EA011866B1 - Агенты, специфически связывающие ангиопоэтин-2 - Google Patents

Агенты, специфически связывающие ангиопоэтин-2 Download PDF

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Publication number
EA011866B1
EA011866B1 EA200700876A EA200700876A EA011866B1 EA 011866 B1 EA011866 B1 EA 011866B1 EA 200700876 A EA200700876 A EA 200700876A EA 200700876 A EA200700876 A EA 200700876A EA 011866 B1 EA011866 B1 EA 011866B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
absent
antibodies
amino acid
specific binding
Prior art date
Application number
EA200700876A
Other languages
English (en)
Russian (ru)
Other versions
EA200700876A1 (ru
Inventor
Джонатон Даниел Олайнер
Кевин Грэхэм
Original Assignee
Амджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/982,440 external-priority patent/US7658924B2/en
Application filed by Амджен Инк. filed Critical Амджен Инк.
Publication of EA200700876A1 publication Critical patent/EA200700876A1/ru
Publication of EA011866B1 publication Critical patent/EA011866B1/ru

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA200700876A 2004-10-19 2005-10-19 Агенты, специфически связывающие ангиопоэтин-2 EA011866B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62016104P 2004-10-19 2004-10-19
US10/982,440 US7658924B2 (en) 2001-10-11 2004-11-04 Angiopoietin-2 specific binding agents
PCT/US2005/037911 WO2006045049A1 (en) 2004-10-19 2005-10-19 Angiopoietin-2 specific binding agents

Publications (2)

Publication Number Publication Date
EA200700876A1 EA200700876A1 (ru) 2007-10-26
EA011866B1 true EA011866B1 (ru) 2009-06-30

Family

ID=39608222

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700876A EA011866B1 (ru) 2004-10-19 2005-10-19 Агенты, специфически связывающие ангиопоэтин-2

Country Status (10)

Country Link
JP (2) JP2008520188A (enExample)
CN (1) CN101495513B (enExample)
BR (1) BRPI0518209A (enExample)
EA (1) EA011866B1 (enExample)
IL (1) IL182279A0 (enExample)
MA (1) MA29015B1 (enExample)
MX (1) MX2007004247A (enExample)
RU (2) RU2404992C2 (enExample)
SG (1) SG156668A1 (enExample)
ZA (1) ZA200704020B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101495513B (zh) * 2004-10-19 2014-08-06 安姆根有限公司 促血管生成素-2特异性结合剂
JO3182B1 (ar) * 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
EA022546B1 (ru) * 2011-09-28 2016-01-29 Федеральное Государственное Бюджетное Учреждение Науки Институт Биоорганической Химии Им. Академиков М.М. Шемякина И Ю.А. Овчинникова Российской Академии Наук Способ торможения роста карциномы эрлиха у лабораторного животного
SI2760471T1 (sl) * 2011-09-30 2017-04-26 Dana-Farber Cancer Institute, Inc. Terapevtski peptidi
JO3533B1 (ar) * 2012-01-23 2020-07-05 Regeneron Pharma تركيبات ثابته تحتوي على مضادات حيوية مقاومة لـ ang2
US9534007B2 (en) 2012-12-21 2017-01-03 The Regents Of The University Of California Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity
CA2912219C (en) 2013-05-14 2021-11-16 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
AR100270A1 (es) * 2014-05-19 2016-09-21 Lilly Co Eli Anticuerpos ang2
KR102329681B1 (ko) 2014-08-28 2021-11-23 에자이 알앤드디 매니지먼트 가부시키가이샤 고순도의 퀴놀린 유도체 및 이를 제조하는 방법
DK3263106T3 (da) 2015-02-25 2024-01-08 Eisai R&D Man Co Ltd Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat
WO2016140717A1 (en) 2015-03-04 2016-09-09 Merck Sharp & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
WO2016204193A1 (ja) 2015-06-16 2016-12-22 株式会社PRISM Pharma 抗がん剤
EP3338779B1 (en) 2015-08-20 2021-06-30 Eisai R&D Management Co., Ltd. Lenvatinib in combination with etoposide and ifosfamide for use in treating a tumor
CN106075448A (zh) * 2016-07-25 2016-11-09 广州道瑞医药科技有限公司 Angpt2抑制剂在制备用于治疗血管瘤的药物中的应用
CN106512006A (zh) * 2016-07-25 2017-03-22 广州道瑞医药科技有限公司 Angpt2分泌抑制剂在制备用于治疗血管瘤的药物中的应用
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
CA3061888A1 (en) 2017-05-16 2018-11-22 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
CN109096368B (zh) * 2018-09-30 2021-07-20 华南理工大学 一种同时具有抗氧化和护肝活性的多肽及编码该多肽的基因与其制备方法和应用
EP3932946A4 (en) * 2019-02-25 2023-03-22 Pharmabcine Inc. ANTI-ANG2 ANTIBODIES AND ITS USE
CN112126671B (zh) * 2020-08-18 2021-08-31 中山大学附属第五医院 无乳链球菌Streptococus agalactiae治疗子宫内膜异位症的应用
CN116265487B (zh) * 2021-12-16 2025-01-10 三优生物医药(上海)有限公司 抗ang2-vegf双特异性抗体及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057901A1 (en) * 1999-03-26 2000-10-05 Regeneron Pharmaceuticals, Inc. Modulation of vascular permeability by means of tie2 receptor activators
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20030236193A1 (en) * 2001-10-11 2003-12-25 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1308347C (zh) * 1999-04-28 2007-04-04 德克萨斯大学董事会 用于通过选择性抑制vegf来治疗癌症的组合物和方法
HUP0302779A3 (en) * 2000-06-23 2005-12-28 Schering Ag Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii)
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
CN101495513B (zh) * 2004-10-19 2014-08-06 安姆根有限公司 促血管生成素-2特异性结合剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057901A1 (en) * 1999-03-26 2000-10-05 Regeneron Pharmaceuticals, Inc. Modulation of vascular permeability by means of tie2 receptor activators
US20030236193A1 (en) * 2001-10-11 2003-12-25 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAI M. ET AL.: "Single chain Fv antibody against angiopoietin-2 inhibits VEGF-induced endothelial cell proliferation and migration in vitro". BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 309, no. 4, 3 October, 2003 (2003-10-03), pages 946-951, XP004455833, ISSN: 0006-291X *
OLINER J. ET AL.: "Suppression of angiogenesis and tumor growth by selective Inhibition of angiopoietin-2". CANCER CELL, XX, US, vol. 6, no. 5, November 2004 (2004-11), pages 507-516, XP002348738, ISSN: 1535-6108, the whole document *

Also Published As

Publication number Publication date
MX2007004247A (es) 2007-06-12
CN101495513A (zh) 2009-07-29
SG156668A1 (en) 2009-11-26
RU2010132956A (ru) 2012-02-10
ZA200704020B (en) 2008-06-25
JP2011207882A (ja) 2011-10-20
CN101495513B (zh) 2014-08-06
EA200700876A1 (ru) 2007-10-26
MA29015B1 (fr) 2007-11-01
RU2404992C2 (ru) 2010-11-27
RU2007118670A (ru) 2008-12-27
IL182279A0 (en) 2007-07-24
JP2008520188A (ja) 2008-06-19
BRPI0518209A (pt) 2008-11-04

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU