EA017187B1 - Конденсированные производные тиазола в качестве ингибиторов киназ - Google Patents

Конденсированные производные тиазола в качестве ингибиторов киназ Download PDF

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Publication number
EA017187B1
EA017187B1 EA201000038A EA201000038A EA017187B1 EA 017187 B1 EA017187 B1 EA 017187B1 EA 201000038 A EA201000038 A EA 201000038A EA 201000038 A EA201000038 A EA 201000038A EA 017187 B1 EA017187 B1 EA 017187B1
Authority
EA
Eurasian Patent Office
Prior art keywords
methyl
dimethyl
thiazolo
pyridin
oxo
Prior art date
Application number
EA201000038A
Other languages
English (en)
Russian (ru)
Other versions
EA201000038A1 (ru
Inventor
Рикки Питер Александер
Павандип Сингх Ауджла
Карен-Вивьян-Люсиль Крепи
Анне Мари Фоли
Ричард Джереми Франклин
Original Assignee
Юсб Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0612644A external-priority patent/GB0612644D0/en
Priority claimed from GB0620062A external-priority patent/GB0620062D0/en
Application filed by Юсб Фарма С.А. filed Critical Юсб Фарма С.А.
Priority claimed from PCT/GB2008/002194 external-priority patent/WO2009001089A1/fr
Publication of EA201000038A1 publication Critical patent/EA201000038A1/ru
Publication of EA017187B1 publication Critical patent/EA017187B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA201000038A 2006-06-26 2008-06-24 Конденсированные производные тиазола в качестве ингибиторов киназ EA017187B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0612644A GB0612644D0 (en) 2006-06-26 2006-06-26 Therapeutic agents
GB0620062A GB0620062D0 (en) 2006-10-10 2006-10-10 Therapeutic agents
PCT/GB2007/002390 WO2008001076A1 (fr) 2006-06-26 2007-06-26 Dérivés de thiazole à cycle fusionnés en tant qu'inhibiteurs de kinase
PCT/GB2008/002194 WO2009001089A1 (fr) 2007-06-26 2008-06-24 Dérivés de thiazole fusionné comme inhibiteurs de kinase

Publications (2)

Publication Number Publication Date
EA201000038A1 EA201000038A1 (ru) 2010-06-30
EA017187B1 true EA017187B1 (ru) 2012-10-30

Family

ID=38671000

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000038A EA017187B1 (ru) 2006-06-26 2008-06-24 Конденсированные производные тиазола в качестве ингибиторов киназ

Country Status (20)

Country Link
US (3) US8242116B2 (fr)
EP (2) EP2035436B1 (fr)
CN (1) CN101687885B (fr)
AT (1) ATE510840T1 (fr)
AU (1) AU2008269577B2 (fr)
CA (1) CA2692085C (fr)
CO (1) CO6270229A2 (fr)
CY (1) CY1114419T1 (fr)
DK (1) DK2170906T3 (fr)
EA (1) EA017187B1 (fr)
ES (2) ES2365258T3 (fr)
HR (1) HRP20130523T1 (fr)
IL (1) IL202659A0 (fr)
ME (1) ME01592B (fr)
MX (1) MX2009013740A (fr)
MY (1) MY148852A (fr)
PL (1) PL2170906T3 (fr)
PT (1) PT2170906E (fr)
RS (1) RS52824B (fr)
WO (1) WO2008001076A1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009071890A1 (fr) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Inhibiteurs tricycliques de kinase
WO2009071895A1 (fr) * 2007-12-04 2009-06-11 Ucb Pharma S.A. Dérivés thiazole et thiophène fusionnés comme inhibiteurs de kinase
CN101945867A (zh) 2007-12-19 2011-01-12 安姆根有限公司 作为细胞周期抑制剂的稠合吡啶、嘧啶和三嗪化合物
MX2010010975A (es) 2008-04-07 2010-11-01 Amgen Inc Amino piridinas/pirimidinas gem-disustituidas y espirociclicas como inhibidores de ciclo celular.
JPWO2009130900A1 (ja) * 2008-04-24 2011-08-11 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
US8603945B2 (en) * 2008-07-23 2013-12-10 The Regents Of The University Of California Methods and compositions for providing salicyclic acid-independent pathogen resistance in plants
EP2341052A4 (fr) * 2008-09-05 2011-10-12 Shionogi & Co Derive de morpholine à cycles condensés ayant une activite inhibitrice de pi3k
MX2011008645A (es) 2009-02-17 2011-09-30 Vertex Pharma Inhibidores de tetrahidrotiazolopiridina de fosfatidilinositol 3 cinasa.
AU2010226826A1 (en) * 2009-03-18 2011-10-13 Merck Sharp & Dohme Corp. Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
UY32582A (es) * 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
EP2432321B1 (fr) * 2009-05-20 2017-06-14 Glaxosmithkline LLC Dérivés de thiazolopyrimidinone comme inhibiteurs de la kinase pi3
GB0912946D0 (en) 2009-07-24 2009-09-02 Addex Pharmaceuticals Sa New compounds 5
ES2534326T3 (es) 2009-08-20 2015-04-21 Karus Therapeutics Limited Compuestos tricíclicos heterocíclicos como inhibidores de la fosfoinositida 3-cinasa
EA019980B1 (ru) 2009-12-18 2014-07-30 Янссен Фармацевтика Нв БИЦИКЛИЧЕСКИЕ ТИАЗОЛЫ В КАЧЕСТВЕ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR5
ES2437166T3 (es) * 2009-12-18 2014-01-09 Janssen Pharmaceutica, N.V. Tiazoles bicíclicos como moduladores alostéricos de receptores mGluR5
CN103068820A (zh) 2010-06-15 2013-04-24 拜耳知识产权有限责任公司 新的邻位取代的芳基酰胺衍生物
AR084486A1 (es) 2010-10-01 2013-05-22 Basf Se Compuestos de imina
UY33671A (es) * 2010-10-13 2012-04-30 Millenium Pharmaceuticals Inc Heteroarilos y sus usos
CN103328485A (zh) * 2010-11-24 2013-09-25 埃克塞里艾克西斯公司 作为mTOR抑制剂的苯并氧氮杂卓及其使用和生产方法
CN102649777B (zh) * 2011-02-25 2014-03-12 中国中化股份有限公司 一种制备1-芳基-3-羧基-5-吡唑啉酮类化合物的方法
DK2937349T3 (en) 2011-03-23 2017-02-20 Amgen Inc CONDENSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3
PL2794600T3 (pl) 2011-12-22 2018-06-29 Novartis Ag Pochodne 2,3-dihydro-benzo[1,4]oksazyny i powiązane związki jako inhibitory kinazy fosfoinozytydu-3 (PI3K) do leczenia np. reumatoidalnego zapalenia stawów
EP2970135B1 (fr) 2013-03-14 2018-07-18 Epizyme, Inc. Derives de pyrazol comme des inhibiteurs de prmt1 et leur utilisation
WO2014178954A1 (fr) 2013-03-14 2014-11-06 Epizyme, Inc. Inhibiteurs de l'arginine méthyltransférase et utilisations de ceux-ci
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
AU2014236146B2 (en) 2013-03-14 2018-05-17 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EP2970133B1 (fr) 2013-03-14 2018-10-24 Epizyme, Inc. Dérivés de pyrazole en tant qu'inhibiteurs de prmt1 et leurs utilisations
US9365527B2 (en) 2013-03-14 2016-06-14 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9133189B2 (en) 2013-03-14 2015-09-15 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9765035B2 (en) 2013-03-14 2017-09-19 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2014153090A1 (fr) 2013-03-14 2014-09-25 Epizyme, Inc. Dérivés de pyrazole en tant qu'inhibiteurs de prmt1 et leurs utilisations
US9045455B2 (en) 2013-03-14 2015-06-02 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
KR102325919B1 (ko) * 2013-10-21 2021-11-12 우미코레 아게 운트 코 카게 방향족 아민의 모노아릴화
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
WO2017156350A1 (fr) 2016-03-09 2017-09-14 K-Gen, Inc. Méthodes de traitement du cancer
CN108570043A (zh) * 2018-06-20 2018-09-25 王延娇 一种化合物及其作为选择性pi3k抑制剂在治疗肿瘤中的应用
EP3849548A1 (fr) 2018-09-13 2021-07-21 Stemline Therapeutics Inc. Méthodes de traitement de la myopathie centronucléaire
BR112021010453A2 (pt) 2018-12-19 2021-08-24 Leo Pharma A/S Composto, e, composição farmacêutica
AU2020207089A1 (en) * 2019-01-08 2021-06-24 Kyorin Pharmaceutical Co., Ltd. 15-PGDH inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006114606A1 (fr) * 2005-04-26 2006-11-02 Ucb Pharma S.A. Derives de thiazole fusionne en tant qu'inhibiteurs de la kinase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006114606A1 (fr) * 2005-04-26 2006-11-02 Ucb Pharma S.A. Derives de thiazole fusionne en tant qu'inhibiteurs de la kinase

Also Published As

Publication number Publication date
CY1114419T1 (el) 2016-08-31
PT2170906E (pt) 2013-06-25
US20100137302A1 (en) 2010-06-03
US20110003785A1 (en) 2011-01-06
EP2170906B1 (fr) 2013-04-03
CA2692085A1 (fr) 2008-12-31
CO6270229A2 (es) 2011-04-20
AU2008269577B2 (en) 2012-12-20
EP2170906A1 (fr) 2010-04-07
IL202659A0 (en) 2010-06-30
ES2365258T3 (es) 2011-09-27
ATE510840T1 (de) 2011-06-15
CN101687885A (zh) 2010-03-31
AU2008269577A1 (en) 2008-12-31
US8338592B2 (en) 2012-12-25
ES2416364T3 (es) 2013-07-31
HRP20130523T1 (en) 2013-07-31
RS52824B (fr) 2013-10-31
CN101687885B (zh) 2012-08-22
EA201000038A1 (ru) 2010-06-30
US8242116B2 (en) 2012-08-14
DK2170906T3 (da) 2013-06-24
WO2008001076A1 (fr) 2008-01-03
EP2035436B1 (fr) 2011-05-25
PL2170906T3 (pl) 2013-08-30
MX2009013740A (es) 2010-02-01
MY148852A (en) 2013-06-14
US20130079330A1 (en) 2013-03-28
EP2035436A1 (fr) 2009-03-18
ME01592B (me) 2014-09-20
CA2692085C (fr) 2015-10-13
US8710054B2 (en) 2014-04-29

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG MD TJ TM