EA022422B1 - Пептидные производные, их получение и применение - Google Patents
Пептидные производные, их получение и применение Download PDFInfo
- Publication number
- EA022422B1 EA022422B1 EA201201446A EA201201446A EA022422B1 EA 022422 B1 EA022422 B1 EA 022422B1 EA 201201446 A EA201201446 A EA 201201446A EA 201201446 A EA201201446 A EA 201201446A EA 022422 B1 EA022422 B1 EA 022422B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- peptide
- peptides
- brain
- blood
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1053036A FR2959229B1 (fr) | 2010-04-21 | 2010-04-21 | Derives peptidiques, leur preparation et leurs utilisations |
| PCT/FR2011/050883 WO2011131896A2 (fr) | 2010-04-21 | 2011-04-18 | Derives peptidiques, leur preparation et leurs utilisations comme vecteurs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201201446A1 EA201201446A1 (ru) | 2013-04-30 |
| EA022422B1 true EA022422B1 (ru) | 2015-12-30 |
Family
ID=43365640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201201446A EA022422B1 (ru) | 2010-04-21 | 2011-04-18 | Пептидные производные, их получение и применение |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8877716B2 (es) |
| EP (1) | EP2547692B1 (es) |
| JP (1) | JP6073779B2 (es) |
| CN (1) | CN103119052B (es) |
| AU (1) | AU2011244107B2 (es) |
| BR (1) | BR112012027043B1 (es) |
| CA (1) | CA2796174C (es) |
| DK (2) | DK2547692T5 (es) |
| EA (1) | EA022422B1 (es) |
| ES (2) | ES2637265T3 (es) |
| FR (1) | FR2959229B1 (es) |
| HU (2) | HUE035416T2 (es) |
| PL (1) | PL2547692T3 (es) |
| TR (1) | TR201905058T4 (es) |
| WO (1) | WO2011131896A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003222568B2 (en) | 2002-01-11 | 2009-05-07 | Bioasis Technologies, Inc. | Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
| FR2937322B1 (fr) | 2008-10-22 | 2013-02-22 | Vect Horus | Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues |
| FR2959229B1 (fr) | 2010-04-21 | 2013-01-18 | Vect Horus | Derives peptidiques, leur preparation et leurs utilisations |
| JP6082901B2 (ja) * | 2011-01-31 | 2017-02-22 | オリンパス株式会社 | ワクチン・アジュバント |
| CN103747807B (zh) | 2011-07-05 | 2016-12-07 | 比奥阿赛斯技术有限公司 | P97‑抗体缀合物和使用方法 |
| EP2880156B1 (en) | 2012-07-31 | 2017-08-23 | biOasis Technologies Inc | Dephosphorylated lysosomal storage disease proteins and methods of use thereof |
| JP6426100B2 (ja) * | 2012-10-19 | 2018-11-21 | ヴェクト−オリュスＶｅｃｔ−Ｈｏｒｕｓ | 薬物送達のための組成物及び方法 |
| WO2014160438A1 (en) | 2013-03-13 | 2014-10-02 | Bioasis Technologies Inc. | Fragments of p97 and uses thereof |
| CN104117069A (zh) * | 2013-04-26 | 2014-10-29 | 复旦大学 | 一种针对脑胶质瘤的靶向纳米递药系统及其制备方法和应用 |
| EP3038657A2 (en) | 2013-08-28 | 2016-07-06 | Bioasis Technologies Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
| EP2896402A1 (en) * | 2014-01-20 | 2015-07-22 | Vect-Horus | Activated neurotensin molecules and the uses thereof |
| CA2935195A1 (en) | 2014-02-03 | 2015-08-06 | Bioasis Technologies, Inc. | P97 fusion proteins |
| DK3107562T3 (da) | 2014-02-19 | 2019-12-16 | Bioasis Technologies Inc | P97-ids-fusionsproteiner |
| CA2943890A1 (en) | 2014-05-01 | 2015-11-05 | Bioasis Technologies, Inc. | P97-polynucleotide conjugates |
| US20160215031A1 (en) * | 2015-01-27 | 2016-07-28 | Nymox Pharnaceutical Corporation | Method of treating disorders requiring destruction or removal of cells |
| US20190085093A1 (en) * | 2015-11-17 | 2019-03-21 | Seoul National University R&Db Foundation | Composition for regulating cell division comprising fcho1 modulator, and method for regulating cell division using same |
| WO2018052948A1 (en) | 2016-09-13 | 2018-03-22 | Angiocrine Bioscience, Inc. | Blood-brain barrier comprising engineered endothelial cells |
| CN110312549B (zh) | 2016-12-19 | 2021-06-29 | 莫尔豪斯医学院 | 用于通过抑制外泌体释放来治疗疾病的组合物和方法 |
| WO2018138372A1 (en) * | 2017-01-30 | 2018-08-02 | Vect-Horus | Compositions and methods for cancer imaging and radiotherapy |
| US10688191B2 (en) | 2018-01-19 | 2020-06-23 | Hr Biomed, Llc | Delivery of a chemotherapy agent across the blood-brain barrier |
| JP2022518392A (ja) | 2019-01-09 | 2022-03-15 | ヴェクト－オール | トランスフェリン受容体結合分子、そのコンジュゲート、及びその使用 |
| CA3128035A1 (en) | 2020-08-13 | 2022-02-13 | Bioasis Technologies, Inc. | Combination therapies for delivery across the blood brain barrier |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001081581A2 (en) * | 2000-04-21 | 2001-11-01 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of acne vulgaris |
| US20040123343A1 (en) * | 2000-04-19 | 2004-06-24 | La Rosa Thomas J. | Rice nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| WO2004108071A2 (en) * | 2003-06-05 | 2004-12-16 | Salk Institute For Biological Studies | Targeting polypeptides to the central nervous system |
| WO2010046588A1 (fr) * | 2008-10-22 | 2010-04-29 | Vect-Horus | Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047566A1 (en) | 1998-03-17 | 1999-09-23 | The Uab Research Foundation | Synthetic peptides that enhance ldl uptake |
| US20040031072A1 (en) * | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| CN1388131A (zh) * | 2002-06-10 | 2003-01-01 | 牛勃 | 系列新型药物载体、新型载体－酪氨酸羟化酶融合蛋白及其制备 |
| AR053269A1 (es) * | 2005-05-16 | 2007-04-25 | Monsanto Technology Llc | Plantas y semillas de maiz con mejoramiento de asparagina y proteina |
| CN101490270A (zh) * | 2005-07-19 | 2009-07-22 | 伊利诺斯大学理事会 | 用于穿越血脑屏障并进入脑部癌细胞的转运剂及其使用方法 |
| FR2889532B1 (fr) | 2005-08-03 | 2007-10-12 | Lab Francais Du Fractionnement | Anticorps diriges contre le recepteur du ldl |
| FR2959229B1 (fr) | 2010-04-21 | 2013-01-18 | Vect Horus | Derives peptidiques, leur preparation et leurs utilisations |
-
2010
- 2010-04-21 FR FR1053036A patent/FR2959229B1/fr active Active
-
2011
- 2011-04-18 DK DK11731421.1T patent/DK2547692T5/en active
- 2011-04-18 CA CA2796174A patent/CA2796174C/en active Active
- 2011-04-18 AU AU2011244107A patent/AU2011244107B2/en active Active
- 2011-04-18 PL PL11731421T patent/PL2547692T3/pl unknown
- 2011-04-18 EP EP11731421.1A patent/EP2547692B1/fr active Active
- 2011-04-18 JP JP2013505522A patent/JP6073779B2/ja active Active
- 2011-04-18 WO PCT/FR2011/050883 patent/WO2011131896A2/fr active Application Filing
- 2011-04-18 BR BR112012027043-5A patent/BR112012027043B1/pt active IP Right Grant
- 2011-04-18 ES ES11731421.1T patent/ES2637265T3/es active Active
- 2011-04-18 HU HUE11731421A patent/HUE035416T2/en unknown
- 2011-04-18 CN CN201180030014.2A patent/CN103119052B/zh active Active
- 2011-04-18 EA EA201201446A patent/EA022422B1/ru not_active IP Right Cessation
-
2012
- 2012-10-19 US US13/655,954 patent/US8877716B2/en active Active
-
2013
- 2013-10-18 DK DK13783290.3T patent/DK2908837T3/en active
- 2013-10-18 ES ES13783290T patent/ES2719727T3/es active Active
- 2013-10-18 HU HUE13783290A patent/HUE042850T2/hu unknown
- 2013-10-18 TR TR2019/05058T patent/TR201905058T4/tr unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040123343A1 (en) * | 2000-04-19 | 2004-06-24 | La Rosa Thomas J. | Rice nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| WO2001081581A2 (en) * | 2000-04-21 | 2001-11-01 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of acne vulgaris |
| WO2004108071A2 (en) * | 2003-06-05 | 2004-12-16 | Salk Institute For Biological Studies | Targeting polypeptides to the central nervous system |
| WO2010046588A1 (fr) * | 2008-10-22 | 2010-04-29 | Vect-Horus | Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues |
Non-Patent Citations (1)
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011131896A3 (fr) | 2012-01-19 |
| JP2013525336A (ja) | 2013-06-20 |
| AU2011244107B2 (en) | 2015-07-16 |
| DK2908837T3 (en) | 2019-04-23 |
| TR201905058T4 (tr) | 2019-05-21 |
| CA2796174C (en) | 2018-07-17 |
| DK2547692T3 (en) | 2017-09-04 |
| BR112012027043A2 (pt) | 2016-12-06 |
| DK2547692T5 (en) | 2017-09-25 |
| EP2547692A2 (fr) | 2013-01-23 |
| CA2796174A1 (en) | 2011-10-27 |
| EA201201446A1 (ru) | 2013-04-30 |
| US20130108548A1 (en) | 2013-05-02 |
| CN103119052B (zh) | 2016-06-01 |
| US8877716B2 (en) | 2014-11-04 |
| ES2637265T3 (es) | 2017-10-11 |
| HUE035416T2 (en) | 2018-05-02 |
| AU2011244107A1 (en) | 2012-11-08 |
| FR2959229A1 (fr) | 2011-10-28 |
| FR2959229B1 (fr) | 2013-01-18 |
| ES2719727T3 (es) | 2019-07-12 |
| WO2011131896A2 (fr) | 2011-10-27 |
| PL2547692T3 (pl) | 2018-08-31 |
| BR112012027043B1 (pt) | 2022-03-22 |
| CN103119052A (zh) | 2013-05-22 |
| JP6073779B2 (ja) | 2017-02-01 |
| EP2547692B1 (fr) | 2017-05-17 |
| HUE042850T2 (hu) | 2019-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM KG MD TJ TM |