EA032975B1 - Фармацевтическая композиция, содержащая циклический пептид формулы x1-gqretpegaeakpwy-x2, и применение для экстракорпоральной обработки легких - Google Patents
Фармацевтическая композиция, содержащая циклический пептид формулы x1-gqretpegaeakpwy-x2, и применение для экстракорпоральной обработки легкихInfo
- Publication number
- EA032975B1 EA032975B1 EA201592018A EA201592018A EA032975B1 EA 032975 B1 EA032975 B1 EA 032975B1 EA 201592018 A EA201592018 A EA 201592018A EA 201592018 A EA201592018 A EA 201592018A EA 032975 B1 EA032975 B1 EA 032975B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- formula
- gqretpegaeakpwy
- pharmaceutical composition
- xand
- cyclic peptide
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
Abstract
Изобретение относится к способу экстракорпорального кондиционирования/улучшения функций легких посредством обработки легкого ex vivo циклическим соединением аминокислотной последовательности формулы IX-GQRETPEGAEAKPWY-X,где Xвключает аминокислоту (последовательность) с 1 до 4 членов, включая природные или неприродные аминокислоты, и Xвключает одну аминокислоту, выбранную из природных аминокислот; и к фармацевтической композиции, содержащей пептид формулы I, как определено в любом из пп.1-7, в форме, которая является подходящей для распыления, чтобы получить аэрозоль для ингаляции, или которая подходит для получения спрея, чтобы получить аэрозоль при распылении, который является подходящим для ингаляции.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13164828 | 2013-04-23 | ||
PCT/EP2014/058012 WO2014173843A1 (en) | 2013-04-23 | 2014-04-18 | Pharmaceutical composition comprising a cyclic peptide of formula x1 -gqretpegaeakpwy-x2 and use for extracorporeal lung treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201592018A1 EA201592018A1 (ru) | 2016-03-31 |
EA032975B1 true EA032975B1 (ru) | 2019-08-30 |
Family
ID=48143175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201592018A EA032975B1 (ru) | 2013-04-23 | 2014-04-18 | Фармацевтическая композиция, содержащая циклический пептид формулы x1-gqretpegaeakpwy-x2, и применение для экстракорпоральной обработки легких |
Country Status (11)
Country | Link |
---|---|
US (1) | US20160143266A1 (ru) |
EP (1) | EP2988769B1 (ru) |
JP (1) | JP6335279B2 (ru) |
KR (1) | KR102113501B1 (ru) |
CN (1) | CN105188735A (ru) |
AU (1) | AU2014257679A1 (ru) |
CA (1) | CA2908560C (ru) |
EA (1) | EA032975B1 (ru) |
ES (1) | ES2813379T3 (ru) |
IL (1) | IL242074B (ru) |
WO (1) | WO2014173843A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US12004506B2 (en) | 2013-04-23 | 2024-06-11 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment |
ES2805698T3 (es) * | 2015-09-14 | 2021-02-15 | Apeptico Forschung & Entwicklung Gmbh | Polipéptido cíclico para el tratamiento de PHA tipo 1B |
JP7100971B2 (ja) | 2017-11-20 | 2022-07-14 | ファナック株式会社 | 電流検出器を有するモータ駆動装置 |
US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006013183A1 (en) * | 2004-08-06 | 2006-02-09 | Altana Pharma Ag | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
WO2010099556A1 (de) * | 2009-03-05 | 2010-09-10 | Apeptico Forschung Und Entwicklung Gmbh | Verfahren zur vermeidung und zur behandlung einer hyperpermeabilität |
WO2011085423A1 (de) * | 2010-01-14 | 2011-07-21 | Apeptico Forschung Und Entwicklung Gmbh | Zyklische peptide zur regulierung von vektoriellen ionenkanälen |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE374039T1 (de) * | 1998-08-14 | 2007-10-15 | Rudolf Lucas | Tnf-peptide und deren verwendung zur behandlung von ödemen |
AT510585B1 (de) * | 2010-11-18 | 2012-05-15 | Apeptico Forschung & Entwicklung Gmbh | Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase |
-
2014
- 2014-04-18 EA EA201592018A patent/EA032975B1/ru not_active IP Right Cessation
- 2014-04-18 JP JP2016509416A patent/JP6335279B2/ja active Active
- 2014-04-18 AU AU2014257679A patent/AU2014257679A1/en not_active Abandoned
- 2014-04-18 CA CA2908560A patent/CA2908560C/en active Active
- 2014-04-18 US US14/784,903 patent/US20160143266A1/en not_active Abandoned
- 2014-04-18 KR KR1020157030438A patent/KR102113501B1/ko active IP Right Grant
- 2014-04-18 ES ES14721803T patent/ES2813379T3/es active Active
- 2014-04-18 CN CN201480023416.3A patent/CN105188735A/zh active Pending
- 2014-04-18 WO PCT/EP2014/058012 patent/WO2014173843A1/en active Application Filing
- 2014-04-18 EP EP14721803.6A patent/EP2988769B1/en active Active
-
2015
- 2015-10-14 IL IL242074A patent/IL242074B/en active IP Right Grant
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006013183A1 (en) * | 2004-08-06 | 2006-02-09 | Altana Pharma Ag | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
WO2010099556A1 (de) * | 2009-03-05 | 2010-09-10 | Apeptico Forschung Und Entwicklung Gmbh | Verfahren zur vermeidung und zur behandlung einer hyperpermeabilität |
WO2011085423A1 (de) * | 2010-01-14 | 2011-07-21 | Apeptico Forschung Und Entwicklung Gmbh | Zyklische peptide zur regulierung von vektoriellen ionenkanälen |
Non-Patent Citations (3)
Title |
---|
ELIA NADIA, ET AL: "Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE., AMERICAN LUNG ASSOCIATION, NEW YORK, NY., US, vol. 168, no. 9, 1 November 2003 (2003-11-01), US, pages 1043 - 1050, XP002455314, ISSN: 1073-449X, DOI: 10.1164/rccm.200206-618OC * |
PARASTOO HAZEMI, SUSAN J. TZOTZOS, BERNHARD FISCHER, GOWRI SHANKAR BAGAVANANTHEM ANDAVAN, HENDRIK FISCHER, HELMUT PIETSCHMANN, RUD: "Essential structural features of TNF-alpha lectin-like domain derived peptides for activation of amiloride-sensitive sodium currecnt in A549 cells", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 53, no. 22, 27 October 2010 (2010-10-27), American Chemical Society, pages 8021 - 8029, XP002638326, DOI: 10.1021/jm100767p * |
VADASZ I; SCHERMULY R T; GHOFRANI H A; RUMMEL S; WEHNER S; MUHLDORFER I; SCHAFER K P; SEEGER W; MORTY R E; GRIMMINGER F; WEISSMANN: "The lectin-like domain of tumor necrosis factor-[alpha] improves alveolar fluid balance in injured isolated rabbit lungs", CRITICAL CARE MEDICINE., LIPPINCOTT WILLIAMS & WILKINS, US, vol. 36, no. 5, 1 May 2008 (2008-05-01), US, pages 1543 - 1550, XP009172075, ISSN: 0090-3493, DOI: 10.1097/CCM.0b013e31816f485e * |
Also Published As
Publication number | Publication date |
---|---|
EP2988769B1 (en) | 2020-05-27 |
ES2813379T3 (es) | 2021-03-23 |
US20160143266A1 (en) | 2016-05-26 |
EA201592018A1 (ru) | 2016-03-31 |
CA2908560C (en) | 2021-03-09 |
CN105188735A (zh) | 2015-12-23 |
AU2014257679A1 (en) | 2015-10-15 |
JP6335279B2 (ja) | 2018-05-30 |
KR102113501B1 (ko) | 2020-05-22 |
JP2016518377A (ja) | 2016-06-23 |
WO2014173843A1 (en) | 2014-10-30 |
KR20150144757A (ko) | 2015-12-28 |
EP2988769A1 (en) | 2016-03-02 |
CA2908560A1 (en) | 2014-10-30 |
IL242074B (en) | 2019-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |