EA034577B1 - Материалы и способы, относящиеся к композициям стабилизированных полимерных силикатов - Google Patents
Материалы и способы, относящиеся к композициям стабилизированных полимерных силикатов Download PDFInfo
- Publication number
- EA034577B1 EA034577B1 EA201691441A EA201691441A EA034577B1 EA 034577 B1 EA034577 B1 EA 034577B1 EA 201691441 A EA201691441 A EA 201691441A EA 201691441 A EA201691441 A EA 201691441A EA 034577 B1 EA034577 B1 EA 034577B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- silicate
- composition
- stabilized polymer
- silicic acid
- compositions
- Prior art date
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| GB201402672A GB201402672D0 (en) | 2014-02-14 | 2014-02-14 | Materials and methods relating to stabilised polymeric silicate compositions |
| PCT/GB2015/050409 WO2015121666A1 (en) | 2014-02-14 | 2015-02-13 | Materials and methods relating to stabilised polymeric silicate compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201691441A1 EA201691441A1 (ru) | 2017-02-28 |
| EA034577B1 true EA034577B1 (ru) | 2020-02-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA201691441A EA034577B1 (ru) | 2014-02-14 | 2015-02-13 | Материалы и способы, относящиеся к композициям стабилизированных полимерных силикатов |
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|---|---|
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2652114T3 (es) | 2007-10-15 | 2018-01-31 | 7 Oaks Pharmaceutical Corporation | Una disolución que contiene silicato para uso en el tratamiento de melanoma |
| GB201507002D0 (en) * | 2015-04-24 | 2015-06-10 | Medical Res Council | Copper Oxo-hydroxide nanoparticles and their uses as biocidal agents |
| WO2017173317A1 (en) * | 2016-04-01 | 2017-10-05 | Nickels Daniel | Novel bone putty compositions and methods of use thereof |
| US10604257B2 (en) * | 2016-06-28 | 2020-03-31 | International Business Machines Corporation | Unmanned aerial vehicle for air sampling |
| JP7510254B2 (ja) * | 2016-08-10 | 2024-07-03 | ユナイテッド キングダム リサーチ アンド イノベーション | ナノシリカ粒子を含む組成物および療法のためにｔリンパ球を活性化する方法におけるそれらの使用 |
| KR20180034937A (ko) | 2016-09-28 | 2018-04-05 | 모멘티브퍼포먼스머티리얼스코리아 주식회사 | 유기 전자 소자 봉지재용 조성물 및 이를 이용하여 형성된 봉지재 |
| GB201701944D0 (en) * | 2017-02-06 | 2017-03-22 | Medical Res Council | Antimicrobial compositions and their uses |
| KR102427987B1 (ko) | 2018-11-27 | 2022-08-02 | 주식회사 엘지화학 | 전가수분해된 폴리실리케이트의 합성방법 |
| KR102207608B1 (ko) * | 2019-04-24 | 2021-01-26 | 윤종오 | 카르복실산으로 유기화된 규소 이온 복합체 및 복합체의 제조방법과 이를 이용한 제품 |
| WO2020218834A1 (ko) * | 2019-04-24 | 2020-10-29 | 윤종오 | 카르복실산으로 유기화된 규소 이온 복합체 및 복합체의 제조방법과 이를 이용한 제품 |
| US20230021329A1 (en) * | 2019-12-20 | 2023-01-26 | Veri Nano Inc. | Nanostructured binary gel composition and use thereof |
| SE2450523A1 (en) * | 2024-02-22 | 2025-08-23 | Lea Cares Ab | Method to form supernatant |
| WO2025178550A1 (en) * | 2024-02-22 | 2025-08-28 | Lea Cares Ab | Method to form supernatant |
| CN119660919A (zh) * | 2024-12-19 | 2025-03-21 | 河北清泓检测技术服务有限公司 | 一种适应高温高pH值的絮凝剂复配方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807951A (en) * | 1993-03-19 | 1998-09-15 | Nippon Zoki Pharmaceutical Co., Ltd. | Pharmaceutical composition regulating function of a living body |
| US20110229577A1 (en) * | 2008-08-01 | 2011-09-22 | Franz Kerek | Biologically active silicic acid |
| US20130130902A1 (en) * | 2010-03-31 | 2013-05-23 | Taminco | Stabilized bio-available soluble silicate solution |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1688228A (en) | 1928-10-16 | gebmany | ||
| US4029770A (en) | 1974-03-26 | 1977-06-14 | Caw Industries, Inc. | Method of therapeutically treating damaged and/or infected tissue and relieving stress and shock in warm blooded animals |
| US4563351A (en) | 1983-08-01 | 1986-01-07 | Forsyth Dental Infirmary For Children | Self-gelling therapeutic compositions for topical application |
| US5080900A (en) | 1990-04-17 | 1992-01-14 | Stanley R Thomas | Treatment of skin ulcers with an aqueous extract of oak bark ash |
| US7014870B1 (en) | 1992-11-06 | 2006-03-21 | Greystone Medical Group, Inc. | Compositions of oak bark extract related synthetic compositions and method of using same |
| DK0668769T3 (da) | 1992-11-06 | 2000-10-02 | Greystone Medical Group Inc | Egebarkekstrakt-relaterede syntetiske sammensætninger og fremgangsmåde til deres anvendelse |
| US5370876A (en) | 1993-01-08 | 1994-12-06 | Microbarriers | Antimicrobial protective skin composition and method for protecting skin from body fluids |
| NL9400189A (nl) | 1994-02-07 | 1995-09-01 | Bio Pharma Sciences Bv | Gestabiliseerd orthosiliciumzuur bevattend preparaat, een werkwijze voor het bereiden daarvan en een biologisch preparaat. |
| US20060246154A1 (en) | 1997-10-08 | 2006-11-02 | Hon David N | Composition of oak bark extract, related synthetic compositions, and method of using same |
| FR2799758B1 (fr) | 1999-10-15 | 2002-05-17 | Exsymol Sa | Complexe a base d'acide orthosilicique biologiquement assimilable, se presentant sous forme solide, stable et concentree, et procede de preparation |
| CA2298762C (en) | 2000-02-11 | 2001-06-12 | Paul M. Pidcock | Therapeutic compositions consisting of clarified multi-filtered soluable sodium silicate in liquid form are found to modify suppressor cells and enhanse the human immune system toprevent recurrence of herpes infections |
| KR100330993B1 (ko) | 2000-02-18 | 2002-04-01 | 김승일 | 액상 사료 첨가제 및 이의 제조방법 |
| RU2182006C2 (ru) | 2000-03-01 | 2002-05-10 | Цивинский Станислав Викторович | Способ лечения ревматоидного артрита |
| US6692775B2 (en) | 2000-03-13 | 2004-02-17 | Aqua Med, Inc. | Bactericidal gel and method for treating burns and dermal lesions |
| US6288045B1 (en) | 2000-06-09 | 2001-09-11 | Lifelink Pharmaceuticals, Inc. | Epithelial cell cancer drug |
| KR100331952B1 (ko) | 2000-11-23 | 2002-04-09 | 최수일 | 다목적 고기능성 알칼리 용액 조성물 및 그 제조방법과 비특이 면역증강제로서의 용도 |
| US20040057958A1 (en) | 2002-05-17 | 2004-03-25 | Waggoner David W. | Immunogenicity-enhancing carriers and compositions thereof and methods of using the same |
| UA80969C2 (en) | 2002-05-31 | 2007-11-26 | Aqueous solution of non-colloidal silicic and boric acids, method for its preparation and application | |
| US20040097467A1 (en) | 2002-08-22 | 2004-05-20 | Vijaya Juturu | Arginine silicate inositol complex and use thereof |
| RU2237483C1 (ru) | 2003-02-21 | 2004-10-10 | Цивинский Станислав Викторович | Средство для лечения гастрита с повышенной кислотностью и язвенной болезни и способ их лечения |
| US8187473B2 (en) | 2003-05-15 | 2012-05-29 | Kanumuru Rahul Raju | Functional transition metal silicates |
| CN100366534C (zh) * | 2004-05-09 | 2008-02-06 | 中国石化北京燕化石油化工股份有限公司 | 适用于阴离子聚合的层状硅酸盐的改性方法、由此得到的改性层状硅酸盐及其用途 |
| CN1315484C (zh) | 2004-11-16 | 2007-05-16 | 关相龙 | 治疗皮肤病的药物载体组合物及制备方法 |
| RU2280458C1 (ru) | 2004-11-30 | 2006-07-27 | Алевтина Ивановна Косолапова | Противовоспалительная мазь |
| DE102004063599B4 (de) | 2004-12-30 | 2007-07-12 | Bayer Innovation Gmbh | Verkürzte Wundheilungsprozesse mittels neuartiger Faservliese |
| NZ537747A (en) * | 2005-01-18 | 2008-02-29 | Victoria Link Ltd | Nano-structured silicate, functionalised forms thereof, preparation and uses |
| WO2006136003A1 (en) | 2005-04-20 | 2006-12-28 | Laboratoires Mauves Inc. | Organic silicic acids complex for therapeutic and cosmetic applications |
| US20070161539A1 (en) * | 2006-01-12 | 2007-07-12 | Enrique Hernandez | Method of regulating degree of polymerization of an alkali metal silicate in solution using pH |
| WO2008147468A2 (en) | 2006-12-18 | 2008-12-04 | Amcol International | Compositions comprising virus-interacting layered phyllosilicates and a therapeutic agent, and methods of use |
| US20100278935A1 (en) | 2007-07-30 | 2010-11-04 | Stacey William C | Immune System Modulator Formulation |
| ES2652114T3 (es) | 2007-10-15 | 2018-01-31 | 7 Oaks Pharmaceutical Corporation | Una disolución que contiene silicato para uso en el tratamiento de melanoma |
| US20110009486A1 (en) | 2008-03-03 | 2011-01-13 | Luna Innovations Incorporated | Method for treating pruritus by administering fullerenes |
| WO2009127256A1 (en) * | 2008-04-17 | 2009-10-22 | Jisbrey, S.A | Hydronium stabilized and dissoluble silicic acid nanoparticles: preparation, stabilization and use |
| US9345720B2 (en) * | 2010-10-26 | 2016-05-24 | Exeltis Usa Dermatology, Inc. | Composition and method for treating wounds |
| GB201402669D0 (en) * | 2014-02-14 | 2014-04-02 | Medical Res Council | Stabilised silicate compositions and their uses |
-
2014
- 2014-02-14 GB GB201402672A patent/GB201402672D0/en not_active Ceased
-
2015
- 2015-02-13 KR KR1020167024827A patent/KR102354909B1/ko active Active
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- 2015-02-13 SG SG10202000307VA patent/SG10202000307VA/en unknown
- 2015-02-13 EA EA201691441A patent/EA034577B1/ru unknown
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807951A (en) * | 1993-03-19 | 1998-09-15 | Nippon Zoki Pharmaceutical Co., Ltd. | Pharmaceutical composition regulating function of a living body |
| US20110229577A1 (en) * | 2008-08-01 | 2011-09-22 | Franz Kerek | Biologically active silicic acid |
| US20130130902A1 (en) * | 2010-03-31 | 2013-05-23 | Taminco | Stabilized bio-available soluble silicate solution |
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| GB201402672D0 (en) | 2014-04-02 |
| US20190224233A1 (en) | 2019-07-25 |
| CA2939419C (en) | 2022-07-26 |
| EP3105281A1 (en) | 2016-12-21 |
| AU2015216711A1 (en) | 2016-09-22 |
| CN106164136B (zh) | 2019-11-08 |
| US20240066053A1 (en) | 2024-02-29 |
| HK1226424A1 (zh) | 2017-09-29 |
| SG10202007920RA (en) | 2020-10-29 |
| WO2015121666A1 (en) | 2015-08-20 |
| KR102354909B1 (ko) | 2022-01-24 |
| KR20160124797A (ko) | 2016-10-28 |
| JP6618475B2 (ja) | 2019-12-11 |
| CN106164136A (zh) | 2016-11-23 |
| EP3105281B1 (en) | 2021-04-21 |
| NZ723746A (en) | 2022-09-30 |
| SG10202000307VA (en) | 2020-03-30 |
| AU2015216711B2 (en) | 2018-08-09 |
| EA201691441A1 (ru) | 2017-02-28 |
| ES2872498T3 (es) | 2021-11-02 |
| US10898511B2 (en) | 2021-01-26 |
| JP2017512189A (ja) | 2017-05-18 |
| US11833171B2 (en) | 2023-12-05 |
| CA2939419A1 (en) | 2015-08-20 |
| US20210145866A1 (en) | 2021-05-20 |
| US20170042934A1 (en) | 2017-02-16 |
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