EA006439B1 - Пероральная пищевая добавка для лечения хронических изнуряющих заболеваний - Google Patents
Пероральная пищевая добавка для лечения хронических изнуряющих заболеваний Download PDFInfo
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- EA006439B1 EA006439B1 EA200400291A EA200400291A EA006439B1 EA 006439 B1 EA006439 B1 EA 006439B1 EA 200400291 A EA200400291 A EA 200400291A EA 200400291 A EA200400291 A EA 200400291A EA 006439 B1 EA006439 B1 EA 006439B1
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| PCT/US2002/025358 WO2003013438A2 (en) | 2001-08-10 | 2002-08-09 | Nutrient therapy for immuno-compromised patients |
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| EA200400291A1 EA200400291A1 (ru) | 2004-08-26 |
| EA006439B1 true EA006439B1 (ru) | 2005-12-29 |
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| EA200400291A EA006439B1 (ru) | 2001-08-10 | 2002-08-09 | Пероральная пищевая добавка для лечения хронических изнуряющих заболеваний |
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| US (1) | US6503506B1 (https=) |
| EP (1) | EP1432436A4 (https=) |
| JP (1) | JP2005501061A (https=) |
| CN (1) | CN1568196A (https=) |
| AP (1) | AP2004002994A0 (https=) |
| CA (1) | CA2457624A1 (https=) |
| EA (1) | EA006439B1 (https=) |
| OA (1) | OA12649A (https=) |
| WO (1) | WO2003013438A2 (https=) |
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| RU2656544C1 (ru) * | 2017-07-07 | 2018-06-05 | Общество с ограниченной ответственностью "Академия-Т" | Функциональный продукт питания для коррекции психофизиологического состояния и нейромышечной передачи у спортсменов |
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| FR2822704B1 (fr) * | 2001-03-29 | 2005-02-18 | Chiesi Sa | Sels de cetoacides et d'acides amines gastroresistants et leur utilisation pour la preparation de medicaments |
| US6503506B1 (en) * | 2001-08-10 | 2003-01-07 | Millenium Biotechnologies, Inc. | Nutrient therapy for immuno-compromised patients |
| US20080089877A1 (en) * | 2003-08-14 | 2008-04-17 | Udell Ronald G | Super Absorption Coenzyme Q10 |
| US8105583B2 (en) * | 2003-09-29 | 2012-01-31 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| US7169385B2 (en) * | 2003-09-29 | 2007-01-30 | Ronald G. Udell | Solubilized CoQ-10 and carnitine |
| US8124072B2 (en) | 2003-09-29 | 2012-02-28 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
| ITTO20030789A1 (it) | 2003-10-07 | 2005-04-08 | Professional Dietetics Srl | Composizione a base di amino acidi per il trattamento |
| JP5473190B2 (ja) * | 2003-10-16 | 2014-04-16 | ネステク ソシエテ アノニム | 化学療法又は放射線療法の副作用に対する栄養組成物 |
| KR101395370B1 (ko) | 2004-01-22 | 2014-05-14 | 유니버시티 오브 마이애미 | 국소용 코-엔자임 큐10 제형 및 그의 사용 방법 |
| PT1711070E (pt) * | 2004-01-28 | 2016-02-15 | Nestec Sa | Composição nutricional para melhorar o estado da pele e prevenir doenças de pele |
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| BRPI0508914A (pt) * | 2004-03-17 | 2007-08-14 | Arnold C Takemoto | desintoxicação de tecidos e suplementos para a saúde e processos de obtenção e de utilização dos mesmos |
| JP2005336176A (ja) * | 2004-04-28 | 2005-12-08 | Tanabe Seiyaku Co Ltd | 肉体疲労改善剤 |
| DE602004027120D1 (de) * | 2004-05-25 | 2010-06-24 | Cognis Ip Man Gmbh | Orale und/oder topische Zubereitungen |
| US20050265990A1 (en) * | 2004-06-01 | 2005-12-01 | Shawn Talbott | Treatments and nutritional supplements for assisting post-exercise recovery |
| EP2177907B1 (en) * | 2004-06-30 | 2014-01-01 | Atsuo Sekiyama | Indicator agent for noninflammatory stress response and use therefor |
| KR100584891B1 (ko) | 2004-08-13 | 2006-05-30 | (주)씨스팜 | 경구용 슈퍼옥사이드 디스뮤타제 제제인, 캔털루프 멜론추출물과 글리아딘 결합물을 숙취해소에 사용하는 방법 |
| US7284385B2 (en) * | 2004-09-16 | 2007-10-23 | Hess Spencer W | Pre-dried air reactivation for diesel fuel heated dessicant reactivator |
| JP5040060B2 (ja) * | 2004-10-14 | 2012-10-03 | 大正製薬株式会社 | メチオニン配合内服液剤 |
| US20060147550A1 (en) * | 2004-12-30 | 2006-07-06 | Gorsek Wayne F | Immune system enhancement and stimulation formulation |
| US20070114476A1 (en) * | 2005-11-04 | 2007-05-24 | Williams Christopher P | Low radiocarbon nucleotide and amino acid dietary supplements |
| US8329646B2 (en) * | 2005-11-30 | 2012-12-11 | Nestec S.A. | Methods for the treatment of muscle loss |
| JPWO2007077995A1 (ja) * | 2006-01-05 | 2009-06-11 | 協和発酵バイオ株式会社 | 筋肉増量剤 |
| GB0603975D0 (en) * | 2006-03-01 | 2006-04-05 | Etren | Methods and agents for reducing oxidative stress |
| CA2645674A1 (en) * | 2006-03-15 | 2007-09-20 | Isocell Pharma S.A. | Pharmaceutical compositions comprising sods and prolamine based peptide fragments |
| FR2899065B1 (fr) * | 2006-03-29 | 2008-07-18 | Alain Dreyer Brevets Et Dev So | Sod micro encapsulee et adsorbee sur support mineral et vegetal destinee a l'alimentation animale |
| DE102006046960A1 (de) * | 2006-10-04 | 2008-04-10 | Euro Allianz Pharma Gmbh | Gesundheitsfördernde Nahrungsmittelzusammensetzung |
| US20080119386A1 (en) * | 2006-11-22 | 2008-05-22 | Carl Germano | Nutritional formula for athletes' recovery |
| US8343541B2 (en) * | 2007-03-15 | 2013-01-01 | Soft Gel Technologies, Inc. | Ubiquinol and alpha lipoic acid compositions |
| EP2158462A4 (en) | 2007-05-03 | 2010-05-05 | Radiocarb Genetics Inc | FOOD SUPPLEMENTS WITH LITTLE RADIO CARBON AND MANUFACTURING METHOD THEREFOR |
| WO2009042230A1 (en) * | 2007-09-27 | 2009-04-02 | Biopolymer Engineering, Inc. Dba Biothera, Inc | ß-GLUCAN TREATMENT OF UPPER RESPIRATORY TRACT INFECTION SYMPTOMS AND PSYCHOLOGICAL WELL-BEING |
| WO2009099444A1 (en) * | 2008-02-08 | 2009-08-13 | Millennium Biotechnologies, Inc. | Nutritional formula for athletes' recovery |
| MX2010011032A (es) | 2008-04-11 | 2011-03-01 | Cytotech Labs Llc Star | Metodos y uso de induccion de apoptosis en celulas cancerigenas. |
| US8865733B2 (en) * | 2008-11-06 | 2014-10-21 | Altman Enterprises, LLC | Medication and treatment for disease |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| EP2311449A1 (de) * | 2009-10-14 | 2011-04-20 | NÖM Aktiengesellschaft | Oral verabreichbare nahrungsergänzende Zusammensetzung enthaltend Carnitin |
| PH12022550598A1 (en) | 2010-12-23 | 2024-03-11 | Amazentis Sa | Compositions and methods for improving mitochondrial function and treating neurodenegenerative diseases and cognitive disorders |
| WO2012097061A1 (en) * | 2011-01-13 | 2012-07-19 | Abbott Laboratories | Nutritional compositions and methods for improving skeletal muscle protein metabolism |
| BR112013018397A2 (pt) | 2011-01-18 | 2016-10-11 | Equine Nutriceuticals Llc | suplemento equino nutricional |
| CA2832324C (en) | 2011-04-04 | 2022-03-15 | Berg Llc | Methods of treating central nervous system tumors |
| NZ713868A (en) | 2013-04-08 | 2021-12-24 | Berg Llc | Treatment of cancer using coenzyme q10 combination therapies |
| KR102370843B1 (ko) | 2013-09-04 | 2022-03-04 | 버그 엘엘씨 | 코엔자임 q10의 연속주입에 의한 암치료 방법 |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| CN105709212A (zh) * | 2016-01-29 | 2016-06-29 | 周瑞华 | 一种免疫平衡调节剂及其制备方法和应用 |
| CA3109188A1 (en) * | 2018-08-10 | 2020-02-13 | Maine Natural Health Company, Inc. | Comestible compositions for promoting atp synthesis |
| CN110664824B (zh) * | 2019-08-09 | 2021-01-01 | 北京佳博泰和健康科技有限公司 | 一种营养支持剂及其制备方法和用途 |
| CN111820330A (zh) * | 2020-07-17 | 2020-10-27 | 禹城保立康生物饲料有限公司 | 一种提高哺乳仔猪发育的母猪饲料 |
| GB202308224D0 (en) | 2023-06-01 | 2023-07-19 | Amazentis Sa | Formulation |
Family Cites Families (5)
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|---|---|---|---|---|
| US5456924A (en) * | 1988-12-23 | 1995-10-10 | Immunotec Research Corporation Ltd. | Method of treatment of HIV-seropositive individuals with dietary whey proteins |
| IT1258491B (it) * | 1992-09-24 | 1996-02-26 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e acil l-carnitine nel trattamento di pazienti affetti da aids e sindromi correlate e di pazienti asintomatici hiv- sieropositivi. |
| FR2729296B1 (fr) | 1995-01-12 | 1997-03-28 | Europlanaire | Compositions pharmaceutiques comprenant une superoxyde dismutase |
| US5817329A (en) * | 1997-02-28 | 1998-10-06 | Gardiner; Paul T. | Nutritional supplement for increased muscle size and strength for body builders |
| US6503506B1 (en) * | 2001-08-10 | 2003-01-07 | Millenium Biotechnologies, Inc. | Nutrient therapy for immuno-compromised patients |
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- 2002-08-09 CN CNA028199790A patent/CN1568196A/zh active Pending
- 2002-08-09 EP EP02759316A patent/EP1432436A4/en not_active Ceased
- 2002-08-09 AP APAP/P/2004/002994A patent/AP2004002994A0/en unknown
- 2002-08-09 EA EA200400291A patent/EA006439B1/ru not_active IP Right Cessation
- 2002-08-09 JP JP2003518452A patent/JP2005501061A/ja active Pending
- 2002-08-09 WO PCT/US2002/025358 patent/WO2003013438A2/en not_active Ceased
- 2002-08-09 OA OA1200400043A patent/OA12649A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2656544C1 (ru) * | 2017-07-07 | 2018-06-05 | Общество с ограниченной ответственностью "Академия-Т" | Функциональный продукт питания для коррекции психофизиологического состояния и нейромышечной передачи у спортсменов |
Also Published As
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|---|---|
| CN1568196A (zh) | 2005-01-19 |
| OA12649A (en) | 2006-06-16 |
| AP2004002994A0 (en) | 2004-03-31 |
| EP1432436A4 (en) | 2005-02-09 |
| EP1432436A2 (en) | 2004-06-30 |
| EA200400291A1 (ru) | 2004-08-26 |
| US6503506B1 (en) | 2003-01-07 |
| JP2005501061A (ja) | 2005-01-13 |
| WO2003013438A2 (en) | 2003-02-20 |
| CA2457624A1 (en) | 2003-02-20 |
| WO2003013438A3 (en) | 2003-06-19 |
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