EA026867B1 - Противоопухолевые комбинации, содержащие мелфалан и антитела, которые специфично распознают cd38 - Google Patents
Противоопухолевые комбинации, содержащие мелфалан и антитела, которые специфично распознают cd38 Download PDFInfo
- Publication number
- EA026867B1 EA026867B1 EA201100864A EA201100864A EA026867B1 EA 026867 B1 EA026867 B1 EA 026867B1 EA 201100864 A EA201100864 A EA 201100864A EA 201100864 A EA201100864 A EA 201100864A EA 026867 B1 EA026867 B1 EA 026867B1
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- Eurasian Patent Office
- Prior art keywords
- amino acid
- acid sequences
- chain contains
- antibody
- light chain
- Prior art date
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- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title claims abstract description 39
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08291116A EP2191840A1 (en) | 2008-11-28 | 2008-11-28 | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
| PCT/IB2009/055389 WO2010061357A1 (en) | 2008-11-28 | 2009-11-27 | Antitumor combinations containing antibodies recognizing specifically cd38 and melphalan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201100864A1 EA201100864A1 (ru) | 2011-12-30 |
| EA026867B1 true EA026867B1 (ru) | 2017-05-31 |
Family
ID=40578382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201100864A EA026867B1 (ru) | 2008-11-28 | 2009-11-27 | Противоопухолевые комбинации, содержащие мелфалан и антитела, которые специфично распознают cd38 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9259406B2 (OSRAM) |
| EP (2) | EP2191840A1 (OSRAM) |
| JP (3) | JP2012510461A (OSRAM) |
| KR (1) | KR101733252B1 (OSRAM) |
| CN (1) | CN102264385B (OSRAM) |
| AR (1) | AR074219A1 (OSRAM) |
| AU (1) | AU2009321249B2 (OSRAM) |
| BR (1) | BRPI0921864B1 (OSRAM) |
| CA (1) | CA2744990C (OSRAM) |
| CL (1) | CL2011001254A1 (OSRAM) |
| CO (1) | CO6440557A2 (OSRAM) |
| CR (1) | CR20110280A (OSRAM) |
| EA (1) | EA026867B1 (OSRAM) |
| EC (1) | ECSP11011062A (OSRAM) |
| HN (1) | HN2011001417A (OSRAM) |
| IL (1) | IL213116B (OSRAM) |
| MA (1) | MA32896B1 (OSRAM) |
| ME (1) | ME01136B (OSRAM) |
| MX (1) | MX342625B (OSRAM) |
| MY (1) | MY164577A (OSRAM) |
| NI (1) | NI201100105A (OSRAM) |
| NZ (1) | NZ593027A (OSRAM) |
| PA (1) | PA8850101A1 (OSRAM) |
| PE (1) | PE20120340A1 (OSRAM) |
| SG (1) | SG171820A1 (OSRAM) |
| SV (1) | SV2011003924A (OSRAM) |
| TN (1) | TN2011000232A1 (OSRAM) |
| TW (1) | TWI454260B (OSRAM) |
| UA (1) | UA107069C2 (OSRAM) |
| UY (1) | UY32263A (OSRAM) |
| WO (1) | WO2010061357A1 (OSRAM) |
| ZA (1) | ZA201103925B (OSRAM) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0816777B2 (ja) | 1988-10-13 | 1996-02-21 | 富士写真フイルム株式会社 | 画像形成方法 |
| EP2191840A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
| CA2796464C (en) * | 2010-04-16 | 2021-08-03 | Immune Disease Institute, Inc. | Sustained polypeptide expression from synthetic, modified rnas and uses thereof |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| ES2617446T3 (es) | 2010-09-27 | 2017-06-19 | Morphosys Ag | Anticuerpo anti-cd38 y lenalidomida o bortezomib para el tratamiento del mieloma múltiple y nhl |
| CN103429606A (zh) | 2010-10-01 | 2013-12-04 | 现代治疗公司 | 设计核酸及其使用方法 |
| UA112170C2 (uk) * | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
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