EA016731B1 - Изоформа человеческой альфа-енолазы, антитело к указанной изоформе и способы их применения - Google Patents

Изоформа человеческой альфа-енолазы, антитело к указанной изоформе и способы их применения Download PDF

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Publication number
EA016731B1
EA016731B1 EA200970332A EA200970332A EA016731B1 EA 016731 B1 EA016731 B1 EA 016731B1 EA 200970332 A EA200970332 A EA 200970332A EA 200970332 A EA200970332 A EA 200970332A EA 016731 B1 EA016731 B1 EA 016731B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
isoforms
ενοα
proteins
patients
Prior art date
Application number
EA200970332A
Other languages
English (en)
Russian (ru)
Other versions
EA200970332A1 (ru
Inventor
Франческо Новелли
Барбара Томаино
Паола Каппелло
Original Assignee
Рибовакс Байотекнолоджиз Са
Биолине Дианьостичи Срл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рибовакс Байотекнолоджиз Са, Биолине Дианьостичи Срл filed Critical Рибовакс Байотекнолоджиз Са
Publication of EA200970332A1 publication Critical patent/EA200970332A1/ru
Publication of EA016731B1 publication Critical patent/EA016731B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • G01N33/57525—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
    • G01N33/575—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
EA200970332A 2006-09-29 2007-09-28 Изоформа человеческой альфа-енолазы, антитело к указанной изоформе и способы их применения EA016731B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06121552 2006-09-29
EP06126726 2006-12-20
PCT/EP2007/060305 WO2008037792A1 (en) 2006-09-29 2007-09-28 Novel antigens and antibodies associated to pancreatic ductal adenocarcinoma

Publications (2)

Publication Number Publication Date
EA200970332A1 EA200970332A1 (ru) 2009-10-30
EA016731B1 true EA016731B1 (ru) 2012-07-30

Family

ID=38895810

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970332A EA016731B1 (ru) 2006-09-29 2007-09-28 Изоформа человеческой альфа-енолазы, антитело к указанной изоформе и способы их применения

Country Status (18)

Country Link
US (1) US8071721B2 (enExample)
EP (1) EP2069395B1 (enExample)
JP (1) JP2010505104A (enExample)
KR (1) KR20090094227A (enExample)
CN (1) CN101578295B (enExample)
AT (1) ATE542831T1 (enExample)
AU (1) AU2007301966B2 (enExample)
BR (1) BRPI0717282A2 (enExample)
CA (1) CA2664841A1 (enExample)
DK (1) DK2069395T3 (enExample)
EA (1) EA016731B1 (enExample)
ES (1) ES2381304T3 (enExample)
IL (2) IL197868A (enExample)
NO (1) NO20091662L (enExample)
NZ (1) NZ576409A (enExample)
PL (1) PL2069395T3 (enExample)
PT (1) PT2069395E (enExample)
WO (1) WO2008037792A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009137832A2 (en) * 2008-05-09 2009-11-12 Duke University Autoantibodies in the detection and treatment of cancer
IT1398782B1 (it) * 2009-09-11 2013-03-18 Novelli Peptide monofosforilato isolato derivato dall'alfa-enolasi umana utile per la diagnosi e il trattamento dell'adenocarcinoma pancreatico, anticorpi diretti contro il suddetto peptide monofosforilato e loro usi.
ITTO20120523A1 (it) * 2012-06-15 2013-12-16 Natimab Therapeutics S R L Procedimento e kit per la diagnosi in vitro dell'adenocarcinoma duttale pancreatico o per determinare la predisposizione all'adenocarcinoma duttale pancreatico
EP3083697B1 (en) * 2013-12-20 2019-04-17 Development Center for Biotechnology Alpha-enolase specific antibodies and methods of uses in cancer therapy
WO2015106296A1 (en) 2014-01-13 2015-07-16 Berg Llc Enolse 1 (eno1) compositions and uses thereof
CN115786317A (zh) * 2022-12-12 2023-03-14 江苏三联生物工程股份有限公司 重组神经元特异性烯醇化酶及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753446A (en) * 1993-04-15 1998-05-19 National Jewish Center For Immunology & Respiratory Medicine Mitogen ERK kinase kinase (MEKK) assay

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GIALLONGO A. ET AL.: "MOLECULAR CLONING AND NUCLEOTIDE SEQUENCE OF A FULL-LENGTH COMPLEMENTARY DNA FOR HUMAN ALPHA ENOLASE". PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 83, no. 18, 1986, pages 6741-6745, XP002464441, ISSN: 0027-8424 *
MARCUS K. ET AL.: "IDENTIFICATION OF PLATELET PROTEINS SEPARATED BY TWO-DIMENSIONAL GEL ELECTROPHORESIS AND ANALYZED BY MATRIX ASSISTED LASER DESORPTION/IONIZATION-TIME OF FLIGHT-MASS SPECTROMETRY AND DETECTION OF TYROSINE-PHOSPHORYLATED PROTEINS". ELECTROPHORESIS, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 21, no. 13, July 2000 (2000-07), pages 2622-2636, XP001080220, ISSN: 0173-0835, table 1 *
SHEN JIANJUN ET AL.: "Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry". CANCER RESEARCH, vol. 64, no. 24, 15 December, 2004 (2004-12-15), pages 9018-9026, XP002464440, ISSN: 0008-5472 page 9022, left-hand column, paragraph 3; figure 3; table 1, page 9025, left-hand column, last paragraph *
SUBRAMANIAN ARUNA ET AL.: "Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene". JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 8, 25 February, 2000 (2000-02-25), pages 5958-5965, XP002464442, ISSN: 0021-9258 *
TANAKA MINORU ET AL.: "Chicken alpha-enolase by not beta-enolase has a Src-dependent tyrosine-phosphorylation site: cDNA cloning and nucleotide sequence analysis". JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY/OUP, TOKYO, JP, vol. 117, no. 3, 1995, pages 554-559, XP009094439, ISSN: 0021-924X, page 556, right-hand column, last paragraph; figure 4 *
WALTER M. ET AL.: "AUTOREACTIVE EPITOPES WITHIN THE HUMAN ALPHA-ENOLASE AND THEIR RECOGNITION BY SERA FROM PATIENTS WITH ENDOMETRIOSIS". JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 8, no. 6, 1995, pages 931-945, XP000911010, ISSN: 0896-8411 *

Also Published As

Publication number Publication date
AU2007301966B2 (en) 2013-02-21
ES2381304T3 (es) 2012-05-25
AU2007301966A1 (en) 2008-04-03
KR20090094227A (ko) 2009-09-04
WO2008037792A1 (en) 2008-04-03
IL218442A0 (en) 2012-04-30
IL197868A0 (en) 2011-08-01
EA200970332A1 (ru) 2009-10-30
CA2664841A1 (en) 2008-04-03
ATE542831T1 (de) 2012-02-15
PT2069395E (pt) 2012-04-27
US8071721B2 (en) 2011-12-06
NZ576409A (en) 2012-02-24
IL197868A (en) 2013-03-24
JP2010505104A (ja) 2010-02-18
US20100028907A1 (en) 2010-02-04
BRPI0717282A2 (pt) 2013-10-15
EP2069395A1 (en) 2009-06-17
CN101578295B (zh) 2013-02-27
NO20091662L (no) 2009-06-29
PL2069395T3 (pl) 2012-06-29
DK2069395T3 (da) 2012-05-14
EP2069395B1 (en) 2012-01-25
CN101578295A (zh) 2009-11-11

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU