EA012285B1 - Композиция для ухода за контактными линзами - Google Patents
Композиция для ухода за контактными линзами Download PDFInfo
- Publication number
- EA012285B1 EA012285B1 EA200701776A EA200701776A EA012285B1 EA 012285 B1 EA012285 B1 EA 012285B1 EA 200701776 A EA200701776 A EA 200701776A EA 200701776 A EA200701776 A EA 200701776A EA 012285 B1 EA012285 B1 EA 012285B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- composition
- use according
- contact lenses
- miltefosine
- lenses
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 62
- PQLXHQMOHUQAKB-UHFFFAOYSA-N miltefosine Chemical compound CCCCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C PQLXHQMOHUQAKB-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229960003775 miltefosine Drugs 0.000 claims abstract description 26
- 239000000126 substance Substances 0.000 claims abstract description 12
- 108091005804 Peptidases Proteins 0.000 claims abstract description 5
- 239000004365 Protease Substances 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 23
- 239000000645 desinfectant Substances 0.000 claims description 10
- 238000004140 cleaning Methods 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- -1 alkali metal salts Chemical class 0.000 claims description 4
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- 239000012487 rinsing solution Substances 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
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- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 2
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- 229940123208 Biguanide Drugs 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
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- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical class CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 2
- 229950010221 alexidine Drugs 0.000 description 2
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- RXGSAYBOEDPICZ-UHFFFAOYSA-N 2-[6-[[amino-(diaminomethylideneamino)methylidene]amino]hexyl]-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)N RXGSAYBOEDPICZ-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- RFRMMZAKBNXNHE-UHFFFAOYSA-N 6-[4,6-dihydroxy-5-(2-hydroxyethoxy)-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)-5-(2-hydroxypropoxy)oxane-3,4-diol Chemical compound CC(O)COC1C(O)C(O)C(CO)OC1OC1C(O)C(OCCO)C(O)OC1CO RFRMMZAKBNXNHE-UHFFFAOYSA-N 0.000 description 1
- 206010069408 Acanthamoeba keratitis Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010011668 Cutaneous leishmaniasis Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
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- 102100036284 Hepcidin Human genes 0.000 description 1
- 101001021253 Homo sapiens Hepcidin Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
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- 206010037660 Pyrexia Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
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- 239000002671 adjuvant Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
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- 239000003899 bactericide agent Substances 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
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- 229960003260 chlorhexidine Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
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- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
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- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
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- 235000010981 methylcellulose Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229940023490 ophthalmic product Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
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- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001987 poloxamine Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- WTFXJFJYEJZMFO-UHFFFAOYSA-N propamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCOC1=CC=C(C(N)=N)C=C1 WTFXJFJYEJZMFO-UHFFFAOYSA-N 0.000 description 1
- 229960003761 propamidine Drugs 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- 230000009257 reactivity Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
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- 238000010186 staining Methods 0.000 description 1
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- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/10—Halogens or compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/364—Organic compounds containing phosphorus containing nitrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Eyeglasses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0030505A AT501545B1 (de) | 2005-02-23 | 2005-02-23 | Reinigungsmittel für kontaktlinsen |
| PCT/AT2006/000063 WO2006089320A1 (en) | 2005-02-23 | 2006-02-20 | Contact lens care composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200701776A1 EA200701776A1 (ru) | 2007-12-28 |
| EA012285B1 true EA012285B1 (ru) | 2009-08-28 |
Family
ID=36217244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200701776A EA012285B1 (ru) | 2005-02-23 | 2006-02-20 | Композиция для ухода за контактными линзами |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080300221A1 (https=) |
| EP (1) | EP1850888B1 (https=) |
| JP (1) | JP4738423B2 (https=) |
| CN (1) | CN101119755A (https=) |
| AT (2) | AT501545B1 (https=) |
| AU (1) | AU2006216085B2 (https=) |
| BR (1) | BRPI0606336A2 (https=) |
| CA (1) | CA2592246C (https=) |
| DE (1) | DE602006002806D1 (https=) |
| EA (1) | EA012285B1 (https=) |
| ES (1) | ES2313607T3 (https=) |
| PL (1) | PL1850888T3 (https=) |
| PT (1) | PT1850888E (https=) |
| WO (1) | WO2006089320A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100086512A1 (en) * | 2008-10-02 | 2010-04-08 | Rolf Schaefer | Mucomimetic compositions and uses therefore |
| US20130005819A1 (en) * | 2009-09-21 | 2013-01-03 | Brien Holden Vision Institute | Contact lens disinfecting solutions |
| WO2013135571A1 (en) | 2012-03-14 | 2013-09-19 | Orphanidis Pharma Research Gmbh | Compositions with enhanced therapeutic efficacy against infective agents of the eye comprising miltefosine and polyhexamethylene biguanide |
| WO2013154209A1 (en) * | 2012-04-12 | 2013-10-17 | Santen Pharmaceutical Co., Ltd. | Antiprotozoan composition containing caspofungin or its salt and biguanide compound or its salt |
| JP2015052505A (ja) * | 2013-09-06 | 2015-03-19 | 株式会社エイコー | アカントアメーバ（・シスト）の生死判別方法 |
| GB2594907B (en) * | 2019-08-15 | 2024-01-31 | Univ Of The West Of Scotland | Composition comprising anti-acanthamoeba agents |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0381617A2 (en) * | 1989-01-31 | 1990-08-08 | Ciba-Geigy Ag | Disinfecting and cleaning composition for contact lenses |
| DE4132345A1 (de) * | 1991-09-27 | 1993-04-01 | Max Planck Gesellschaft | Ether-lysolecithine und alkylphosphocholine in liposomen |
| WO1994016743A1 (en) * | 1993-01-26 | 1994-08-04 | Allergan, Inc. | Compositions and methods to disinfect contact lenses |
| EP0819968A1 (en) * | 1996-02-05 | 1998-01-21 | Tomey Technology Corporation | Disinfecting/washing composition for contact lenses and method for disinfecting and washing contact lenses by using the same |
| DE10203195A1 (de) * | 2002-01-25 | 2003-08-07 | Zentaris Ag | Verwendung von Alkylphosphocholinen in der Präventivbehandlung von Protozoenerkrankungen |
| DE10313272A1 (de) * | 2003-03-24 | 2004-10-21 | Baxter Healthcare S.A. | Verwendung von Miltefosine zur Behandlung von aktinischer oder multiplen aktinischer Keratosen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9606868D0 (en) * | 1996-04-01 | 1996-06-05 | Waverley Pharma Ltd | Disinfectant solutions |
| GB2333609B (en) * | 1998-01-27 | 2002-07-24 | Prof Alan Tomlinson | Salicylate inhibition of amoebic attachment to contact lenses |
| US20040063591A1 (en) * | 2002-09-30 | 2004-04-01 | Bausch & Lomb Incorporated | Compositions with enhanced antimicrobial efficacy against acanthamoebae |
-
2005
- 2005-02-23 AT AT0030505A patent/AT501545B1/de not_active IP Right Cessation
-
2006
- 2006-02-20 AT AT06704705T patent/ATE408427T1/de active
- 2006-02-20 AU AU2006216085A patent/AU2006216085B2/en not_active Ceased
- 2006-02-20 BR BRPI0606336-5A patent/BRPI0606336A2/pt active Search and Examination
- 2006-02-20 PT PT06704705T patent/PT1850888E/pt unknown
- 2006-02-20 US US11/817,011 patent/US20080300221A1/en not_active Abandoned
- 2006-02-20 ES ES06704705T patent/ES2313607T3/es not_active Expired - Lifetime
- 2006-02-20 EP EP06704705A patent/EP1850888B1/en not_active Expired - Lifetime
- 2006-02-20 DE DE602006002806T patent/DE602006002806D1/de not_active Expired - Lifetime
- 2006-02-20 PL PL06704705T patent/PL1850888T3/pl unknown
- 2006-02-20 WO PCT/AT2006/000063 patent/WO2006089320A1/en not_active Ceased
- 2006-02-20 JP JP2007556459A patent/JP4738423B2/ja not_active Expired - Fee Related
- 2006-02-20 CN CNA2006800052705A patent/CN101119755A/zh active Pending
- 2006-02-20 EA EA200701776A patent/EA012285B1/ru not_active IP Right Cessation
- 2006-02-20 CA CA2592246A patent/CA2592246C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0381617A2 (en) * | 1989-01-31 | 1990-08-08 | Ciba-Geigy Ag | Disinfecting and cleaning composition for contact lenses |
| DE4132345A1 (de) * | 1991-09-27 | 1993-04-01 | Max Planck Gesellschaft | Ether-lysolecithine und alkylphosphocholine in liposomen |
| WO1994016743A1 (en) * | 1993-01-26 | 1994-08-04 | Allergan, Inc. | Compositions and methods to disinfect contact lenses |
| EP0819968A1 (en) * | 1996-02-05 | 1998-01-21 | Tomey Technology Corporation | Disinfecting/washing composition for contact lenses and method for disinfecting and washing contact lenses by using the same |
| DE10203195A1 (de) * | 2002-01-25 | 2003-08-07 | Zentaris Ag | Verwendung von Alkylphosphocholinen in der Präventivbehandlung von Protozoenerkrankungen |
| DE10313272A1 (de) * | 2003-03-24 | 2004-10-21 | Baxter Healthcare S.A. | Verwendung von Miltefosine zur Behandlung von aktinischer oder multiplen aktinischer Keratosen |
Non-Patent Citations (1)
| Title |
|---|
| WALOCHNIK J. ET AL.: "CYTOTOXIC ACTIVITIES OF ALKYLPHOSPHOCHOLINES AGAINST CLINICAL ISOLATES OF ACANTHAMOEBA SPP", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 46, no. 3, March 2002 (2002-03), pages 695-701, XP001146164, ISSN: 0066-4804, cited in the application, the whole document * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2592246C (en) | 2013-01-08 |
| PT1850888E (pt) | 2008-11-20 |
| ATE408427T1 (de) | 2008-10-15 |
| JP2008532586A (ja) | 2008-08-21 |
| JP4738423B2 (ja) | 2011-08-03 |
| AT501545B1 (de) | 2007-10-15 |
| EA200701776A1 (ru) | 2007-12-28 |
| DE602006002806D1 (https=) | 2008-10-30 |
| BRPI0606336A2 (pt) | 2009-06-16 |
| CA2592246A1 (en) | 2006-08-31 |
| EP1850888A1 (en) | 2007-11-07 |
| EP1850888B1 (en) | 2008-09-17 |
| AU2006216085B2 (en) | 2011-10-20 |
| US20080300221A1 (en) | 2008-12-04 |
| PL1850888T3 (pl) | 2009-02-27 |
| AU2006216085A1 (en) | 2006-08-31 |
| CN101119755A (zh) | 2008-02-06 |
| WO2006089320A1 (en) | 2006-08-31 |
| AT501545A1 (de) | 2006-09-15 |
| ES2313607T3 (es) | 2009-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |