EA019635B1 - Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения - Google Patents
Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения Download PDFInfo
- Publication number
- EA019635B1 EA019635B1 EA200970718A EA200970718A EA019635B1 EA 019635 B1 EA019635 B1 EA 019635B1 EA 200970718 A EA200970718 A EA 200970718A EA 200970718 A EA200970718 A EA 200970718A EA 019635 B1 EA019635 B1 EA 019635B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ligand
- acid
- solid
- modified
- polyoxyhydroxide
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims abstract description 324
- 229910021645 metal ion Inorganic materials 0.000 title claims abstract description 127
- 238000000034 method Methods 0.000 title claims abstract description 109
- 230000008569 process Effects 0.000 title claims abstract description 19
- 239000003446 ligand Substances 0.000 title claims description 176
- 238000002360 preparation method Methods 0.000 title claims description 23
- 239000000126 substance Substances 0.000 claims abstract description 18
- 239000002537 cosmetic Substances 0.000 claims abstract description 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 316
- 239000007790 solid phase Substances 0.000 claims description 157
- 229910052742 iron Inorganic materials 0.000 claims description 150
- -1 polyoxyhydroxide Polymers 0.000 claims description 146
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical group [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 91
- 239000000203 mixture Substances 0.000 claims description 86
- 239000000243 solution Substances 0.000 claims description 74
- 229910001447 ferric ion Inorganic materials 0.000 claims description 69
- 239000000872 buffer Substances 0.000 claims description 40
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims description 38
- 238000004090 dissolution Methods 0.000 claims description 33
- 238000010521 absorption reaction Methods 0.000 claims description 29
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 27
- 238000001556 precipitation Methods 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 22
- 235000013305 food Nutrition 0.000 claims description 22
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 22
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 21
- 238000004458 analytical method Methods 0.000 claims description 21
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- 229910052751 metal Inorganic materials 0.000 claims description 21
- 239000002184 metal Substances 0.000 claims description 21
- 125000004043 oxo group Chemical group O=* 0.000 claims description 21
- 230000008859 change Effects 0.000 claims description 20
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims description 19
- 239000003792 electrolyte Substances 0.000 claims description 19
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims description 17
- 238000012384 transportation and delivery Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 16
- 239000007993 MOPS buffer Substances 0.000 claims description 16
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 16
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 16
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- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 15
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 15
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 14
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 13
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 13
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- 238000006243 chemical reaction Methods 0.000 claims description 13
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- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 12
- 229960003512 nicotinic acid Drugs 0.000 claims description 12
- 239000011664 nicotinic acid Substances 0.000 claims description 12
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 12
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 11
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 11
- 229910019142 PO4 Inorganic materials 0.000 claims description 11
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- 239000013589 supplement Substances 0.000 claims description 11
- 229940095064 tartrate Drugs 0.000 claims description 11
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 10
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 10
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 10
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- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 9
- 235000015872 dietary supplement Nutrition 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 9
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 9
- 235000012141 vanillin Nutrition 0.000 claims description 9
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- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 8
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- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 3
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
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- IZXGZAJMDLJLMF-UHFFFAOYSA-N methylaminomethanol Chemical compound CNCO IZXGZAJMDLJLMF-UHFFFAOYSA-N 0.000 claims 3
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G99/00—Subject matter not provided for in other groups of this subclass
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Polyesters Or Polycarbonates (AREA)
- Cosmetics (AREA)
- Catalysts (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88838607P | 2007-02-06 | 2007-02-06 | |
| GBGB0702270.0A GB0702270D0 (en) | 2007-02-06 | 2007-02-06 | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| PCT/GB2008/000408 WO2008096130A1 (en) | 2007-02-06 | 2008-02-06 | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
Publications (2)
| Publication Number | Publication Date |
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| EA200970718A1 EA200970718A1 (ru) | 2010-02-26 |
| EA019635B1 true EA019635B1 (ru) | 2014-05-30 |
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| EP (1) | EP2125847B1 (OSRAM) |
| JP (1) | JP5756598B2 (OSRAM) |
| KR (1) | KR101514470B1 (OSRAM) |
| AU (1) | AU2008212653B2 (OSRAM) |
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| CA (1) | CA2676146C (OSRAM) |
| CY (1) | CY1116590T1 (OSRAM) |
| EA (1) | EA019635B1 (OSRAM) |
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| HR (1) | HRP20150944T1 (OSRAM) |
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| PL (1) | PL2125847T3 (OSRAM) |
| WO (1) | WO2008096130A1 (OSRAM) |
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| KR101514470B1 (ko) | 2007-02-06 | 2015-04-22 | 메디칼 리서취 카운실 | 리간드 개질 폴리 옥소-히드록시 금속 이온 물질, 이의 용도 및 이의 제조 방법 |
| GB0814326D0 (en) * | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
| GB201101299D0 (en) | 2011-01-25 | 2011-03-09 | Medical Res Council | Oxygen sensors and their uses |
| GB201507002D0 (en) * | 2015-04-24 | 2015-06-10 | Medical Res Council | Copper Oxo-hydroxide nanoparticles and their uses as biocidal agents |
| GB201517893D0 (en) * | 2015-10-09 | 2015-11-25 | Medical Res Council | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids |
| EP3436440B1 (en) | 2016-03-31 | 2020-10-21 | Shield TX (UK) Limited | Methods for producing ferric maltol compositions from ligand modified and ligand coated ferric hydroxides |
| EP3436442B1 (en) | 2016-03-31 | 2020-10-28 | Shield TX (UK) Limited | Methods for producing ferric maltol compositions from ferrous hydroxides |
| ES2879881T3 (es) | 2016-08-10 | 2021-11-23 | Res & Innovation Uk | Composiciones que comprenden partículas de nanosílice y su uso en métodos de activación de linfocitos T para terapia |
| EP4559468A3 (en) | 2017-09-11 | 2025-06-25 | Pharmacosmos Holding A/s | Iron complex compounds for therapeutic use |
| GB202005054D0 (en) | 2020-04-06 | 2020-05-20 | Nemysis Ltd | Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases |
| US20230338545A1 (en) * | 2020-09-17 | 2023-10-26 | Syracuse University | Complexes of magnesium maltol (3-hydroxy-2-methyl-4h-pyran-4-one) for oral supplementation |
| AU2022323733A1 (en) | 2021-08-03 | 2024-02-29 | Pharmacosmos Holding A/S | Iron complex compounds for subcutaneous use in therapy of iron deficiency in companion animals |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2826147A1 (de) * | 1977-06-20 | 1978-12-21 | Mooney Chemicals | Metallorganische zusammensetzungen bzw. verbindungen und verfahren zu ihrer herstellung |
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| US2575347A (en) * | 1949-07-14 | 1951-11-20 | Interchem Corp | Metallo organic compounds |
| GB959282A (en) * | 1959-08-19 | 1964-05-27 | Hardman & Holden Ltd | Improvements relating to organic aluminium compounds |
| US3076798A (en) * | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| US3679377A (en) * | 1970-02-17 | 1972-07-25 | Union Oil Co | Iron complexes containing aquo,sulfate and hydroxyl ligands |
| US3821192A (en) * | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| US4137359A (en) * | 1977-10-31 | 1979-01-30 | Mooney Chemicals, Inc. | Elastomers with improved metal adhesion |
| DE4239442C2 (de) * | 1992-11-24 | 2001-09-13 | Sebo Gmbh | Verwendung eines mit polynuklearen Metalloxidhydroxiden modifizierten Adsorptionsmaterials zur selektiven Elimination von anorganischem Phosphat aus proteinhaltigen Flüssigkeiten |
| US6177581B1 (en) | 1999-10-12 | 2001-01-23 | The Dow Chemical Company | Mixed-metal chelates and process for the preparation thereof |
| US20030049284A1 (en) * | 2001-09-05 | 2003-03-13 | Boccio Jose Ruben | Method of increasing the solubility of alphahydrocarboxilic salts, and products obtained by the method |
| ES2357293T3 (es) | 2001-10-08 | 2011-04-25 | Purac Biochem N.V. | Método de preparación de gluconato de calcio. |
| EP1476399B1 (en) * | 2002-01-24 | 2007-03-28 | William Marsh Rice University | Organic acid-feooh (ferroxane) particles and ferroxane-derived ceramics and ceramic membranes |
| US7994217B2 (en) | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
| DE10249552A1 (de) * | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US6706904B1 (en) | 2002-12-04 | 2004-03-16 | Albion International, Inc. | Dimetalhydroxy malates |
| TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| US7674780B2 (en) * | 2004-03-16 | 2010-03-09 | Navinta Llc | Iron sucrose complexes and method of manufacture thereof |
| WO2005094203A2 (en) * | 2004-03-16 | 2005-10-13 | Navinta, Llc | Sodium ferric gluconate complexes and method of manufacture thereof |
| BRPI0515847A (pt) | 2004-10-08 | 2008-08-12 | Unilever Nv | uso de um complexo de ferro, composição alimentìcia, gênero alimentìcio fortificado com ferro, composição de bebida, bebida fortificada com ferro, suplemento alimentar e composição farmacêutica |
| DE202005014332U1 (de) | 2005-09-09 | 2006-01-19 | Institut für Oberflächenmodifizierung e.V. | Metallorganisches Nanopulver |
| KR101514470B1 (ko) | 2007-02-06 | 2015-04-22 | 메디칼 리서취 카운실 | 리간드 개질 폴리 옥소-히드록시 금속 이온 물질, 이의 용도 및 이의 제조 방법 |
| TWI592159B (zh) | 2007-11-16 | 2017-07-21 | 威佛（國際）股份有限公司 | 藥學組成物 |
| GB0814326D0 (en) * | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
-
2008
- 2008-02-06 KR KR1020097016904A patent/KR101514470B1/ko active Active
- 2008-02-06 PL PL08709331T patent/PL2125847T3/pl unknown
- 2008-02-06 US US12/026,861 patent/US8058462B2/en active Active
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- 2008-02-06 HR HRP20150944TT patent/HRP20150944T1/hr unknown
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2826147A1 (de) * | 1977-06-20 | 1978-12-21 | Mooney Chemicals | Metallorganische zusammensetzungen bzw. verbindungen und verfahren zu ihrer herstellung |
Non-Patent Citations (2)
| Title |
|---|
| HOLLEMAN A. F. ET AL.: "Lehrbuch der Anorganischen Chemie", LEHRBUCH DER ANORGANISCHEN CHEMIE, BERLIN: WALTER DE GRUYTER, DE, 1976, pages 930-931, XP002482484, page 931 * |
| HOLLEMANN A. F. ET AL.: "Lehrbuch der Anorganischen Chemie", LEHRBUCH DER ANORGANISCHEN CHEMIE, BERLIN: WALTER DE GRUYTER, DE, 1 January 1995 (1995-01-01), page 929, XP002350463, ISBN: 978-3-11-012641-9 * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL199901A0 (en) | 2010-04-15 |
| US20080188555A1 (en) | 2008-08-07 |
| US8058462B2 (en) | 2011-11-15 |
| GB2451713A (en) | 2009-02-11 |
| JP5756598B2 (ja) | 2015-07-29 |
| CA2676146A1 (en) | 2008-08-14 |
| HRP20150944T1 (hr) | 2015-10-09 |
| EP2125847B1 (en) | 2015-06-17 |
| GB2451713B (en) | 2009-12-16 |
| BRPI0807212B1 (pt) | 2022-01-11 |
| KR101514470B1 (ko) | 2015-04-22 |
| AU2008212653A1 (en) | 2008-08-14 |
| EA200970718A1 (ru) | 2010-02-26 |
| PL2125847T3 (pl) | 2015-12-31 |
| AU2008212653B2 (en) | 2012-05-24 |
| GB0802214D0 (en) | 2008-03-12 |
| EP2125847A1 (en) | 2009-12-02 |
| BRPI0807212A2 (pt) | 2014-06-17 |
| WO2008096130A1 (en) | 2008-08-14 |
| CY1116590T1 (el) | 2017-03-15 |
| JP2010520856A (ja) | 2010-06-17 |
| IL199901A (en) | 2014-11-30 |
| CA2676146C (en) | 2016-08-09 |
| KR20090121281A (ko) | 2009-11-25 |
| MX2009008281A (es) | 2009-08-25 |
| HK1138598A1 (en) | 2010-08-27 |
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