EA016053B1 - Применение молекулы нуклеиновой кислоты, содержащей двухцепочечную область, для лечения пролиферативного нарушения - Google Patents

Применение молекулы нуклеиновой кислоты, содержащей двухцепочечную область, для лечения пролиферативного нарушения Download PDF

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Publication number
EA016053B1
EA016053B1 EA200900989A EA200900989A EA016053B1 EA 016053 B1 EA016053 B1 EA 016053B1 EA 200900989 A EA200900989 A EA 200900989A EA 200900989 A EA200900989 A EA 200900989A EA 016053 B1 EA016053 B1 EA 016053B1
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EA
Eurasian Patent Office
Prior art keywords
molecule
molecules
dna
use according
nucleic acid
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Application number
EA200900989A
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English (en)
Russian (ru)
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EA200900989A1 (ru
Inventor
Мари Дютри
Original Assignee
Сантр Насьональ Де Ля Решерш Сьентифик
Энститю Кюри
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Application filed by Сантр Насьональ Де Ля Решерш Сьентифик, Энститю Кюри filed Critical Сантр Насьональ Де Ля Решерш Сьентифик
Publication of EA200900989A1 publication Critical patent/EA200900989A1/ru
Publication of EA016053B1 publication Critical patent/EA016053B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EA200900989A 2007-01-12 2008-01-11 Применение молекулы нуклеиновой кислоты, содержащей двухцепочечную область, для лечения пролиферативного нарушения EA016053B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07300728A EP1944369A1 (en) 2007-01-12 2007-01-12 Dbait and its standalone uses thereof
PCT/EP2008/050265 WO2008084087A2 (en) 2007-01-12 2008-01-11 Dbait and its standalone uses thereof

Publications (2)

Publication Number Publication Date
EA200900989A1 EA200900989A1 (ru) 2009-12-30
EA016053B1 true EA016053B1 (ru) 2012-01-30

Family

ID=38515555

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900989A EA016053B1 (ru) 2007-01-12 2008-01-11 Применение молекулы нуклеиновой кислоты, содержащей двухцепочечную область, для лечения пролиферативного нарушения

Country Status (8)

Country Link
US (1) US8093366B2 (ja)
EP (2) EP1944369A1 (ja)
JP (1) JP5462632B2 (ja)
CN (1) CN101622351B (ja)
AU (1) AU2008204486C1 (ja)
CA (1) CA2673972C (ja)
EA (1) EA016053B1 (ja)
WO (1) WO2008084087A2 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA023927B1 (ru) 2010-06-22 2016-07-29 Дна Терапьютикс ОПТИМИЗИРОВАННАЯ С ПОМОЩЬЮ ЭНДОСОМОЛИТИЧЕСКИХ СРЕДСТВ СИСТЕМА ДОСТАВКИ in vivo КОНЪЮГАТОВ НУКЛЕИНОВОЙ КИСЛОТЫ
AU2015202211B2 (en) * 2010-06-22 2016-09-01 Centre National De La Recherche Scientifique Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
EP2527440A1 (en) 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
KR101896567B1 (ko) 2015-07-23 2018-09-07 인스티튜트 큐리 암 치료를 위한 디베이트 분자와 parp 억제제의 병용 용도
JP6949859B2 (ja) * 2016-03-01 2021-10-13 オンクセオＯｎｘｅｏ Ｄｂａｉｔ分子の全身投与によるガンの処置
WO2017186882A1 (en) * 2016-04-29 2017-11-02 Onxeo A method of predicting a response to an anti-tumor treatment by means of signal interfering dna molecules
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
US11629346B2 (en) * 2017-06-12 2023-04-18 University Of Miami Sting-dependent activators for treatment of disease
CN107793468A (zh) * 2017-06-26 2018-03-13 上海悦良生物科技有限公司 一种检测dna损伤的方法
EP3461488A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dbait molecule and a hdac inhibitor for treating cancer
CA3092779A1 (en) * 2018-03-13 2019-09-19 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
CN109321585B (zh) * 2018-09-30 2021-08-06 山东大学 一种利用t4脱氧核糖核酸连接酶提高原核微生物诱变育种效率的方法
US20220054524A1 (en) 2018-12-21 2022-02-24 Onxeo New conjugated nucleic acid molecules and their uses
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2021178295A1 (en) * 2020-03-03 2021-09-10 University Of Washington Synthetic agonists of dna-pk and their use
US11897888B1 (en) 2020-04-30 2024-02-13 Stinginn Llc Small molecular inhibitors of sting signaling compositions and methods of use
TW202210633A (zh) 2020-06-05 2022-03-16 法商昂席歐公司 用於治療癌症之dbait分子與kras抑制劑的組合
TW202214857A (zh) 2020-06-19 2022-04-16 法商昂席歐公司 新型結合核酸分子及其用途
WO2023111203A1 (en) 2021-12-16 2023-06-22 Onxeo New conjugated nucleic acid molecules and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005040378A1 (en) * 2003-10-24 2005-05-06 Institut Curie Nucleic acids useful for triggering tumor cell lethality

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005247807A (ja) * 2004-03-08 2005-09-15 Japan Science & Technology Agency Ｎｓａｉｄを利用した癌治療用組成物
US20060276423A1 (en) * 2005-04-18 2006-12-07 Rachel Altura Survivin-directed RNA interference-compositions and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005040378A1 (en) * 2003-10-24 2005-05-06 Institut Curie Nucleic acids useful for triggering tumor cell lethality

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI Z. ET AL.: "Targeting Ku protein for sensitizing of breast cancer cells to DNA damage" INTERNATIONAL JOURNAL OF MEDICINE, vol. 14, no. 2, August 2004 (2004-08), pages 153-159, XP008084143 the whole document *
YOO S. AND DYNAN W.S.: "Characterization of the RNA binding properties of Ku protein" BIOCHEMISTRY, vol. 37, 1998, pages 1336-1343, XP002452541 cited in the application the whole document *

Also Published As

Publication number Publication date
EP2102343B1 (en) 2015-07-08
JP5462632B2 (ja) 2014-04-02
AU2008204486C1 (en) 2013-05-16
CN101622351A (zh) 2010-01-06
EP1944369A1 (en) 2008-07-16
EP2102343A2 (en) 2009-09-23
JP2010515707A (ja) 2010-05-13
EA200900989A1 (ru) 2009-12-30
US20100022622A1 (en) 2010-01-28
CN101622351B (zh) 2014-05-14
CA2673972C (en) 2016-03-22
AU2008204486A1 (en) 2008-07-17
EP1944369A9 (en) 2008-10-15
AU2008204486B2 (en) 2012-11-29
WO2008084087A3 (en) 2009-01-08
US8093366B2 (en) 2012-01-10
WO2008084087A2 (en) 2008-07-17
CA2673972A1 (en) 2008-07-17

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