EA027984B1 - Аминохинолины в качестве ингибиторов rip2 киназы - Google Patents
Аминохинолины в качестве ингибиторов rip2 киназы Download PDFInfo
- Publication number
- EA027984B1 EA027984B1 EA201590552A EA201590552A EA027984B1 EA 027984 B1 EA027984 B1 EA 027984B1 EA 201590552 A EA201590552 A EA 201590552A EA 201590552 A EA201590552 A EA 201590552A EA 027984 B1 EA027984 B1 EA 027984B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tert
- butylsulfonyl
- dimethyl
- pyrazol
- mmol
- Prior art date
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Landscapes
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- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201261700536P | 2012-09-13 | 2012-09-13 | |
| US201361767378P | 2013-02-21 | 2013-02-21 | |
| PCT/US2013/059600 WO2014043437A1 (en) | 2012-09-13 | 2013-09-13 | Amino-quinolines as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
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| EA201590552A1 EA201590552A1 (ru) | 2015-06-30 |
| EA027984B1 true EA027984B1 (ru) | 2017-09-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| EA201590552A EA027984B1 (ru) | 2012-09-13 | 2013-09-13 | Аминохинолины в качестве ингибиторов rip2 киназы |
Country Status (21)
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| US (1) | US9216965B2 (enExample) |
| EP (1) | EP2895167B1 (enExample) |
| JP (1) | JP6258331B2 (enExample) |
| KR (1) | KR20150053920A (enExample) |
| CN (1) | CN104602692B (enExample) |
| AR (1) | AR092530A1 (enExample) |
| AU (1) | AU2013315387B2 (enExample) |
| BR (1) | BR112015004967A2 (enExample) |
| CA (1) | CA2883155A1 (enExample) |
| CL (1) | CL2015000615A1 (enExample) |
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| IL (1) | IL237158A0 (enExample) |
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| TW (1) | TW201425307A (enExample) |
| WO (1) | WO2014043437A1 (enExample) |
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| UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| SG192769A1 (en) | 2011-03-04 | 2013-09-30 | Glaxosmithkline Ip No 2 Ltd | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
| AR092530A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| JP6301374B2 (ja) | 2013-02-21 | 2018-03-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | キナーゼ阻害剤としてのキナゾリン類 |
| GB201506872D0 (en) * | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| GB201516243D0 (en) | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| MX2018004109A (es) | 2015-10-05 | 2018-09-27 | Univ Columbia | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. |
| CN107158385B (zh) * | 2016-03-14 | 2020-07-14 | 苏州大学 | Rip3抑制剂在制备抗血小板血栓药物中的用途 |
| CN109311867A (zh) | 2016-04-20 | 2019-02-05 | 葛兰素史克知识产权开发有限公司 | 包含ripk2抑制剂的共轭物 |
| WO2020094613A1 (en) | 2018-11-06 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nod2 inhibitors for the treatment of hereditary periodic fevers |
| CN114014890A (zh) * | 2021-03-12 | 2022-02-08 | 爱科诺生物医药(香港)有限公司 | 具有rip2激酶抑制活性的化合物，包含其的药物组合物，及其应用 |
| WO2025078493A1 (en) | 2023-10-11 | 2025-04-17 | Institut National de la Santé et de la Recherche Médicale | Local administration of ripk2 inhibitors for the curative treatment of allergic asthma |
Citations (3)
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| US20030212276A1 (en) * | 2002-04-30 | 2003-11-13 | Wyeth Holdings Corporation | Process for the preparation of 7-substituted-3 quinolinecarbonitriles |
| US20120041024A1 (en) * | 2010-08-10 | 2012-02-16 | Adam Kenneth Charnley | Quinolyl amines as kinase inhibitors |
| US20120219522A1 (en) * | 2011-02-28 | 2012-08-30 | Dr. Ning XI | Substituted quinoline compounds and methods of use |
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| US20130005726A1 (en) | 2010-03-08 | 2013-01-03 | Derek Abbott | Compositions and methods for treating inflammatory disorders |
| WO2011120026A1 (en) | 2010-03-26 | 2011-09-29 | Glaxo Group Limited | Pyrazolyl-pyrimidines as kinase inhibitors |
| EP2552211A4 (en) | 2010-03-26 | 2013-10-23 | Glaxo Group Ltd | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER |
| US20130018039A1 (en) | 2010-03-31 | 2013-01-17 | Bodmer Vera Q | Imidazolyl-imidazoles as kinase inhibitors |
| WO2011140442A1 (en) | 2010-05-07 | 2011-11-10 | Glaxo Group Limited | Amino-quinolines as kinase inhibitors |
| WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| SG192769A1 (en) * | 2011-03-04 | 2013-09-30 | Glaxosmithkline Ip No 2 Ltd | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) * | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| AR092530A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
| JP6301374B2 (ja) | 2013-02-21 | 2018-03-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | キナーゼ阻害剤としてのキナゾリン類 |
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2013
- 2013-09-11 AR ARP130103248A patent/AR092530A1/es unknown
- 2013-09-11 TW TW102132714A patent/TW201425307A/zh unknown
- 2013-09-13 EA EA201590552A patent/EA027984B1/ru not_active IP Right Cessation
- 2013-09-13 WO PCT/US2013/059600 patent/WO2014043437A1/en not_active Ceased
- 2013-09-13 ES ES13836616T patent/ES2713172T3/es active Active
- 2013-09-13 EP EP13836616.6A patent/EP2895167B1/en active Active
- 2013-09-13 US US14/396,559 patent/US9216965B2/en not_active Expired - Fee Related
- 2013-09-13 MX MX2015003275A patent/MX2015003275A/es unknown
- 2013-09-13 CA CA2883155A patent/CA2883155A1/en not_active Abandoned
- 2013-09-13 AU AU2013315387A patent/AU2013315387B2/en not_active Ceased
- 2013-09-13 KR KR1020157006177A patent/KR20150053920A/ko not_active Withdrawn
- 2013-09-13 BR BR112015004967A patent/BR112015004967A2/pt active Search and Examination
- 2013-09-13 CN CN201380045559.XA patent/CN104602692B/zh not_active Expired - Fee Related
- 2013-09-13 PE PE2015000276A patent/PE20150774A1/es not_active Application Discontinuation
- 2013-09-13 SG SG11201500973WA patent/SG11201500973WA/en unknown
- 2013-09-13 JP JP2015532064A patent/JP6258331B2/ja not_active Expired - Fee Related
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2015
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- 2015-02-17 PH PH12015500345A patent/PH12015500345A1/en unknown
- 2015-03-12 CL CL2015000615A patent/CL2015000615A1/es unknown
- 2015-03-13 CR CR20150133A patent/CR20150133A/es unknown
- 2015-03-13 DO DO2015000059A patent/DOP2015000059A/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030212276A1 (en) * | 2002-04-30 | 2003-11-13 | Wyeth Holdings Corporation | Process for the preparation of 7-substituted-3 quinolinecarbonitriles |
| US20120041024A1 (en) * | 2010-08-10 | 2012-02-16 | Adam Kenneth Charnley | Quinolyl amines as kinase inhibitors |
| US20120219522A1 (en) * | 2011-02-28 | 2012-08-30 | Dr. Ning XI | Substituted quinoline compounds and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| PH12015500345A1 (en) | 2015-04-20 |
| BR112015004967A2 (pt) | 2020-04-22 |
| MX2015003275A (es) | 2015-07-06 |
| EP2895167A4 (en) | 2016-03-16 |
| CA2883155A1 (en) | 2014-03-20 |
| US20150094333A1 (en) | 2015-04-02 |
| CN104602692B (zh) | 2017-06-23 |
| AR092530A1 (es) | 2015-04-22 |
| EP2895167A1 (en) | 2015-07-22 |
| TW201425307A (zh) | 2014-07-01 |
| JP6258331B2 (ja) | 2018-01-10 |
| AU2013315387A1 (en) | 2015-02-26 |
| CL2015000615A1 (es) | 2015-08-28 |
| JP2015528508A (ja) | 2015-09-28 |
| SG11201500973WA (en) | 2015-04-29 |
| EP2895167B1 (en) | 2018-12-05 |
| US9216965B2 (en) | 2015-12-22 |
| DOP2015000059A (es) | 2015-05-15 |
| WO2014043437A1 (en) | 2014-03-20 |
| ES2713172T3 (es) | 2019-05-20 |
| KR20150053920A (ko) | 2015-05-19 |
| IL237158A0 (en) | 2015-04-30 |
| CN104602692A (zh) | 2015-05-06 |
| PE20150774A1 (es) | 2015-05-28 |
| EA201590552A1 (ru) | 2015-06-30 |
| CR20150133A (es) | 2015-05-04 |
| AU2013315387B2 (en) | 2016-09-08 |
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