C/en active Active
- 2014-07-30 EA EA201690299A patent/EA035319B1/ru not_active IP Right Cessation
- 2014-07-30 KR KR1020167004786A patent/KR20160034404A/ko not_active Ceased
- 2014-07-30 MX MX2016001165A patent/MX2016001165A/es unknown
- 2014-07-30 SG SG11201600734YA patent/SG11201600734YA/en unknown
- 2014-07-30 BR BR112016002219A patent/BR112016002219A2/pt not_active Application Discontinuation
- 2014-07-30 JP JP2016531860A patent/JP2016526909A/ja active Pending
- 2014-07-30 CN CN201480046222.5A patent/CN105658664A/zh active Pending
- 2014-07-30 KR KR1020237032656A patent/KR20230141929A/ko not_active Ceased
- 2014-07-30 HK HK16112553.6A patent/HK1224203A1/zh unknown
- 2014-07-30 US US14/909,431 patent/US20160193295A1/en not_active Abandoned
- 2014-07-30 IL IL243690A patent/IL243690B/en unknown
- 2014-07-30 WO PCT/US2014/048908 patent/WO2015017548A2/en not_active Ceased
-
2016
- 2016-01-27 MX MX2022008013A patent/MX2022008013A/es unknown
- 2016-01-28 CL CL2016000232A patent/CL2016000232A1/es unknown
-
2019
- 2019-03-08 US US16/297,494 patent/US20190192628A1/en active Pending
-
2020
- 2020-01-17 AU AU2020200329A patent/AU2020200329A1/en not_active Abandoned
- 2020-09-25 JP JP2020160475A patent/JP7344858B2/ja active Active
-
2022
- 2022-02-22 AU AU2022201204A patent/AU2022201204B2/en active Active
-
2025
- 2025-01-17 US US19/030,935 patent/US20250325631A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070184523A1 (en) * | 1997-05-02 | 2007-08-09 | Genentech, Inc. | Method for Making Multispecific Antibodies Having Heteromultimeric and Common Components |
| US7754209B2 (en) * | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| US20120244578A1 (en) * | 2009-11-23 | 2012-09-27 | Amgen Inc. | Monomeric antibody fc |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201690299A1 (ru) | 2016-11-30 |
| WO2015017548A2 (en) | 2015-02-05 |
| AU2022201204B2 (en) | 2025-01-02 |
| KR20250152665A (ko) | 2025-10-23 |
| CL2016000232A1 (es) | 2016-09-02 |
| CA2919076A1 (en) | 2015-02-05 |
| AU2020200329A1 (en) | 2020-02-06 |
| MX2022008013A (es) | 2022-07-27 |
| HK1224203A1 (zh) | 2017-08-18 |
| KR20160034404A (ko) | 2016-03-29 |
| US20160193295A1 (en) | 2016-07-07 |
| KR20230141929A (ko) | 2023-10-10 |
| EP3027647A2 (en) | 2016-06-08 |
| CA2919076C (en) | 2024-01-30 |
| CN105658664A (zh) | 2016-06-08 |
| AU2022201204A1 (en) | 2022-03-17 |
| SG11201600734YA (en) | 2016-02-26 |
| JP2016526909A (ja) | 2016-09-08 |
| MX2016001165A (es) | 2016-06-29 |
| WO2015017548A3 (en) | 2015-11-05 |
| JP7344858B2 (ja) | 2023-09-14 |
| IL243690A0 (en) | 2016-04-21 |
| US20190192628A1 (en) | 2019-06-27 |
| AU2014296215A1 (en) | 2016-02-11 |
| IL243690B (en) | 2022-09-01 |
| BR112016002219A2 (pt) | 2017-09-12 |
| US20250325631A1 (en) | 2025-10-23 |
| EP3027647A4 (en) | 2017-01-04 |
| JP2021019598A (ja) | 2021-02-18 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |