CN101918391B - 一些2-吡嗪酮衍生物和它们在制备嗜中性白细胞弹性蛋白酶抑制剂中的用途 - Google Patents

一些2-吡嗪酮衍生物和它们在制备嗜中性白细胞弹性蛋白酶抑制剂中的用途 Download PDF

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CN101918391B
CN101918391B CN2008801241402A CN200880124140A CN101918391B CN 101918391 B CN101918391 B CN 101918391B CN 2008801241402 A CN2008801241402 A CN 2008801241402A CN 200880124140 A CN200880124140 A CN 200880124140A CN 101918391 B CN101918391 B CN 101918391B
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phenyl
methyl
oxo
trifluoromethyl
compound
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CN101918391A (zh
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德布拉·安格
戴维·查普曼
马丁·琳德斯乔
汉斯·洛恩
迈克尔·伦德克维斯特
马格努斯·芒克阿夫罗森舍尔德
安东尼奥斯·尼基提迪斯
约翰·帕维
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
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  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2008801241402A 2007-11-06 2008-11-05 一些2-吡嗪酮衍生物和它们在制备嗜中性白细胞弹性蛋白酶抑制剂中的用途 Expired - Fee Related CN101918391B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98571307P 2007-11-06 2007-11-06
US60/985,713 2007-11-06
PCT/SE2008/051263 WO2009061271A1 (en) 2007-11-06 2008-11-05 Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase

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CN101918391A CN101918391A (zh) 2010-12-15
CN101918391B true CN101918391B (zh) 2013-06-05

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CN2008801241402A Expired - Fee Related CN101918391B (zh) 2007-11-06 2008-11-05 一些2-吡嗪酮衍生物和它们在制备嗜中性白细胞弹性蛋白酶抑制剂中的用途

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US (1) US8466284B2 (https=)
EP (1) EP2217591A4 (https=)
JP (1) JP2011502982A (https=)
KR (1) KR20100096131A (https=)
CN (1) CN101918391B (https=)
AR (1) AR069206A1 (https=)
AU (1) AU2008325288B2 (https=)
BR (1) BRPI0819258A2 (https=)
CA (1) CA2703996A1 (https=)
CL (1) CL2008003301A1 (https=)
CO (1) CO6270241A2 (https=)
CR (1) CR11416A (https=)
DO (1) DOP2010000134A (https=)
EA (1) EA017297B1 (https=)
IL (1) IL205209A0 (https=)
MX (1) MX2010004673A (https=)
NI (1) NI201000079A (https=)
PE (1) PE20091565A1 (https=)
SV (1) SV2010003559A (https=)
TW (1) TW200924770A (https=)
UY (1) UY31456A1 (https=)
WO (1) WO2009061271A1 (https=)
ZA (1) ZA201002853B (https=)

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TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
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US9102624B2 (en) 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057920A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
EP3262029A4 (en) 2015-02-23 2018-10-17 The Royal Institution for the Advancement of Learning / McGill University Method for the preparation of metal-organic compounds
CN104788355A (zh) * 2015-04-02 2015-07-22 聊城大学 一种含氮杂环苯腈或邻苯二腈化合物的合成方法
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JP7672641B2 (ja) 2019-09-17 2025-05-08 メレオ バイオファーマ ４ リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
IL297211B2 (en) 2020-04-16 2025-12-01 Mereo Biopharma 4 Ltd Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
KR20240090272A (ko) 2021-10-20 2024-06-21 메레오 바이오파마 4 리미티드 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제
CN117398373A (zh) * 2022-07-07 2024-01-16 上海汇伦医药股份有限公司 西维来司他的新用途

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KR20100096131A (ko) 2010-09-01
CO6270241A2 (es) 2011-04-20
AU2008325288B2 (en) 2011-12-22
EP2217591A1 (en) 2010-08-18
PE20091565A1 (es) 2009-11-06
CN101918391A (zh) 2010-12-15
EA201000702A1 (ru) 2010-12-30
TW200924770A (en) 2009-06-16
WO2009061271A1 (en) 2009-05-14
EA017297B1 (ru) 2012-11-30
US8466284B2 (en) 2013-06-18
CR11416A (es) 2010-08-27
AR069206A1 (es) 2010-01-06
CA2703996A1 (en) 2009-05-14
CL2008003301A1 (es) 2009-10-16
JP2011502982A (ja) 2011-01-27
SV2010003559A (es) 2010-09-13
NI201000079A (es) 2011-03-24
AU2008325288A1 (en) 2009-05-14
US20100280048A1 (en) 2010-11-04
EP2217591A4 (en) 2011-10-26
ZA201002853B (en) 2011-10-26
DOP2010000134A (es) 2010-10-15
MX2010004673A (es) 2010-05-27
UY31456A1 (es) 2009-07-17
IL205209A0 (en) 2010-12-30
BRPI0819258A2 (pt) 2017-05-02

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