EA020045B1 - Комбинированная терапия соединением, проявляющим активность ингибитора рецептора адф на тромбоцитах - Google Patents
Комбинированная терапия соединением, проявляющим активность ингибитора рецептора адф на тромбоцитах Download PDFInfo
- Publication number
- EA020045B1 EA020045B1 EA200901442A EA200901442A EA020045B1 EA 020045 B1 EA020045 B1 EA 020045B1 EA 200901442 A EA200901442 A EA 200901442A EA 200901442 A EA200901442 A EA 200901442A EA 020045 B1 EA020045 B1 EA 020045B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutically acceptable
- compound
- acceptable salt
- therapeutic agents
- administered
- Prior art date
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- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Immunology (AREA)
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- Vascular Medicine (AREA)
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- Endocrinology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
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| US91564907P | 2007-05-02 | 2007-05-02 | |
| US91591107P | 2007-05-03 | 2007-05-03 | |
| US94792107P | 2007-07-03 | 2007-07-03 | |
| US97870007P | 2007-10-09 | 2007-10-09 | |
| PCT/US2008/062561 WO2008137787A2 (en) | 2007-05-02 | 2008-05-02 | Combination therapy with a compound acting as a platelet adp receptor inhibitor |
Publications (2)
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| EA200901442A1 EA200901442A1 (ru) | 2010-06-30 |
| EA020045B1 true EA020045B1 (ru) | 2014-08-29 |
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| NZ (2) | NZ581324A (https=) |
| PT (1) | PT2146705E (https=) |
| TN (1) | TN2009000444A1 (https=) |
| WO (1) | WO2008137787A2 (https=) |
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| EP1945632B1 (en) | 2005-11-08 | 2013-09-18 | Vertex Pharmaceuticals Incorporated | Heterocyclic modulators of atp-binding cassette transporters |
| US20090186810A1 (en) * | 2006-03-27 | 2009-07-23 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
| NZ572418A (en) * | 2006-05-05 | 2011-08-26 | Millennium Pharm Inc | Factor xa inhibitors |
| CN101595092B (zh) | 2006-11-02 | 2012-02-01 | 米伦纽姆医药公司 | 合成因子xa抑制剂的医药盐的方法 |
| WO2008086226A2 (en) * | 2007-01-05 | 2008-07-17 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| EA020531B1 (ru) * | 2007-04-13 | 2014-11-28 | Милленниум Фармасьютикалз, Инк. | КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИКОАГУЛИРУЮЩЕГО СРЕДСТВА С СОЕДИНЕНИЕМ, КОТОРОЕ ДЕЙСТВУЕТ КАК ИНГИБИТОР ФАКТОРА Ха |
| SI2225230T1 (sl) | 2007-12-07 | 2017-03-31 | Vertex Pharmaceuticals Incorporated | Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline |
| AU2009313867A1 (en) * | 2008-11-14 | 2011-06-30 | Patheon Inc. | Solid composition for controlled release of ionizable active agents with poor aqueous solubility at low pH and methods of use thereof |
| CN102762550B (zh) | 2009-12-17 | 2015-04-01 | 米伦纽姆医药公司 | Xa因子抑制剂的盐和结晶形式 |
| US8742120B2 (en) | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| EP2633857B1 (en) * | 2009-12-23 | 2015-08-12 | ratiopharm GmbH | Solid pharmaceutical dosage form of ticagrelor and acetylsalicylic acid |
| JP2013518034A (ja) * | 2010-01-21 | 2013-05-20 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 薬物として使用するための特別な組成物 |
| SI2538925T1 (sl) * | 2010-02-25 | 2016-04-29 | Bristol-Myers Squibb Company | Apiksaban formulacije |
| HRP20211752T1 (hr) | 2010-04-07 | 2022-02-18 | Vertex Pharmaceuticals Incorporated | Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena |
| AR082804A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Formas cristalinas de un inhibidor del factor xa |
| RU2597423C2 (ru) * | 2011-03-29 | 2016-09-10 | Санофи | Бензойнокислая соль отамиксабана |
| US20150224091A1 (en) * | 2011-08-31 | 2015-08-13 | Portola Pharmaceuticals, Inc. | Prevention and treatment of thrombosis in medically ill patients |
| WO2013112804A1 (en) | 2012-01-25 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2.2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| WO2014099695A1 (en) * | 2012-12-19 | 2014-06-26 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
| WO2014120346A1 (en) * | 2012-12-19 | 2014-08-07 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
| US9695198B2 (en) | 2012-12-19 | 2017-07-04 | Merck Sharp & Dohme Corp. | Factor IXa inhibitors |
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| JP6963896B2 (ja) | 2013-11-12 | 2021-11-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Ｃｆｔｒ媒介性疾患の処置のための医薬組成物を調製する方法 |
| WO2015123091A1 (en) * | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Factor xia inhibitors |
| CN106831553A (zh) * | 2015-09-11 | 2017-06-13 | 天津科伦药物研究有限公司 | 贝曲西班或其类似物的制备方法 |
| CN105250286A (zh) * | 2015-11-13 | 2016-01-20 | 谭惠娟 | 一种抗血栓组合物 |
| EP3254674A1 (en) * | 2016-06-08 | 2017-12-13 | Sandoz Ag | Pharmaceutical compositions of betrixaban maleate |
| EP3541375B1 (en) | 2016-11-18 | 2023-08-23 | Merck Sharp & Dohme LLC | Factor xiia inhibitors |
| US11654036B2 (en) | 2020-05-26 | 2023-05-23 | Elixir Medical Corporation | Anticoagulant compounds and methods and devices for their use |
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| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020077486A1 (en) * | 2000-02-04 | 2002-06-20 | Scarborough Robert M. | Platelet ADP receptor inhibitors |
| WO2007056219A2 (en) * | 2005-11-03 | 2007-05-18 | Portola Pharmaceuticals, Inc. | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto |
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| CA2684722A1 (en) | 2008-11-13 |
| US20110033459A1 (en) | 2011-02-10 |
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| EP2146705A2 (en) | 2010-01-27 |
| ES2467468T3 (es) | 2014-06-12 |
| CN101686959B (zh) | 2014-05-07 |
| NZ599556A (en) | 2013-10-25 |
| WO2008137787A2 (en) | 2008-11-13 |
| IL201826A0 (en) | 2010-06-16 |
| GT200900283A (es) | 2011-10-05 |
| KR101509829B1 (ko) | 2015-04-06 |
| EA200901442A1 (ru) | 2010-06-30 |
| KR20100023836A (ko) | 2010-03-04 |
| NZ581324A (en) | 2012-05-25 |
| US20080279845A1 (en) | 2008-11-13 |
| EP2146705B1 (en) | 2014-03-05 |
| ECSP099775A (es) | 2010-01-29 |
| EP2586439A1 (en) | 2013-05-01 |
| IL201826A (en) | 2014-08-31 |
| US8946219B2 (en) | 2015-02-03 |
| HK1138765A1 (en) | 2010-09-03 |
| CO6241105A2 (es) | 2011-01-20 |
| WO2008137787A3 (en) | 2009-02-05 |
| JP5439363B2 (ja) | 2014-03-12 |
| MA31396B1 (fr) | 2010-05-03 |
| JP2010526103A (ja) | 2010-07-29 |
| PT2146705E (pt) | 2014-05-23 |
| AU2008247435A1 (en) | 2008-11-13 |
| CN101686959A (zh) | 2010-03-31 |
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