EA018559B1 - Система доставки лекарственного средства для введения водорастворимого катионного и амфифильного фармацевтически активного вещества - Google Patents
Система доставки лекарственного средства для введения водорастворимого катионного и амфифильного фармацевтически активного вещества Download PDFInfo
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- EA018559B1 EA018559B1 EA201070626A EA201070626A EA018559B1 EA 018559 B1 EA018559 B1 EA 018559B1 EA 201070626 A EA201070626 A EA 201070626A EA 201070626 A EA201070626 A EA 201070626A EA 018559 B1 EA018559 B1 EA 018559B1
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- Eurasian Patent Office
- Prior art keywords
- methyl ester
- drug delivery
- delivery system
- sodium salt
- complex
- Prior art date
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- 238000006467 substitution reaction Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
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- 201000008827 tuberculosis Diseases 0.000 description 1
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- 229960004355 vindesine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SE2007/001128 WO2009078755A1 (en) | 2007-12-19 | 2007-12-19 | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| PCT/SE2008/051517 WO2009078804A1 (en) | 2007-12-19 | 2008-12-18 | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201070626A1 EA201070626A1 (ru) | 2010-12-30 |
| EA018559B1 true EA018559B1 (ru) | 2013-08-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA201070626A EA018559B1 (ru) | 2007-12-19 | 2008-12-18 | Система доставки лекарственного средства для введения водорастворимого катионного и амфифильного фармацевтически активного вещества |
Country Status (23)
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| EP (1) | EP2231193B1 (enExample) |
| JP (1) | JP5466174B2 (enExample) |
| KR (1) | KR101616135B1 (enExample) |
| CN (1) | CN101945671B (enExample) |
| AU (1) | AU2008339101B2 (enExample) |
| BR (1) | BRPI0821739B8 (enExample) |
| CA (1) | CA2709268C (enExample) |
| CY (1) | CY1121145T1 (enExample) |
| DK (1) | DK2231193T3 (enExample) |
| EA (1) | EA018559B1 (enExample) |
| ES (1) | ES2689509T3 (enExample) |
| HR (1) | HRP20181517T1 (enExample) |
| HU (1) | HUE039695T2 (enExample) |
| LT (1) | LT2231193T (enExample) |
| MX (1) | MX2010006906A (enExample) |
| MY (1) | MY150820A (enExample) |
| NZ (1) | NZ586858A (enExample) |
| PL (1) | PL2231193T3 (enExample) |
| PT (1) | PT2231193T (enExample) |
| SI (1) | SI2231193T1 (enExample) |
| WO (2) | WO2009078755A1 (enExample) |
| ZA (1) | ZA201004992B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009078756A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| WO2009078754A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of poorly water soluble pharmaceutically active substances |
| CN112239418B (zh) * | 2019-07-18 | 2023-07-07 | 上海现代药物制剂工程研究中心有限公司 | 视黄醇类化合物及其钠盐的制备方法 |
| CN112321465B (zh) | 2019-07-18 | 2023-06-06 | 上海现代药物制剂工程研究中心有限公司 | 一种含苯基化合物、其中间体、制备方法及应用 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197809B1 (en) * | 1998-12-23 | 2001-03-06 | Ardenia Investments Ltd. | Compounds for the treatment of cancer |
| WO2002092600A1 (en) * | 2001-05-15 | 2002-11-21 | Ardenia Investments Ltd. | Retinol derivatives potentiation of active substances by micellar preparation |
| US20040048923A1 (en) * | 2002-07-23 | 2004-03-11 | Oleg Strelchenok | Therapeutic compounds |
| WO2005089106A2 (en) * | 2004-02-27 | 2005-09-29 | Molecular Therapeutics, Inc. | Degradable nanoparticles |
| EP1666031A1 (en) * | 2003-09-04 | 2006-06-07 | NanoCarrier Co., Ltd. | Composition containing nanoparticles containing water-soluble basic drug encapsulated therein |
| WO2006106519A2 (en) * | 2005-04-07 | 2006-10-12 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds |
| WO2007001356A2 (en) * | 2004-09-10 | 2007-01-04 | University Of Wyoming | Nanoparticles for cytoplasmic drug delivery to cancer cells |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU766256B2 (en) * | 1999-03-11 | 2003-10-09 | Ardenia Investments Ltd. | New compounds for the treatment of cancer |
| US6656504B1 (en) | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
| KR100566911B1 (ko) * | 2001-06-25 | 2006-04-03 | 주식회사 삼양사 | 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체 |
| US20050191359A1 (en) * | 2001-09-28 | 2005-09-01 | Solubest Ltd. | Water soluble nanoparticles and method for their production |
| JP2004010479A (ja) * | 2002-06-03 | 2004-01-15 | Japan Science & Technology Corp | ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法 |
| SI2301531T1 (sl) * | 2005-02-18 | 2018-11-30 | Abraxis Bioscience, Llc | Kombinacije in načini dajanja terapevtskih sredstev in kombinacijska terapija |
| CA2620389C (en) * | 2005-08-31 | 2014-06-17 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
| WO2009078756A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| WO2009078754A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of poorly water soluble pharmaceutically active substances |
-
2007
- 2007-12-19 WO PCT/SE2007/001128 patent/WO2009078755A1/en not_active Ceased
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2008
- 2008-12-18 PT PT08863195T patent/PT2231193T/pt unknown
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- 2008-12-18 US US12/809,265 patent/US8324274B2/en active Active
- 2008-12-18 BR BRPI0821739A patent/BRPI0821739B8/pt not_active IP Right Cessation
- 2008-12-18 CN CN2008801270941A patent/CN101945671B/zh not_active Expired - Fee Related
- 2008-12-18 EP EP08863195.7A patent/EP2231193B1/en active Active
- 2008-12-18 AU AU2008339101A patent/AU2008339101B2/en not_active Ceased
- 2008-12-18 CA CA2709268A patent/CA2709268C/en active Active
- 2008-12-18 NZ NZ586858A patent/NZ586858A/en not_active IP Right Cessation
- 2008-12-18 KR KR1020107015634A patent/KR101616135B1/ko active Active
- 2008-12-18 MX MX2010006906A patent/MX2010006906A/es active IP Right Grant
- 2008-12-18 JP JP2010539387A patent/JP5466174B2/ja not_active Expired - Fee Related
- 2008-12-18 HR HRP20181517TT patent/HRP20181517T1/hr unknown
- 2008-12-18 PL PL08863195T patent/PL2231193T3/pl unknown
- 2008-12-18 MY MYPI20102785 patent/MY150820A/en unknown
- 2008-12-18 WO PCT/SE2008/051517 patent/WO2009078804A1/en not_active Ceased
- 2008-12-18 SI SI200831998T patent/SI2231193T1/sl unknown
- 2008-12-18 ES ES08863195.7T patent/ES2689509T3/es active Active
- 2008-12-18 EA EA201070626A patent/EA018559B1/ru unknown
- 2008-12-18 HU HUE08863195A patent/HUE039695T2/hu unknown
- 2008-12-18 DK DK08863195.7T patent/DK2231193T3/en active
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2010
- 2010-07-14 ZA ZA2010/04992A patent/ZA201004992B/en unknown
-
2018
- 2018-10-03 CY CY20181101023T patent/CY1121145T1/el unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197809B1 (en) * | 1998-12-23 | 2001-03-06 | Ardenia Investments Ltd. | Compounds for the treatment of cancer |
| WO2002092600A1 (en) * | 2001-05-15 | 2002-11-21 | Ardenia Investments Ltd. | Retinol derivatives potentiation of active substances by micellar preparation |
| US20040048923A1 (en) * | 2002-07-23 | 2004-03-11 | Oleg Strelchenok | Therapeutic compounds |
| EP1666031A1 (en) * | 2003-09-04 | 2006-06-07 | NanoCarrier Co., Ltd. | Composition containing nanoparticles containing water-soluble basic drug encapsulated therein |
| WO2005089106A2 (en) * | 2004-02-27 | 2005-09-29 | Molecular Therapeutics, Inc. | Degradable nanoparticles |
| WO2007001356A2 (en) * | 2004-09-10 | 2007-01-04 | University Of Wyoming | Nanoparticles for cytoplasmic drug delivery to cancer cells |
| WO2006106519A2 (en) * | 2005-04-07 | 2006-10-12 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds |
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| CHAVANPATIL, MAHESH et al., "Polymer-Surfactant Nanoparticles for Sustained Release of Water-Soluble Drugs", Journal of pharmaceutical sciences, December 2007, vol. 96, No. 12, p. 3379-389 * |
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