EA017668B1 - Производные 6н-дибензо[b,e]оксепина в качестве нестероидных антагонистов минералокортикоидных рецепторов - Google Patents

Производные 6н-дибензо[b,e]оксепина в качестве нестероидных антагонистов минералокортикоидных рецепторов Download PDF

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Publication number
EA017668B1
EA017668B1 EA201070762A EA201070762A EA017668B1 EA 017668 B1 EA017668 B1 EA 017668B1 EA 201070762 A EA201070762 A EA 201070762A EA 201070762 A EA201070762 A EA 201070762A EA 017668 B1 EA017668 B1 EA 017668B1
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EA
Eurasian Patent Office
Prior art keywords
compound
mol
formula
hours
dibenzo
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EA201070762A
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English (en)
Russian (ru)
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EA201070762A1 (ru
Inventor
Константинос Гавардинас
Прабхакар Кондаджи Джадхав
Original Assignee
Эли Лилли Энд Компани
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Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201070762A1 publication Critical patent/EA201070762A1/ru
Publication of EA017668B1 publication Critical patent/EA017668B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201070762A 2007-12-19 2008-12-09 Производные 6н-дибензо[b,e]оксепина в качестве нестероидных антагонистов минералокортикоидных рецепторов EA017668B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1477607P 2007-12-19 2007-12-19
PCT/US2008/085997 WO2009085584A1 (en) 2007-12-19 2008-12-09 6h-dibenz0 [b, e] oxepine derived nonsteroidal mineralocorticoid receptor antagonists

Publications (2)

Publication Number Publication Date
EA201070762A1 EA201070762A1 (ru) 2010-12-30
EA017668B1 true EA017668B1 (ru) 2013-02-28

Family

ID=40430143

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070762A EA017668B1 (ru) 2007-12-19 2008-12-09 Производные 6н-дибензо[b,e]оксепина в качестве нестероидных антагонистов минералокортикоидных рецепторов

Country Status (33)

Country Link
US (1) US7994164B2 (OSRAM)
EP (2) EP2235007B1 (OSRAM)
JP (1) JP5562866B2 (OSRAM)
KR (1) KR101254382B1 (OSRAM)
CN (1) CN101903377B (OSRAM)
AR (1) AR069554A1 (OSRAM)
AU (1) AU2008343524B2 (OSRAM)
BR (1) BRPI0820805A2 (OSRAM)
CA (1) CA2710409C (OSRAM)
CL (1) CL2008003600A1 (OSRAM)
CO (1) CO6300953A2 (OSRAM)
DK (1) DK2235007T3 (OSRAM)
DO (1) DOP2010000185A (OSRAM)
EA (1) EA017668B1 (OSRAM)
EC (2) ECSP10010266A (OSRAM)
ES (2) ES2459318T3 (OSRAM)
GT (1) GT201000179A (OSRAM)
HR (1) HRP20120916T1 (OSRAM)
IL (1) IL206353A (OSRAM)
MA (1) MA31910B1 (OSRAM)
MX (1) MX2010006911A (OSRAM)
MY (1) MY150474A (OSRAM)
NZ (1) NZ586300A (OSRAM)
PE (1) PE20091057A1 (OSRAM)
PL (1) PL2235007T3 (OSRAM)
PT (1) PT2235007E (OSRAM)
RS (1) RS52594B (OSRAM)
SI (1) SI2235007T1 (OSRAM)
TN (1) TN2010000292A1 (OSRAM)
TW (1) TWI431010B (OSRAM)
UA (1) UA100131C2 (OSRAM)
WO (1) WO2009085584A1 (OSRAM)
ZA (1) ZA201004257B (OSRAM)

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US8242140B2 (en) 2007-08-03 2012-08-14 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
BRPI0821342A2 (pt) 2007-12-19 2019-09-24 Boehringer Ingelheim Int inibidores da polimerase viral
AU2010222902B2 (en) * 2009-03-12 2013-04-18 Eli Lilly And Company Mineralocorticoid receptor antagonist and methods of use
US8957052B2 (en) 2010-05-10 2015-02-17 Universite Paris Descartes Methods and compositions for the treatment of fluid accumulation in and/or under the retina
WO2011157798A1 (en) 2010-06-16 2011-12-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for stimulating reepithelialisation during wound healing
CN102060670A (zh) * 2011-01-04 2011-05-18 常州大学 一种2-溴-6-氟苯甲醇的制备方法
UA111696C2 (uk) 2013-05-02 2016-05-25 Пфайзер Інк. Похідні імідазотриазину як інгібітори рde10
AR099416A1 (es) 2014-02-28 2016-07-20 Lilly Co Eli Terapia combinada para la hipertensión resistente
CA2953655C (en) 2014-06-30 2020-05-12 Astrazeneca Ab Benzoxazinone amides as mineralocorticoid receptor modulators
US20170246166A1 (en) * 2014-11-21 2017-08-31 Eli Lilly And Company 1,2-benzothiazole compounds for the treatment of kidney disorders
EP3362095B1 (en) 2015-10-13 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
US20190262363A1 (en) 2016-07-26 2019-08-29 INSERM (Institut National de la Santé et de la Recherche Médicale Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
UA123464C2 (uk) * 2016-09-24 2021-04-07 Кейбіпі Байосайєнсіз Ко., Лтд. Фармацевтична композиція, яка містить антагоніст мінералокортикоїдних рецепторів, та її застосування
JP7697961B2 (ja) 2020-03-11 2025-06-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 対象が中心性漿液性脈絡網膜症を有するか、または有する危険性があるかどうかを決定する方法。
US20240366632A1 (en) 2021-08-31 2024-11-07 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of ocular rosacea

Citations (2)

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EP0345747A2 (en) * 1988-06-09 1989-12-13 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
WO2004052847A2 (en) * 2002-06-26 2004-06-24 Eli Lilly And Company Tricyclic steroid hormone nuclear receptor modulators

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US4072756A (en) 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
SE426341C (sv) * 1980-02-14 1985-09-23 Fagersta Ab Sett att forhindra korrosion i en forbrenningsanleggnings kylare och skorsten vid kylning av rokgaser
FR2603713B1 (fr) 1986-09-10 1992-07-24 Canon Kk Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant
GB8914061D0 (en) 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
US5378701A (en) 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
ZA9811898B (en) 1997-12-29 2000-06-28 Ortho Mcneil Pharm Inc Anti-Inflammatory Compounds.
EP1154997A4 (en) 1999-01-26 2002-11-04 Dana Farber Cancer Inst Inc PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE
ATE320431T1 (de) * 2001-11-21 2006-04-15 Millennium Pharm Inc Chemokine rezeptor antagonisten und methoden zu deren anwendung
US7803814B2 (en) * 2003-12-19 2010-09-28 Eli Lilly And Company Tricyclic steroid hormone nuclear receptor modulators
WO2005066153A1 (en) 2003-12-19 2005-07-21 Eli Lilly And Company Tricyclic steroid hormone nuclear receptor modulators
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
JP2008508314A (ja) 2004-07-28 2008-03-21 アイアールエム・リミテッド・ライアビリティ・カンパニー ステロイドホルモン核内受容体のモジュレーターとしての化合物および組成物
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BRPI0717937A2 (pt) 2006-10-31 2013-12-03 Pfizer Prod Inc Compostos de pirazona como antagonistas do receptor mineralocorticóide
JP2010522732A (ja) 2007-03-29 2010-07-08 ナームローゼ・フエンノートチヤツプ・オルガノン 鉱質コルチコイド受容体アンタゴニスト
GB0725102D0 (en) 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
PE20091339A1 (es) 2007-12-21 2009-09-26 Glaxo Group Ltd Derivados de oxadiazol con actividad sobre receptores s1p1
US20100292233A1 (en) 2008-01-25 2010-11-18 Arena Pharmaceuticals, Inc. Dihydro-1h-pyrrolo[1,2-a]indol-1-yl carboxylic acid derivatives which act as s1p1 agonists
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Publication number Priority date Publication date Assignee Title
EP0345747A2 (en) * 1988-06-09 1989-12-13 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
WO2004052847A2 (en) * 2002-06-26 2004-06-24 Eli Lilly And Company Tricyclic steroid hormone nuclear receptor modulators

Also Published As

Publication number Publication date
ZA201004257B (en) 2011-11-30
EP2537845B1 (en) 2014-03-19
DOP2010000185A (es) 2010-09-15
TN2010000292A1 (en) 2011-11-11
KR101254382B1 (ko) 2013-04-15
JP2011507868A (ja) 2011-03-10
RS52594B (sr) 2013-04-30
EP2235007A1 (en) 2010-10-06
EP2235007B1 (en) 2012-10-31
PL2235007T3 (pl) 2013-03-29
DK2235007T3 (da) 2012-12-17
US7994164B2 (en) 2011-08-09
CA2710409C (en) 2012-11-06
AR069554A1 (es) 2010-02-03
TW200930721A (en) 2009-07-16
MY150474A (en) 2014-01-30
ES2396605T3 (es) 2013-02-22
WO2009085584A1 (en) 2009-07-09
JP5562866B2 (ja) 2014-07-30
AU2008343524A1 (en) 2009-07-09
CA2710409A1 (en) 2009-07-09
CL2008003600A1 (es) 2010-02-19
HK1144284A1 (en) 2011-02-11
EP2537845A1 (en) 2012-12-26
EA201070762A1 (ru) 2010-12-30
US20090163472A1 (en) 2009-06-25
CN101903377A (zh) 2010-12-01
GT201000179A (es) 2012-04-16
MA31910B1 (fr) 2010-12-01
ES2459318T3 (es) 2014-05-09
NZ586300A (en) 2012-06-29
KR20100082866A (ko) 2010-07-20
ECSP10010266A (es) 2010-07-30
CN101903377B (zh) 2014-07-09
TWI431010B (zh) 2014-03-21
SI2235007T1 (sl) 2013-01-31
BRPI0820805A2 (pt) 2015-06-16
IL206353A0 (en) 2010-12-30
PT2235007E (pt) 2013-01-22
AU2008343524B2 (en) 2012-03-08
CO6300953A2 (es) 2011-07-21
MX2010006911A (es) 2010-10-05
IL206353A (en) 2014-06-30
ECSP12012048A (es) 2012-08-31
PE20091057A1 (es) 2009-07-20
HRP20120916T1 (hr) 2012-12-31
UA100131C2 (uk) 2012-11-26

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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