EA001316B1 - Соединения, обладающие антивирусной активностью - Google Patents

Соединения, обладающие антивирусной активностью Download PDF

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Publication number
EA001316B1
EA001316B1 EA199801078A EA199801078A EA001316B1 EA 001316 B1 EA001316 B1 EA 001316B1 EA 199801078 A EA199801078 A EA 199801078A EA 199801078 A EA199801078 A EA 199801078A EA 001316 B1 EA001316 B1 EA 001316B1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
pharmaceutically acceptable
hydrogen
compound
acceptable salt
Prior art date
Application number
EA199801078A
Other languages
English (en)
Russian (ru)
Other versions
EA199801078A1 (ru
Inventor
Луи Н. Юнгхейм
Тимоти А. Шеферд
Вейн А. Спитцер
Марк Дж. Теббе
Original Assignee
Эли Лилли Энд Компании
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компании filed Critical Эли Лилли Энд Компании
Publication of EA199801078A1 publication Critical patent/EA199801078A1/ru
Publication of EA001316B1 publication Critical patent/EA001316B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA199801078A 1996-06-05 1997-06-05 Соединения, обладающие антивирусной активностью EA001316B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1917096P 1996-06-05 1996-06-05
PCT/US1997/008848 WO1997046237A1 (en) 1996-06-05 1997-06-05 Anti-viral compounds

Publications (2)

Publication Number Publication Date
EA199801078A1 EA199801078A1 (ru) 1999-04-29
EA001316B1 true EA001316B1 (ru) 2001-02-26

Family

ID=21791797

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199801078A EA001316B1 (ru) 1996-06-05 1997-06-05 Соединения, обладающие антивирусной активностью

Country Status (9)

Country Link
EP (1) EP0906097A4 (de)
JP (1) JP2000511899A (de)
KR (1) KR20000016346A (de)
CN (1) CN1220601A (de)
AU (1) AU3212897A (de)
BR (1) BR9709528A (de)
CA (1) CA2257296A1 (de)
EA (1) EA001316B1 (de)
WO (1) WO1997046237A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
AU6031898A (en) * 1997-01-22 1998-08-07 Eli Lilly And Company Anti-viral compounds
WO1998055120A1 (en) * 1997-06-04 1998-12-10 Eli Lilly And Company Anti-viral compounds
CA2332403A1 (en) * 1998-05-20 1999-11-25 Jesus Ezquerra-Carrera Anti-viral compounds
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
CA2363274A1 (en) 1999-12-27 2001-07-05 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs for hepatitis c
EP1651631A1 (de) 2003-08-01 2006-05-03 Genelabs Technologies, Inc. Bicyclische imidazolderivate gegen flaviviridae
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
DE602005013922D1 (de) 2004-02-24 2009-05-28 Japan Tobacco Inc Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles

Also Published As

Publication number Publication date
EP0906097A1 (de) 1999-04-07
JP2000511899A (ja) 2000-09-12
EA199801078A1 (ru) 1999-04-29
EP0906097A4 (de) 2000-12-13
CA2257296A1 (en) 1997-12-11
KR20000016346A (ko) 2000-03-25
CN1220601A (zh) 1999-06-23
WO1997046237A1 (en) 1997-12-11
AU3212897A (en) 1998-01-05
BR9709528A (pt) 1999-08-10

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU