DOP2025000054A - Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínica - Google Patents
Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínicaInfo
- Publication number
- DOP2025000054A DOP2025000054A DO2025000054A DO2025000054A DOP2025000054A DO P2025000054 A DOP2025000054 A DO P2025000054A DO 2025000054 A DO2025000054 A DO 2025000054A DO 2025000054 A DO2025000054 A DO 2025000054A DO P2025000054 A DOP2025000054 A DO P2025000054A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- pyrazolo
- carbonitrile
- triazol
- pyridin
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263404232P | 2022-09-07 | 2022-09-07 | |
| PCT/US2023/073508 WO2024054814A1 (en) | 2022-09-07 | 2023-09-06 | Co-crystals of 4-[4-[3-chloro-4-[1-(2-pyridyl)-2-hydroxy-ethoxy]pyrazolo[1,5-a]pyridin-6-yl]-5-methyl- triazol-1-yl]piperidine-1 -carbonitrile derivatives with gallic acid and nicotine amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2025000054A true DOP2025000054A (es) | 2025-03-31 |
Family
ID=88204177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2025000054A DOP2025000054A (es) | 2022-09-07 | 2025-03-06 | Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínica |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20240116932A1 (https=) |
| EP (1) | EP4584270A1 (https=) |
| JP (2) | JP7541606B2 (https=) |
| KR (1) | KR20250057022A (https=) |
| CN (1) | CN120187720A (https=) |
| AR (1) | AR130417A1 (https=) |
| AU (1) | AU2023338199A1 (https=) |
| CA (1) | CA3266872A1 (https=) |
| CL (1) | CL2025000596A1 (https=) |
| CO (1) | CO2025002467A2 (https=) |
| CR (1) | CR20250077A (https=) |
| DO (1) | DOP2025000054A (https=) |
| IL (1) | IL319342A (https=) |
| JO (1) | JOP20250053A1 (https=) |
| MX (1) | MX2025002687A (https=) |
| PE (1) | PE20251400A1 (https=) |
| TW (1) | TWI862146B (https=) |
| WO (1) | WO2024054814A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025259519A1 (en) | 2024-06-13 | 2025-12-18 | Eli Lilly And Company | Activation of egfr/her2/3 in cancer after treatment with an inhibitor of fibroblast growth factor receptor 3 (fgfr3) |
| WO2026037249A1 (zh) * | 2024-08-13 | 2026-02-19 | 海思科医药集团股份有限公司 | 取代杂环类衍生物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1962600B1 (en) * | 2005-12-08 | 2013-05-01 | New Form Pharmaceuticals Inc. | Metronidazole cocrystals |
| PH12012000132A1 (en) * | 2011-06-09 | 2014-10-20 | Servier Lab | New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them |
| CN102964384B (zh) * | 2012-11-09 | 2015-06-24 | 中山大学 | 阿德福韦酯没食子酸共晶及其制备方法和组合物 |
| EP3752159A4 (en) * | 2018-02-13 | 2021-11-24 | Transgenex Nanobiotech, Inc. | NEW CRYSTALLINE FORMS OF TAMIBAROTENE FOR CANCER TREATMENT |
| WO2020131627A1 (en) * | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| CN111574359A (zh) * | 2019-02-19 | 2020-08-25 | 愈磐生物科技（苏州）有限公司 | 乐伐替尼-没食子酸共晶晶型及其应用 |
| CN113943284B (zh) * | 2020-07-15 | 2023-12-19 | 中国医学科学院药物研究所 | 盐酸吡格列酮没食子酸共晶及制备方法和其组合物与用途 |
| AR125588A1 (es) * | 2021-03-04 | 2023-08-02 | Lilly Co Eli | Compuestos inhibidores de fgfr3 |
-
2023
- 2023-09-06 EP EP23777475.7A patent/EP4584270A1/en active Pending
- 2023-09-06 CA CA3266872A patent/CA3266872A1/en active Pending
- 2023-09-06 KR KR1020257010708A patent/KR20250057022A/ko not_active Ceased
- 2023-09-06 IL IL319342A patent/IL319342A/en unknown
- 2023-09-06 CN CN202380077374.0A patent/CN120187720A/zh active Pending
- 2023-09-06 PE PE2025000482A patent/PE20251400A1/es unknown
- 2023-09-06 WO PCT/US2023/073508 patent/WO2024054814A1/en not_active Ceased
- 2023-09-06 AU AU2023338199A patent/AU2023338199A1/en active Pending
- 2023-09-06 CR CR20250077A patent/CR20250077A/es unknown
- 2023-09-06 US US18/462,286 patent/US20240116932A1/en active Pending
- 2023-09-07 TW TW112133993A patent/TWI862146B/zh active
- 2023-09-07 AR ARP230102376A patent/AR130417A1/es unknown
- 2023-09-07 JP JP2023145013A patent/JP7541606B2/ja active Active
-
2024
- 2024-08-16 JP JP2024136962A patent/JP2024153948A/ja active Pending
-
2025
- 2025-02-28 CO CONC2025/0002467A patent/CO2025002467A2/es unknown
- 2025-03-04 CL CL2025000596A patent/CL2025000596A1/es unknown
- 2025-03-06 DO DO2025000054A patent/DOP2025000054A/es unknown
- 2025-03-06 JO JOJO/P/2025/0053A patent/JOP20250053A1/ar unknown
- 2025-03-06 MX MX2025002687A patent/MX2025002687A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024054814A1 (en) | 2024-03-14 |
| JP2024037713A (ja) | 2024-03-19 |
| CO2025002467A2 (es) | 2025-03-17 |
| CN120187720A (zh) | 2025-06-20 |
| CR20250077A (es) | 2025-04-02 |
| CA3266872A1 (en) | 2024-03-14 |
| JOP20250053A1 (ar) | 2025-03-06 |
| EP4584270A1 (en) | 2025-07-16 |
| JP7541606B2 (ja) | 2024-08-28 |
| US20240116932A1 (en) | 2024-04-11 |
| AU2023338199A1 (en) | 2025-03-20 |
| CL2025000596A1 (es) | 2025-04-25 |
| PE20251400A1 (es) | 2025-05-22 |
| JP2024153948A (ja) | 2024-10-29 |
| KR20250057022A (ko) | 2025-04-28 |
| IL319342A (en) | 2025-05-01 |
| AR130417A1 (es) | 2024-12-04 |
| TWI862146B (zh) | 2024-11-11 |
| MX2025002687A (es) | 2025-04-02 |
| TW202428260A (zh) | 2024-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2025000054A (es) | Derivados de co-cristales de 4-[4-[3-cloro-4-[1-(2-piridil)-2-hidroxi-etoxi]pirazolo[1,5-a]piridin-6-il]-5-metil-triazol-1-il]piperidina-1-carbonitrilo con ácido gálico y amida nicotínica | |
| St-Jacques et al. | Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors | |
| CN1947717B (zh) | 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用 | |
| KR20230049620A (ko) | 교류 전기장에 대한 암세포 민감도를 증가시키기 위한 방법 및 조성물 | |
| UY27811A1 (es) | 3-aminopirazoles n-sustituidos como inhibidores para el tratamiento de los desórdenes proliferativos de las células. | |
| MXPA06008157A (es) | Tratamiento de gliomas malignos con inhibidores de factor de crecimiento transformante-beta. | |
| HUP0102240A2 (hu) | Indigoid biszindolszármazékok alkalmazása ciklinfüggő kinázok gátlására szolgáló gyógyszer előállítására | |
| CL2011000880A1 (es) | Compuestos derivados de pirazolo[1,5-a]pirimidin-3-il, inhibidores de tirosina de la familia trk cinasa; proceso para la preparacion de los compuestos; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos utiles para el tratamiento del dolor y del cancer. | |
| EA202091450A1 (ru) | Производные 2h-индазола в качестве ингибиторов cdk4 и cdk6 и их терапевтические применения | |
| Hu et al. | Indirubin-3-oxime effectively prevents 6OHDA-induced neurotoxicity in PC12 cells via activating MEF2D through the inhibition of GSK3β | |
| Kranz et al. | Phosphodiesterase type 4 inhibitor rolipram improves survival of spiral ganglion neurons in vitro | |
| MX2023005626A (es) | Derivados de pirazolo[1.5-a]pirazina como inhibidores de la btk. | |
| BR112023011451A2 (pt) | Inibidores de alk-5 e seus usos | |
| EA202190323A1 (ru) | ИМИДАЗО[1,2-b]ПИРИДАЗИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ Trk | |
| AR132251A1 (es) | Derivados de 5-amino-6,8-dihidro-1h-furo[3,4-d]pirrolo[3,2-b]piridin-2-carboxamida como inhibidores cooperativos con mta de prmt5 | |
| Bengoetxea et al. | Environmental enrichment reverses tyrosine kinase inhibitor-mediated impairment through BDNF-TrkB pathway | |
| CN119454695A (zh) | Csf1r激酶抑制剂及其用途 | |
| Bortolotto et al. | Proneurogenic effects of trazodone in murine and human neural progenitor cells | |
| CN114401723B (zh) | 用于治疗癌症的治疗性组合物和方法 | |
| Rech et al. | Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl) benzofuran in male Swiss mice | |
| CO2025001456A2 (es) | Inhibidores de tirosina cinasa 2 y usos de estos | |
| US10487054B2 (en) | Therapeutic compounds | |
| KR20190063792A (ko) | 슈반세포 분화용 배지 조성물 및 상기 배지 조성물을 이용한 체세포로부터 슈반세포로의 분화 방법 | |
| AR131414A1 (es) | Inhibidores de la proteína tirosina fosfatasa, composiciones y métodos de uso | |
| AR131001A1 (es) | Inhibidores de la proteína tirosina fosfatasa, composiciones y métodos de uso |