EA017393B1 - Производные тиадиазинона - Google Patents
Производные тиадиазинона Download PDFInfo
- Publication number
- EA017393B1 EA017393B1 EA201000364A EA201000364A EA017393B1 EA 017393 B1 EA017393 B1 EA 017393B1 EA 201000364 A EA201000364 A EA 201000364A EA 201000364 A EA201000364 A EA 201000364A EA 017393 B1 EA017393 B1 EA 017393B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- formula
- thiadiazin
- benzyl
- dihydro
- Prior art date
Links
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- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 6
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 5
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 5
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 5
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical compound [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 claims description 5
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- FSJFVFSTLDWHNZ-UHFFFAOYSA-N 5-(3,5-difluorophenyl)-3-[[3-[5-[3-(dimethylamino)propoxy]pyrimidin-2-yl]phenyl]methyl]-6h-1,3,4-thiadiazin-2-one Chemical compound N1=CC(OCCCN(C)C)=CN=C1C1=CC=CC(CN2C(SCC(=N2)C=2C=C(F)C=C(F)C=2)=O)=C1 FSJFVFSTLDWHNZ-UHFFFAOYSA-N 0.000 claims description 2
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- WTVXIBRMWGUIMI-UHFFFAOYSA-N trifluoro($l^{1}-oxidanylsulfonyl)methane Chemical group [O]S(=O)(=O)C(F)(F)F WTVXIBRMWGUIMI-UHFFFAOYSA-N 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- KPZYAGQLBFUTMA-UHFFFAOYSA-K tripotassium;phosphate;trihydrate Chemical compound O.O.O.[K+].[K+].[K+].[O-]P([O-])([O-])=O KPZYAGQLBFUTMA-UHFFFAOYSA-K 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007041115A DE102007041115A1 (de) | 2007-08-30 | 2007-08-30 | Thiadiazinonderivate |
| PCT/EP2008/006466 WO2009030333A1 (de) | 2007-08-30 | 2008-08-06 | Thiadiazinonderivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201000364A1 EA201000364A1 (ru) | 2010-08-30 |
| EA017393B1 true EA017393B1 (ru) | 2012-12-28 |
Family
ID=39952448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201000364A EA017393B1 (ru) | 2007-08-30 | 2008-08-06 | Производные тиадиазинона |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8211886B2 (enExample) |
| EP (1) | EP2181111B1 (enExample) |
| JP (1) | JP5524840B2 (enExample) |
| KR (1) | KR20100065171A (enExample) |
| CN (1) | CN101784544B (enExample) |
| AR (1) | AR068130A1 (enExample) |
| AU (1) | AU2008295193B2 (enExample) |
| BR (1) | BRPI0816058A2 (enExample) |
| CA (1) | CA2698062C (enExample) |
| DE (1) | DE102007041115A1 (enExample) |
| EA (1) | EA017393B1 (enExample) |
| ES (1) | ES2426356T3 (enExample) |
| IL (1) | IL204127A (enExample) |
| MX (1) | MX2010002096A (enExample) |
| WO (1) | WO2009030333A1 (enExample) |
| ZA (1) | ZA201002218B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012003338A1 (en) | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| US10398774B2 (en) | 2014-12-09 | 2019-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against AXL |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0618201A1 (de) * | 1993-04-01 | 1994-10-05 | MERCK PATENT GmbH | Thiadiazinone und ihre verwendung zur Bekämpfung von Cardiovaskulären sowie asthmatischen erkrankkungen |
| WO2007057093A1 (de) * | 2005-11-21 | 2007-05-24 | Merck Patent Gmbh | 3, 6-dihydro-2-oxo-6h-(1,3,4)thiadiazinderivate |
| WO2007057092A1 (de) * | 2005-11-21 | 2007-05-24 | Merck Patent Gmbh | Substituierte 5-phenyl-3,6-dihydro-2-oxo-6h-[1,3,4]thiadiazine |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5795964A (en) | 1980-12-04 | 1982-06-15 | Morishita Seiyaku Kk | Preparation of 2-substituted-3(2h)-pyridazinone derivative |
| US4397854A (en) | 1981-05-14 | 1983-08-09 | Warner-Lambert Company | Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents |
| AU691673B2 (en) | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
| US5635494A (en) | 1995-04-21 | 1997-06-03 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| DE19604388A1 (de) | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | Arylalkyl-diazinone |
| PL194689B1 (pl) | 1996-02-13 | 2007-06-29 | Astrazeneca Uk Ltd | Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania |
| EP0885198B1 (en) | 1996-03-05 | 2001-12-19 | AstraZeneca AB | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| RU2209813C2 (ru) | 1997-11-19 | 2003-08-10 | Кова Ко., Лтд. | Производные пиридазина, лекарственные средства на их основе и способ лечения артрита |
| TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| EP1289952A1 (en) | 2000-05-31 | 2003-03-12 | AstraZeneca AB | Indole derivatives with vascular damaging activity |
| WO2002008213A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| CN1255391C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管破坏剂的colchinol衍生物 |
| CN1578665A (zh) | 2001-10-31 | 2005-02-09 | 默克专利股份公司 | 4型磷酸二脂酶抑制剂及其应用 |
| DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
| DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
-
2007
- 2007-08-30 DE DE102007041115A patent/DE102007041115A1/de not_active Withdrawn
-
2008
- 2008-08-06 WO PCT/EP2008/006466 patent/WO2009030333A1/de not_active Ceased
- 2008-08-06 JP JP2010522210A patent/JP5524840B2/ja not_active Expired - Fee Related
- 2008-08-06 CA CA2698062A patent/CA2698062C/en active Active
- 2008-08-06 US US12/675,412 patent/US8211886B2/en not_active Expired - Fee Related
- 2008-08-06 AU AU2008295193A patent/AU2008295193B2/en not_active Ceased
- 2008-08-06 CN CN2008801040992A patent/CN101784544B/zh not_active Expired - Fee Related
- 2008-08-06 KR KR1020107006823A patent/KR20100065171A/ko not_active Withdrawn
- 2008-08-06 MX MX2010002096A patent/MX2010002096A/es active IP Right Grant
- 2008-08-06 EP EP08785386.7A patent/EP2181111B1/de active Active
- 2008-08-06 ES ES08785386T patent/ES2426356T3/es active Active
- 2008-08-06 EA EA201000364A patent/EA017393B1/ru not_active IP Right Cessation
- 2008-08-06 BR BRPI0816058 patent/BRPI0816058A2/pt not_active IP Right Cessation
- 2008-08-29 AR ARP080103757A patent/AR068130A1/es unknown
-
2010
- 2010-02-23 IL IL204127A patent/IL204127A/en active IP Right Grant
- 2010-03-29 ZA ZA2010/02218A patent/ZA201002218B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0618201A1 (de) * | 1993-04-01 | 1994-10-05 | MERCK PATENT GmbH | Thiadiazinone und ihre verwendung zur Bekämpfung von Cardiovaskulären sowie asthmatischen erkrankkungen |
| WO2007057093A1 (de) * | 2005-11-21 | 2007-05-24 | Merck Patent Gmbh | 3, 6-dihydro-2-oxo-6h-(1,3,4)thiadiazinderivate |
| WO2007057092A1 (de) * | 2005-11-21 | 2007-05-24 | Merck Patent Gmbh | Substituierte 5-phenyl-3,6-dihydro-2-oxo-6h-[1,3,4]thiadiazine |
Non-Patent Citations (1)
| Title |
|---|
| CUI J.J.: "Inhibitors targeting hepatocyte growth factor receptor and their potential therapeutic applications", EXPERT OPINION ON THERAPEUTIC PATENTS, 2007, GB, vol. 17, no. 9, 1 September 2007 (2007-09-01), pages 1035-1045, XP002502367, the whole document * |
Also Published As
| Publication number | Publication date |
|---|---|
| AR068130A1 (es) | 2009-11-04 |
| CA2698062C (en) | 2016-05-31 |
| CN101784544A (zh) | 2010-07-21 |
| JP2010536896A (ja) | 2010-12-02 |
| HK1146276A1 (en) | 2011-05-20 |
| JP5524840B2 (ja) | 2014-06-18 |
| BRPI0816058A2 (pt) | 2015-03-31 |
| KR20100065171A (ko) | 2010-06-15 |
| ZA201002218B (en) | 2010-12-29 |
| IL204127A (en) | 2013-08-29 |
| US8211886B2 (en) | 2012-07-03 |
| CN101784544B (zh) | 2012-08-29 |
| US20100311733A1 (en) | 2010-12-09 |
| EA201000364A1 (ru) | 2010-08-30 |
| DE102007041115A1 (de) | 2009-03-05 |
| WO2009030333A1 (de) | 2009-03-12 |
| CA2698062A1 (en) | 2009-03-12 |
| EP2181111B1 (de) | 2013-06-26 |
| ES2426356T3 (es) | 2013-10-22 |
| AU2008295193B2 (en) | 2013-04-18 |
| MX2010002096A (es) | 2010-03-26 |
| EP2181111A1 (de) | 2010-05-05 |
| AU2008295193A1 (en) | 2009-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |