EA017297B1 - Некоторые производные 2-пиразинона и их применение в качестве ингибиторов нейтрофильной эластазы - Google Patents
Некоторые производные 2-пиразинона и их применение в качестве ингибиторов нейтрофильной эластазы Download PDFInfo
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- EA017297B1 EA017297B1 EA201000702A EA201000702A EA017297B1 EA 017297 B1 EA017297 B1 EA 017297B1 EA 201000702 A EA201000702 A EA 201000702A EA 201000702 A EA201000702 A EA 201000702A EA 017297 B1 EA017297 B1 EA 017297B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- trifluoromethyl
- phenyl
- oxo
- methyl
- carboxamide
- Prior art date
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98571307P | 2007-11-06 | 2007-11-06 | |
| PCT/SE2008/051263 WO2009061271A1 (en) | 2007-11-06 | 2008-11-05 | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
Publications (2)
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| EA201000702A1 EA201000702A1 (ru) | 2010-12-30 |
| EA017297B1 true EA017297B1 (ru) | 2012-11-30 |
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| EA201000702A EA017297B1 (ru) | 2007-11-06 | 2008-11-05 | Некоторые производные 2-пиразинона и их применение в качестве ингибиторов нейтрофильной эластазы |
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| Country | Link |
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| US (1) | US8466284B2 (https=) |
| EP (1) | EP2217591A4 (https=) |
| JP (1) | JP2011502982A (https=) |
| KR (1) | KR20100096131A (https=) |
| CN (1) | CN101918391B (https=) |
| AR (1) | AR069206A1 (https=) |
| AU (1) | AU2008325288B2 (https=) |
| BR (1) | BRPI0819258A2 (https=) |
| CA (1) | CA2703996A1 (https=) |
| CL (1) | CL2008003301A1 (https=) |
| CO (1) | CO6270241A2 (https=) |
| CR (1) | CR11416A (https=) |
| DO (1) | DOP2010000134A (https=) |
| EA (1) | EA017297B1 (https=) |
| IL (1) | IL205209A0 (https=) |
| MX (1) | MX2010004673A (https=) |
| NI (1) | NI201000079A (https=) |
| PE (1) | PE20091565A1 (https=) |
| SV (1) | SV2010003559A (https=) |
| TW (1) | TW200924770A (https=) |
| UY (1) | UY31456A1 (https=) |
| WO (1) | WO2009061271A1 (https=) |
| ZA (1) | ZA201002853B (https=) |
Families Citing this family (20)
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| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| WO2009061271A1 (en) | 2007-11-06 | 2009-05-14 | Astrazeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| CA2773618A1 (en) | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| US20110224229A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Novel Crystalline Form |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| TW201247631A (en) | 2011-04-28 | 2012-12-01 | Du Pont | Herbicidal pyrazinones |
| RU2638537C2 (ru) * | 2012-07-12 | 2017-12-14 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Ингибирование ферментов |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| WO2016134459A1 (en) | 2015-02-23 | 2016-09-01 | The Royal Institution For The Advancement Of Learning/Mcgill University | Method for the preparation of metal-organic compounds |
| CN104788355A (zh) * | 2015-04-02 | 2015-07-22 | 聊城大学 | 一种含氮杂环苯腈或邻苯二腈化合物的合成方法 |
| CR20200176A (es) * | 2017-10-24 | 2020-07-24 | Bayer Pharma AG | Profármacos de derivados de triazol sustituido y sus usos |
| CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
| WO2021209740A1 (en) | 2020-04-16 | 2021-10-21 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating coronavirus infection |
| EP4419102A1 (en) | 2021-10-20 | 2024-08-28 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
| CN117398373A (zh) * | 2022-07-07 | 2024-01-16 | 上海汇伦医药股份有限公司 | 西维来司他的新用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005026123A1 (en) * | 2003-09-18 | 2005-03-24 | Astrazeneca Ab | 2-pyridone derivatives as neutrophil elastase inhibitors and their use |
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- 2008-11-05 CL CL2008003301A patent/CL2008003301A1/es unknown
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| WO2005026123A1 (en) * | 2003-09-18 | 2005-03-24 | Astrazeneca Ab | 2-pyridone derivatives as neutrophil elastase inhibitors and their use |
| WO2006098683A1 (en) * | 2005-03-16 | 2006-09-21 | Astrazeneca Ab | 2-pyridine derivatives as inhibitors of neutrophile elastase |
| WO2007129963A1 (en) * | 2006-05-08 | 2007-11-15 | Astrazeneca Ab | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Also Published As
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|---|---|
| DOP2010000134A (es) | 2010-10-15 |
| AR069206A1 (es) | 2010-01-06 |
| EP2217591A4 (en) | 2011-10-26 |
| UY31456A1 (es) | 2009-07-17 |
| US20100280048A1 (en) | 2010-11-04 |
| CA2703996A1 (en) | 2009-05-14 |
| CN101918391A (zh) | 2010-12-15 |
| CN101918391B (zh) | 2013-06-05 |
| PE20091565A1 (es) | 2009-11-06 |
| TW200924770A (en) | 2009-06-16 |
| IL205209A0 (en) | 2010-12-30 |
| WO2009061271A1 (en) | 2009-05-14 |
| BRPI0819258A2 (pt) | 2017-05-02 |
| SV2010003559A (es) | 2010-09-13 |
| AU2008325288B2 (en) | 2011-12-22 |
| CL2008003301A1 (es) | 2009-10-16 |
| CR11416A (es) | 2010-08-27 |
| AU2008325288A1 (en) | 2009-05-14 |
| ZA201002853B (en) | 2011-10-26 |
| CO6270241A2 (es) | 2011-04-20 |
| EA201000702A1 (ru) | 2010-12-30 |
| EP2217591A1 (en) | 2010-08-18 |
| MX2010004673A (es) | 2010-05-27 |
| JP2011502982A (ja) | 2011-01-27 |
| NI201000079A (es) | 2011-03-24 |
| KR20100096131A (ko) | 2010-09-01 |
| US8466284B2 (en) | 2013-06-18 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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