EA024193B1 - Фармацевтическая композиция на водной основе, предназначенная для парентерального введения тапентадола - Google Patents
Фармацевтическая композиция на водной основе, предназначенная для парентерального введения тапентадола Download PDFInfo
- Publication number
- EA024193B1 EA024193B1 EA201300990A EA201300990A EA024193B1 EA 024193 B1 EA024193 B1 EA 024193B1 EA 201300990 A EA201300990 A EA 201300990A EA 201300990 A EA201300990 A EA 201300990A EA 024193 B1 EA024193 B1 EA 024193B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- composition
- tapentadol
- pain
- accordance
- administration
- Prior art date
Links
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- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- XZPVPNZTYPUODG-UHFFFAOYSA-M sodium;chloride;dihydrate Chemical compound O.O.[Na+].[Cl-] XZPVPNZTYPUODG-UHFFFAOYSA-M 0.000 description 1
- CEHCOJSZSZWUIG-UHFFFAOYSA-M sodium;propyl sulfate Chemical compound [Na+].CCCOS([O-])(=O)=O CEHCOJSZSZWUIG-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 229960004739 sufentanil Drugs 0.000 description 1
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960003279 thiopental Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229960000834 vinyl ether Drugs 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201161449317P | 2011-03-04 | 2011-03-04 | |
| EP11003602 | 2011-05-03 | ||
| PCT/EP2012/000905 WO2012119728A1 (en) | 2011-03-04 | 2012-03-02 | Parenteral administration of tapentadol |
Publications (2)
| Publication Number | Publication Date |
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| EA201300990A1 EA201300990A1 (ru) | 2014-02-28 |
| EA024193B1 true EA024193B1 (ru) | 2016-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| EA201300990A EA024193B1 (ru) | 2011-03-04 | 2012-03-02 | Фармацевтическая композиция на водной основе, предназначенная для парентерального введения тапентадола |
| EA201600088A EA028149B1 (ru) | 2011-03-04 | 2012-03-02 | Парентеральное введение тапентадола |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201600088A EA028149B1 (ru) | 2011-03-04 | 2012-03-02 | Парентеральное введение тапентадола |
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| US (3) | US20120225951A1 (enExample) |
| EP (2) | EP2680833B1 (enExample) |
| JP (4) | JP2014510067A (enExample) |
| KR (2) | KR101903351B1 (enExample) |
| CN (2) | CN107088226A (enExample) |
| AU (2) | AU2012224953C1 (enExample) |
| BR (1) | BR112013022213A2 (enExample) |
| CA (1) | CA2828635C (enExample) |
| CY (1) | CY1117426T1 (enExample) |
| DK (1) | DK2680833T3 (enExample) |
| EA (2) | EA024193B1 (enExample) |
| ES (1) | ES2573414T3 (enExample) |
| HR (1) | HRP20160400T1 (enExample) |
| HU (1) | HUE027514T2 (enExample) |
| IL (1) | IL227825A (enExample) |
| MX (1) | MX348831B (enExample) |
| PL (1) | PL2680833T3 (enExample) |
| PT (1) | PT2680833E (enExample) |
| RS (1) | RS54711B1 (enExample) |
| SI (1) | SI2680833T1 (enExample) |
| WO (1) | WO2012119728A1 (enExample) |
| ZA (1) | ZA201306479B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011267474B2 (en) | 2010-06-15 | 2016-05-26 | Grünenthal GmbH | Pharmaceutical combination for the treatment of pain |
| EP3685827A1 (en) | 2011-03-04 | 2020-07-29 | Grünenthal GmbH | Aqueous pharmaceutical formulation of tapentadol for oral administration |
| EP3300726A1 (en) * | 2011-07-29 | 2018-04-04 | Grünenthal GmbH | Intrathecal or epidural administration of 3-[(1s,2s)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol |
| BR112015009839A2 (pt) * | 2012-11-01 | 2017-07-11 | Torrent Pharmaceuticals Ltd | composição farmacêutica de tapentadol para administração parenteral |
| EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
| EP2845625A1 (en) | 2013-09-04 | 2015-03-11 | Grünenthal GmbH | Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome |
| CN103735500B (zh) * | 2014-01-28 | 2016-01-20 | 江苏华泽医药科技有限公司 | 盐酸他喷他多注射液及其制备方法 |
| JP6923447B2 (ja) * | 2015-03-27 | 2021-08-18 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールの非経口投与のための安定な製剤 |
| EP3515412B1 (en) * | 2016-09-23 | 2025-04-23 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| WO2018153947A1 (en) | 2017-02-23 | 2018-08-30 | Grünenthal GmbH | Tapentadol as local anesthetic |
| CN113825500A (zh) * | 2019-05-16 | 2021-12-21 | 奈克瑟斯药物公司 | 包含麻黄碱或麻黄碱盐的组合物及其制备和使用方法 |
| EP4011369A1 (en) * | 2020-12-14 | 2022-06-15 | G.L. Pharma GmbH | Aqueous pharmaceutical composition comprising tapentadol tartrate |
| CN114788814B (zh) * | 2021-01-26 | 2023-10-13 | 浙江创新生物有限公司 | 一种高稳定性的注射用达托霉素组合物及其制备方法和其应用 |
Citations (4)
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| WO2002067651A2 (de) * | 2001-02-28 | 2002-09-06 | Grünenthal GmbH | Pharmazeutisch salze |
| WO2007128412A1 (en) * | 2006-04-28 | 2007-11-15 | Grünenthal GmbH | Pharmaceutical combination comprising 3- (3-dimethylamin0-1-ethyl-2-methyl-pr0pyl) -phenol and an nsaid |
| WO2008110323A1 (de) * | 2007-03-12 | 2008-09-18 | Grünenthal GmbH | Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie des neuropathieschmerzes |
| US20100272815A1 (en) * | 2009-04-28 | 2010-10-28 | Actavis Group Ptc Ehf | Amorphous form of tapentadol hydrochloride |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8334422D0 (en) * | 1983-12-23 | 1984-02-01 | Sterwin Ag | Composition |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| JP2004516233A (ja) * | 2000-04-27 | 2004-06-03 | ファイザー・プロダクツ・インク | 哺乳動物の細菌若しくは原生動物感染症を治療するか又は予防するためのアザライド抗生組成物の使用 |
| EP1282416A2 (en) * | 2000-05-19 | 2003-02-12 | Progenics Pharmaceuticals, Inc. | Dehydroascorbic acid formulations and uses thereof |
| US6399087B1 (en) * | 2000-12-20 | 2002-06-04 | Amphastar Pharmaceuticals, Inc. | Propofol formulation with enhanced microbial inhibition |
| JP4905616B2 (ja) * | 2001-04-19 | 2012-03-28 | ライオン株式会社 | ソフトコンタクトレンズ用点眼剤 |
| PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
| US20030191187A1 (en) * | 2002-04-01 | 2003-10-09 | Lee Fang Yu | Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same |
| US20040180915A1 (en) * | 2003-03-14 | 2004-09-16 | Xanodyne Pharmacal, Inc. | Methadone-containing compositions for parenteral administration and method of use thereof |
| ES2291780T3 (es) * | 2004-06-28 | 2008-03-01 | Grunenthal Gmbh | Formas cristalinas del clorhidrato de (-)-(1r,2r)-3-(3-dimetilamino-1-etil-2-metilpropil)fenol. |
| AR053304A1 (es) | 2004-07-01 | 2007-05-02 | Gruenenthal Gmbh | Formas farmaceuticas orales protegidas frente al abuso con liberacion controlada de (1r,2r)-3-(3 dimetilamino-1-etil-2metil-propil)fenol y procedimiento para su produccion. |
| CA2606947A1 (en) * | 2005-04-28 | 2006-11-02 | Theraquest Biosciences Llc | Methods and compositions for treating pain |
| EP1965828A2 (en) * | 2005-12-02 | 2008-09-10 | Nastech Pharmaceutical Company Inc. | Pharmaceutical formulation for increased epithelial permeability of glucose-regulating peptide |
| CN101431990B (zh) * | 2006-04-28 | 2011-08-03 | 格吕伦塔尔有限公司 | 包含3-（3-二甲基氨基-1-乙基-2-甲基-丙基）-酚和对乙酰氨基酚的药物结合 |
| SI2046726T1 (sl) * | 2006-07-24 | 2010-05-31 | Janssen Pharmaceutica Nv | Priprava R R metoksifenil N N trimetilpentanamina |
| EP1905440A1 (de) * | 2006-09-06 | 2008-04-02 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verwendung einer pharmazeutischen Zusammensetzung enthaltend ein Anticholinergikum zur Abtötung von Mikroorganismen und zur Behandlung von Atemwegsinfektionen |
| TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
| JP2008266168A (ja) * | 2007-04-18 | 2008-11-06 | Teika Seiyaku Kk | 眼科用剤 |
| EP1985292A1 (en) * | 2007-04-23 | 2008-10-29 | Grünenthal GmbH | Titration of tapentadol |
| MX2010005680A (es) | 2007-11-23 | 2010-12-21 | Protect Pharmaceutical Corp | Composiciones de tapentadol. |
| TWI454288B (zh) | 2008-01-25 | 2014-10-01 | Gruenenthal Chemie | 藥物劑型 |
| WO2010025931A2 (en) * | 2008-09-05 | 2010-03-11 | Grünenthal GmbH | Pharmaceutical combination |
| EP2246044A1 (en) * | 2009-04-21 | 2010-11-03 | Pierre Fabre Dermo-Cosmétique | Paediatric solutions comprising a beta-blocker |
| CN101961315B (zh) * | 2010-09-10 | 2012-09-05 | 海南美兰史克制药有限公司 | 一种门冬氨酸鸟氨酸脂质体注射液 |
-
2012
- 2012-03-02 PL PL12709792T patent/PL2680833T3/pl unknown
- 2012-03-02 DK DK12709792.1T patent/DK2680833T3/en active
- 2012-03-02 EA EA201300990A patent/EA024193B1/ru not_active IP Right Cessation
- 2012-03-02 CN CN201710217173.2A patent/CN107088226A/zh active Pending
- 2012-03-02 SI SI201230554A patent/SI2680833T1/sl unknown
- 2012-03-02 EA EA201600088A patent/EA028149B1/ru not_active IP Right Cessation
- 2012-03-02 KR KR1020137026184A patent/KR101903351B1/ko not_active Expired - Fee Related
- 2012-03-02 BR BR112013022213A patent/BR112013022213A2/pt not_active Application Discontinuation
- 2012-03-02 MX MX2013010046A patent/MX348831B/es active IP Right Grant
- 2012-03-02 PT PT127097921T patent/PT2680833E/pt unknown
- 2012-03-02 CA CA2828635A patent/CA2828635C/en not_active Expired - Fee Related
- 2012-03-02 WO PCT/EP2012/000905 patent/WO2012119728A1/en not_active Ceased
- 2012-03-02 ES ES12709792.1T patent/ES2573414T3/es active Active
- 2012-03-02 EP EP12709792.1A patent/EP2680833B1/en not_active Not-in-force
- 2012-03-02 RS RS20160287A patent/RS54711B1/sr unknown
- 2012-03-02 JP JP2013555797A patent/JP2014510067A/ja active Pending
- 2012-03-02 AU AU2012224953A patent/AU2012224953C1/en not_active Ceased
- 2012-03-02 HR HRP20160400TT patent/HRP20160400T1/hr unknown
- 2012-03-02 US US13/410,945 patent/US20120225951A1/en not_active Abandoned
- 2012-03-02 HU HUE12709792A patent/HUE027514T2/en unknown
- 2012-03-02 EP EP15200814.0A patent/EP3025710A1/en not_active Withdrawn
- 2012-03-02 CN CN201280011685.9A patent/CN103501775A/zh active Pending
- 2012-03-02 KR KR1020187015692A patent/KR101970468B1/ko not_active Expired - Fee Related
-
2013
- 2013-08-06 IL IL227825A patent/IL227825A/en active IP Right Grant
- 2013-08-28 ZA ZA2013/06479A patent/ZA201306479B/en unknown
-
2015
- 2015-12-28 US US14/981,223 patent/US20160106688A1/en not_active Abandoned
-
2016
- 2016-04-11 CY CY20161100291T patent/CY1117426T1/el unknown
-
2017
- 2017-04-04 AU AU2017202214A patent/AU2017202214B2/en not_active Ceased
- 2017-08-21 JP JP2017158324A patent/JP6837944B2/ja not_active Expired - Fee Related
-
2020
- 2020-03-13 US US16/818,275 patent/US20200215003A1/en not_active Abandoned
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2021
- 2021-12-01 JP JP2021195330A patent/JP2022033863A/ja active Pending
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2023
- 2023-03-10 JP JP2023037505A patent/JP2023075244A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002067651A2 (de) * | 2001-02-28 | 2002-09-06 | Grünenthal GmbH | Pharmazeutisch salze |
| WO2007128412A1 (en) * | 2006-04-28 | 2007-11-15 | Grünenthal GmbH | Pharmaceutical combination comprising 3- (3-dimethylamin0-1-ethyl-2-methyl-pr0pyl) -phenol and an nsaid |
| WO2008110323A1 (de) * | 2007-03-12 | 2008-09-18 | Grünenthal GmbH | Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie des neuropathieschmerzes |
| US20100272815A1 (en) * | 2009-04-28 | 2010-10-28 | Actavis Group Ptc Ehf | Amorphous form of tapentadol hydrochloride |
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| TZSCHENTKE T.M. ET AL.: "Tapentadol hydrochloride. Analgesic, Mu-opioid receptor agonist, noradrenaline reuptake inhibitor.", DRUGS OF THE FUTURE, vol. 31, no. 12, December 2006 (2006-12), pages 1053-1061, XP002660111, ISSN: 0377-8282 the whole document * |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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