EA017915B1 - Kcnq-открыватели калиевых каналов, применяемые для лечения или ослабления симптомов шизофрении - Google Patents
Kcnq-открыватели калиевых каналов, применяемые для лечения или ослабления симптомов шизофрении Download PDFInfo
- Publication number
- EA017915B1 EA017915B1 EA200870232A EA200870232A EA017915B1 EA 017915 B1 EA017915 B1 EA 017915B1 EA 200870232 A EA200870232 A EA 200870232A EA 200870232 A EA200870232 A EA 200870232A EA 017915 B1 EA017915 B1 EA 017915B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- morpholin
- dimethyl
- schizophrenia
- ylphenyl
- symptoms
- Prior art date
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77130406P | 2006-02-07 | 2006-02-07 | |
| DKPA200600175 | 2006-02-07 | ||
| PCT/DK2007/050013 WO2007090409A1 (en) | 2006-02-07 | 2007-02-02 | Use of kcnq-openers for threating or reducing the symptoms of schizophrenia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200870232A1 EA200870232A1 (ru) | 2009-02-27 |
| EA017915B1 true EA017915B1 (ru) | 2013-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA200870232A EA017915B1 (ru) | 2006-02-07 | 2007-02-02 | Kcnq-открыватели калиевых каналов, применяемые для лечения или ослабления симптомов шизофрении |
Country Status (16)
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| US (1) | US20090118285A1 (enExample) |
| EP (2) | EP2554162A1 (enExample) |
| JP (1) | JP2009525993A (enExample) |
| KR (1) | KR20080096659A (enExample) |
| CN (1) | CN101378742B (enExample) |
| AR (1) | AR059319A1 (enExample) |
| AU (1) | AU2007214128B2 (enExample) |
| BR (1) | BRPI0707495A2 (enExample) |
| CA (1) | CA2641564C (enExample) |
| EA (1) | EA017915B1 (enExample) |
| IL (1) | IL192745A0 (enExample) |
| MX (1) | MX2008009655A (enExample) |
| NO (1) | NO20083838L (enExample) |
| NZ (1) | NZ569517A (enExample) |
| TW (1) | TWI453013B (enExample) |
| WO (1) | WO2007090409A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011513196A (ja) * | 2007-08-01 | 2011-04-28 | ハー・ルンドベック・アクチエゼルスカベット | ドーパミン作動系が破壊された障害もしくは状態の症状を軽減するためまたはその障害もしくは状態を処置するためのｋｃｎｑカリウムチャネル開口薬の使用 |
| CA2804165C (en) | 2010-07-08 | 2015-02-24 | Pfizer Inc. | Piperidinyl pyrimidine amides as kv7 potassium channel openers |
| WO2016077724A1 (en) * | 2014-11-13 | 2016-05-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | (2-amino-4(arylamino)phenyl) carbamates |
| US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| MA51881B1 (fr) | 2018-02-20 | 2023-08-31 | H Lundbeck As | Dérivés d'alcool utilisés en tant qu'agents d'ouverture du canal potassique kv7 |
| WO2019203951A1 (en) | 2018-04-20 | 2019-10-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Selective potassium channel agonists |
| RS66130B1 (sr) | 2019-08-02 | 2024-11-29 | H Lundbeck As | Derivati alkohola kao otvarači kv7 kalijumovih kanala |
| CN119490430A (zh) | 2019-08-02 | 2025-02-21 | H.隆德贝克有限公司 | 用于在癫痫或癫痫发作中使用的作为Kv7钾通道开放剂的醇衍生物 |
| AR119521A1 (es) | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| US20230015539A1 (en) * | 2019-12-06 | 2023-01-19 | Icahn School Of Medicine At Mount Sinai | Method of treatment with kcnq channel openers |
Citations (6)
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|---|---|---|---|---|
| WO2002062295A2 (en) * | 2001-02-02 | 2002-08-15 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| US20040106621A1 (en) * | 2002-11-22 | 2004-06-03 | Yong-Jin Wu | 3-Heterocyclic benzylamide derivatives as potassium channel openers |
| WO2004060880A1 (en) * | 2002-12-20 | 2004-07-22 | Bristol-Myers Squibb Company | Aminoalkyl thiazole derivatives as kcnq modulators |
| WO2004080950A1 (en) * | 2003-03-14 | 2004-09-23 | H. Lundbeck A/S | Substituted aniline derivatives |
| WO2005025293A2 (en) * | 2003-09-10 | 2005-03-24 | Icagen, Inc. | Fused ring heterocycles as potassium channel modulators |
| WO2005087754A1 (en) * | 2004-03-12 | 2005-09-22 | H. Lundbeck A/S | Substituted morpholine and thiomorpholine derivatives |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4200259A1 (de) * | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| JP4294142B2 (ja) | 1999-02-02 | 2009-07-08 | 株式会社日立製作所 | ディスクサブシステム |
| GB9915414D0 (en) * | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
| US6472165B1 (en) * | 1999-08-03 | 2002-10-29 | Arzneimittelwerk Dresden Gmbh | Modulatory binding site in potassium channels for screening and finding new active ingredients |
| CA2438868A1 (en) * | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| US6469042B1 (en) * | 2001-02-20 | 2002-10-22 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators if KCNQ potassium channels |
| JP2004535413A (ja) * | 2001-05-31 | 2004-11-25 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャンネルモジュレーターとしてのシンナミド誘導体 |
| DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
| NZ540446A (en) * | 2002-12-27 | 2008-03-28 | Lundbeck & Co As H | 1,2,4-Triaminobenzene derivatives useful for treating disorders of the central nervous system |
| EP1603858A2 (en) * | 2003-03-11 | 2005-12-14 | NeuroSearch A/S | Kcnq channel modulating compounds and their pharmaceutical use |
| AU2004222626B2 (en) * | 2003-03-21 | 2010-06-24 | H. Lundbeck A/S | Substituted p-diaminobenzene derivatives |
| EP1631546A1 (en) | 2003-04-25 | 2006-03-08 | H. Lundbeck A/S | Sustituted indoline and indole derivatives |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| ATE423128T1 (de) * | 2004-02-20 | 2009-03-15 | Nat Ct For Biolog Sciences | Neues kaliumkanalmodulierendes peptid |
| WO2006000020A1 (en) | 2004-06-29 | 2006-01-05 | European Nickel Plc | Improved leaching of base metals |
| UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| US7812020B2 (en) * | 2005-03-03 | 2010-10-12 | H. Lundbeck A/S | Substituted pyridine derivatives |
| WO2007063418A2 (en) * | 2005-04-13 | 2007-06-07 | Neuraxon, Inc. | Substituted indole compounds having nos inhibitory activity |
-
2007
- 2007-02-02 EP EP12190206A patent/EP2554162A1/en not_active Withdrawn
- 2007-02-02 EP EP07702527A patent/EP1983974A1/en not_active Withdrawn
- 2007-02-02 BR BRPI0707495-6A patent/BRPI0707495A2/pt not_active IP Right Cessation
- 2007-02-02 JP JP2008553621A patent/JP2009525993A/ja not_active Ceased
- 2007-02-02 CA CA2641564A patent/CA2641564C/en not_active Expired - Fee Related
- 2007-02-02 KR KR1020087019396A patent/KR20080096659A/ko not_active Ceased
- 2007-02-02 AU AU2007214128A patent/AU2007214128B2/en not_active Ceased
- 2007-02-02 TW TW096103826A patent/TWI453013B/zh not_active IP Right Cessation
- 2007-02-02 CN CN2007800046484A patent/CN101378742B/zh not_active Expired - Fee Related
- 2007-02-02 EA EA200870232A patent/EA017915B1/ru not_active IP Right Cessation
- 2007-02-02 WO PCT/DK2007/050013 patent/WO2007090409A1/en not_active Ceased
- 2007-02-02 MX MX2008009655A patent/MX2008009655A/es active IP Right Grant
- 2007-02-02 NZ NZ569517A patent/NZ569517A/en not_active IP Right Cessation
- 2007-02-02 US US12/278,394 patent/US20090118285A1/en not_active Abandoned
- 2007-02-05 AR ARP070100469A patent/AR059319A1/es not_active Application Discontinuation
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2008
- 2008-07-10 IL IL192745A patent/IL192745A0/en unknown
- 2008-09-05 NO NO20083838A patent/NO20083838L/no not_active Application Discontinuation
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| WO2002062295A2 (en) * | 2001-02-02 | 2002-08-15 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| US20040106621A1 (en) * | 2002-11-22 | 2004-06-03 | Yong-Jin Wu | 3-Heterocyclic benzylamide derivatives as potassium channel openers |
| WO2004060880A1 (en) * | 2002-12-20 | 2004-07-22 | Bristol-Myers Squibb Company | Aminoalkyl thiazole derivatives as kcnq modulators |
| WO2004080950A1 (en) * | 2003-03-14 | 2004-09-23 | H. Lundbeck A/S | Substituted aniline derivatives |
| WO2005025293A2 (en) * | 2003-09-10 | 2005-03-24 | Icagen, Inc. | Fused ring heterocycles as potassium channel modulators |
| WO2005087754A1 (en) * | 2004-03-12 | 2005-09-22 | H. Lundbeck A/S | Substituted morpholine and thiomorpholine derivatives |
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| HANSEN, H.H. ET AL.: "The KCNQ Channel Opener Retigabine Inhibits the Activity of Mesencephalic Dopaminergic Systems of the Rat". THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 318, no. 3, September 2006 (2006-09), pages 1006-1019, XP009084511, USA, the whole document, abstract, page 1018, right-hand column, last paragraph * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2554162A1 (en) | 2013-02-06 |
| AR059319A1 (es) | 2008-03-26 |
| EA200870232A1 (ru) | 2009-02-27 |
| IL192745A0 (en) | 2009-02-11 |
| AU2007214128B2 (en) | 2012-05-17 |
| JP2009525993A (ja) | 2009-07-16 |
| CN101378742B (zh) | 2013-07-10 |
| NZ569517A (en) | 2011-07-29 |
| CN101378742A (zh) | 2009-03-04 |
| MX2008009655A (es) | 2008-09-03 |
| CA2641564C (en) | 2012-06-12 |
| TWI453013B (zh) | 2014-09-21 |
| US20090118285A1 (en) | 2009-05-07 |
| KR20080096659A (ko) | 2008-10-31 |
| TW200808296A (en) | 2008-02-16 |
| NO20083838L (no) | 2008-10-31 |
| BRPI0707495A2 (pt) | 2011-05-03 |
| EP1983974A1 (en) | 2008-10-29 |
| CA2641564A1 (en) | 2007-08-16 |
| AU2007214128A1 (en) | 2007-08-16 |
| WO2007090409A1 (en) | 2007-08-16 |
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