EA027030B1 - Способ и система для введения легочного сурфактанта путем атомизации - Google Patents
Способ и система для введения легочного сурфактанта путем атомизации Download PDFInfo
- Publication number
- EA027030B1 EA027030B1 EA201491812A EA201491812A EA027030B1 EA 027030 B1 EA027030 B1 EA 027030B1 EA 201491812 A EA201491812 A EA 201491812A EA 201491812 A EA201491812 A EA 201491812A EA 027030 B1 EA027030 B1 EA 027030B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- channel
- catheter
- patient
- surfactant
- drug
- Prior art date
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- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M25/003—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Percussion Or Vibration Massage (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12165234 | 2012-04-23 | ||
| PCT/EP2013/057744 WO2013160129A1 (en) | 2012-04-23 | 2013-04-12 | Method and system for the administration of a pulmonary surfactant by atomization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491812A1 EA201491812A1 (ru) | 2015-02-27 |
| EA027030B1 true EA027030B1 (ru) | 2017-06-30 |
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Family Applications (1)
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| EA201491812A EA027030B1 (ru) | 2012-04-23 | 2013-04-12 | Способ и система для введения легочного сурфактанта путем атомизации |
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| EP (1) | EP2841135B1 (enExample) |
| JP (1) | JP6293732B2 (enExample) |
| KR (1) | KR102051677B1 (enExample) |
| CN (1) | CN104321103B (enExample) |
| AR (1) | AR090811A1 (enExample) |
| AU (1) | AU2013251865B2 (enExample) |
| BR (1) | BR112014026212A8 (enExample) |
| CA (1) | CA2870391A1 (enExample) |
| CL (1) | CL2014002863A1 (enExample) |
| CO (1) | CO7160044A2 (enExample) |
| EA (1) | EA027030B1 (enExample) |
| ES (1) | ES2616082T3 (enExample) |
| IL (1) | IL235143A0 (enExample) |
| IN (1) | IN2014DN09602A (enExample) |
| MA (1) | MA37431B1 (enExample) |
| MX (1) | MX351677B (enExample) |
| NZ (1) | NZ701073A (enExample) |
| PE (1) | PE20150604A1 (enExample) |
| PH (1) | PH12014502321A1 (enExample) |
| SG (1) | SG11201406628RA (enExample) |
| TN (1) | TN2014000429A1 (enExample) |
| WO (1) | WO2013160129A1 (enExample) |
| ZA (1) | ZA201407557B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201609206A (zh) * | 2013-10-22 | 2016-03-16 | 奇希製藥公司 | 藉由霧化投予肺部表面活性劑之改良方法及系統 |
| WO2016089981A1 (en) * | 2014-12-04 | 2016-06-09 | Carefusion 2200, Inc. | Breath-actuated nebulizer for medicine inhalation |
| WO2016109390A1 (en) | 2014-12-29 | 2016-07-07 | Ony Inc. | Aerosol medication delivery system and method |
| ES2901761T3 (es) | 2015-01-13 | 2022-03-23 | Trudell Medical Int | Interfaz respiratoria |
| EP3106090A1 (en) | 2015-06-15 | 2016-12-21 | CHIESI FARMACEUTICI S.p.A. | System for effective breath-synchronized delivery of medicament to the lungs |
| CN107666933A (zh) * | 2015-04-22 | 2018-02-06 | 奇斯药制品公司 | 用于药物有效地呼吸同步递送到肺部的方法和系统 |
| WO2016174098A1 (en) * | 2015-04-28 | 2016-11-03 | Chiesi Farmaceutici S.P.A. | Device for facilitating the administration of a medicament to the lung by a catheter |
| WO2016173634A1 (en) | 2015-04-28 | 2016-11-03 | Chiesi Farmaceutici S.P.A | Device for facilitating the administration of a medicament to the lung by a catheter |
| WO2017086939A1 (en) * | 2015-11-17 | 2017-05-26 | Flosure Technologies Llc | Tracheal or endotracheal device having an integrated system for removing infectious secretions |
| EP3407844A4 (en) * | 2016-01-29 | 2019-10-16 | Qool Therapeutics, Inc. | AEROSOLISATION OF STEM CELLS OR STEM CELL DERIVATIVES FOR PULMONARY ADMINISTRATION |
| KR101861078B1 (ko) * | 2016-03-29 | 2018-05-28 | (주)엘메카 | 네트워크를 통한 의료용 석션기의 관리 방법 및 이에 사용되는 관리 서버 |
| WO2018019719A1 (en) | 2016-07-28 | 2018-02-01 | Chiesi Farmaceutici S.P.A | Method and system for delivery of an aerosolized medicament |
| ES2892903T3 (es) * | 2016-10-26 | 2022-02-07 | Chiesi Farm Spa | Dispositivo para facilitar la administración de un medicamento a los pulmones por medio de un catéter |
| AU2018240522B2 (en) * | 2017-03-23 | 2023-07-06 | Stamford Devices Ltd | Aerosol delivery system and method |
| US11413407B2 (en) | 2017-03-23 | 2022-08-16 | Stamford Devices Ltd. | Aerosol delivery device |
| EP3706773A2 (en) * | 2017-11-10 | 2020-09-16 | Defensin Therapeutics ApS | Maturation of mucosal defense and gut/lung function in the preterm infant |
| MX2020011127A (es) * | 2018-04-23 | 2021-01-15 | Chiesi Farm Spa | Combinacion terapeutica que comprende agente tensioactivo pulmonar y esteroide para la profilaxis de displasia broncopulmonar (bpd). |
| CN109745601B (zh) * | 2019-01-11 | 2024-10-15 | 广州瑞普医疗科技有限公司 | 雾化过程监测方法、系统、计算机设备、存储介质及装置 |
| US20230062996A1 (en) * | 2019-10-11 | 2023-03-02 | Rocket Science Health Corp. | Intranasal drug delivery device, system, and process |
| US11771132B2 (en) | 2020-08-27 | 2023-10-03 | Rai Strategic Holdings, Inc. | Atomization nozzle for aerosol delivery device |
| US20230364355A1 (en) * | 2020-09-28 | 2023-11-16 | Vectura Delivery Devices Limited | Inhalation device |
| EP4272719A4 (en) * | 2020-12-30 | 2024-11-20 | Hexarhumancare Co., Ltd | EXOSKELETON TYPE REHABILITATION ROBOT SYSTEM |
| WO2022154138A1 (ko) * | 2021-01-13 | 2022-07-21 | (주)앰틱스바이오 | 소화성 궤양 창상피복재 분무장치 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4535766A (en) * | 1982-02-23 | 1985-08-20 | Dragerwerk Aktiengesellschaft | Method and apparatus for monitoring a respirator usable with an endotracheal tube |
| US4813431A (en) * | 1987-07-22 | 1989-03-21 | David Brown | Intrapulmonary pressure monitoring system |
| WO1995030448A1 (en) * | 1994-05-06 | 1995-11-16 | Mark Brauner | Methods and apparatus for intrapulmonary therapy and drug administration |
| EP0692273A1 (en) * | 1994-06-17 | 1996-01-17 | Trudell Medical Limited | Nebulizing catheter system and method of manufacture |
| WO2001023025A1 (en) * | 1999-09-27 | 2001-04-05 | Instrumentarium Corporation | Apparatus and method for measuring the intratracheal pressure of an intubated patient |
| EP1426057A1 (en) * | 2002-12-04 | 2004-06-09 | Maquet Critical Care AB | Method of preparation of a medicament and a medical device |
| US20050229926A1 (en) * | 2004-04-20 | 2005-10-20 | Aerogen, Inc. | Method and composition for the treatment of lung surfactant deficiency or dysfunction |
| US20080000470A1 (en) * | 2006-02-10 | 2008-01-03 | Pari Gmbh Spezialisten Fur Effektive Inhalation | Inhalation therapy device for use in premature babies and infants |
| US20090199848A1 (en) * | 2008-02-11 | 2009-08-13 | Micromedics, Inc. | Spray Applicator with Positionable Spray Tip |
| DE102010025045A1 (de) * | 2010-06-22 | 2011-12-22 | Frank Jochum | Vorrichtung zur Gabe von Surfactant(Surfactant Applikator) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US692273A (en) * | 1901-03-16 | 1902-02-04 | Edward J Gulick | Desk-support. |
| GB9307733D0 (en) * | 1993-04-14 | 1993-06-02 | Msa Britain Ltd | Respiratory protective device |
| US5803078A (en) * | 1994-05-06 | 1998-09-08 | Brauner; Mark E. | Methods and apparatus for intrapulmonary therapy and drug administration |
| DE69814918T2 (de) * | 1997-12-17 | 2004-03-11 | Universidad De Sevilla | Vorrichtung und verfahren zur erzeugung von aerosolen für arzneimittelverabreichung |
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| KR101226995B1 (ko) * | 2004-04-20 | 2013-01-28 | 노바르티스 아게 | 압력 보조식 호흡 장치용 에어로졸 전달 장치 |
| CN2905088Y (zh) * | 2006-04-10 | 2007-05-30 | 陈清甫 | 便携式雾化给药装置 |
| HRP20160258T1 (hr) * | 2008-03-17 | 2016-04-22 | Discovery Laboratories, Inc. | Adapter za cijevni sustav ventilacije i proksimalni sustav za dovođenje aerosola |
| PL2110126T3 (pl) * | 2008-04-18 | 2012-04-30 | Novaliq Gmbh | Zastosowanie do inhalacji i zakraplania semifluorowanych alkanów jako nośników substancji aktywnych w strefie wewnątrzpłucnej |
| CN107293314B (zh) * | 2016-03-31 | 2019-03-12 | 光宝电子(广州)有限公司 | 托盘刹车装置 |
-
2013
- 2013-04-12 IN IN9602DEN2014 patent/IN2014DN09602A/en unknown
- 2013-04-12 EA EA201491812A patent/EA027030B1/ru not_active IP Right Cessation
- 2013-04-12 CA CA2870391A patent/CA2870391A1/en not_active Abandoned
- 2013-04-12 PE PE2014001788A patent/PE20150604A1/es not_active Application Discontinuation
- 2013-04-12 CN CN201380026987.8A patent/CN104321103B/zh active Active
- 2013-04-12 SG SG11201406628RA patent/SG11201406628RA/en unknown
- 2013-04-12 BR BR112014026212A patent/BR112014026212A8/pt not_active Application Discontinuation
- 2013-04-12 WO PCT/EP2013/057744 patent/WO2013160129A1/en not_active Ceased
- 2013-04-12 NZ NZ701073A patent/NZ701073A/en not_active IP Right Cessation
- 2013-04-12 MX MX2014012368A patent/MX351677B/es active IP Right Grant
- 2013-04-12 ES ES13715253.4T patent/ES2616082T3/es active Active
- 2013-04-12 JP JP2015506195A patent/JP6293732B2/ja not_active Expired - Fee Related
- 2013-04-12 MA MA37431A patent/MA37431B1/fr unknown
- 2013-04-12 EP EP13715253.4A patent/EP2841135B1/en active Active
- 2013-04-12 KR KR1020147031450A patent/KR102051677B1/ko not_active Expired - Fee Related
- 2013-04-12 AU AU2013251865A patent/AU2013251865B2/en not_active Ceased
- 2013-04-23 US US13/868,436 patent/US10456538B2/en active Active
- 2013-04-23 AR ARP130101353A patent/AR090811A1/es unknown
-
2014
- 2014-10-16 PH PH12014502321A patent/PH12014502321A1/en unknown
- 2014-10-16 TN TN2014000429A patent/TN2014000429A1/fr unknown
- 2014-10-17 ZA ZA2014/07557A patent/ZA201407557B/en unknown
- 2014-10-19 IL IL235143A patent/IL235143A0/en unknown
- 2014-10-23 CO CO14235215A patent/CO7160044A2/es unknown
- 2014-10-23 CL CL2014002863A patent/CL2014002863A1/es unknown
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4535766A (en) * | 1982-02-23 | 1985-08-20 | Dragerwerk Aktiengesellschaft | Method and apparatus for monitoring a respirator usable with an endotracheal tube |
| US4813431A (en) * | 1987-07-22 | 1989-03-21 | David Brown | Intrapulmonary pressure monitoring system |
| WO1995030448A1 (en) * | 1994-05-06 | 1995-11-16 | Mark Brauner | Methods and apparatus for intrapulmonary therapy and drug administration |
| EP0692273A1 (en) * | 1994-06-17 | 1996-01-17 | Trudell Medical Limited | Nebulizing catheter system and method of manufacture |
| WO2001023025A1 (en) * | 1999-09-27 | 2001-04-05 | Instrumentarium Corporation | Apparatus and method for measuring the intratracheal pressure of an intubated patient |
| EP1426057A1 (en) * | 2002-12-04 | 2004-06-09 | Maquet Critical Care AB | Method of preparation of a medicament and a medical device |
| US20050229926A1 (en) * | 2004-04-20 | 2005-10-20 | Aerogen, Inc. | Method and composition for the treatment of lung surfactant deficiency or dysfunction |
| US20080000470A1 (en) * | 2006-02-10 | 2008-01-03 | Pari Gmbh Spezialisten Fur Effektive Inhalation | Inhalation therapy device for use in premature babies and infants |
| US20090199848A1 (en) * | 2008-02-11 | 2009-08-13 | Micromedics, Inc. | Spray Applicator with Positionable Spray Tip |
| DE102010025045A1 (de) * | 2010-06-22 | 2011-12-22 | Frank Jochum | Vorrichtung zur Gabe von Surfactant(Surfactant Applikator) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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