DOP2015000147A - Derivados de imidazopiridazina como moduladores del receptor gabaa - Google Patents

Derivados de imidazopiridazina como moduladores del receptor gabaa

Info

Publication number
DOP2015000147A
DOP2015000147A DO2015000147A DO2015000147A DOP2015000147A DO P2015000147 A DOP2015000147 A DO P2015000147A DO 2015000147 A DO2015000147 A DO 2015000147A DO 2015000147 A DO2015000147 A DO 2015000147A DO P2015000147 A DOP2015000147 A DO P2015000147A
Authority
DO
Dominican Republic
Prior art keywords
derivatives
gabaa
imidazopiridazine
receiver modulators
present
Prior art date
Application number
DO2015000147A
Other languages
English (en)
Inventor
Kiyoyuki Omoto
Robert Mckenzie Owen
David Cameron Pryde
Christine Anne Louise Watson
Mifune Takeuchi
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of DOP2015000147A publication Critical patent/DOP2015000147A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

La presente invención se refiere a derivados de imidazopiridazina. Más en particular, se refiere a derivados de 4-(bifenil-3-il)-7H-imidazo[4,5-c]piridazina de la Fórmula (I): y a sales de estos aceptables desde el punto de vista farmacéutico, en donde R1, R2, R3, R4 y R5 son como se definieron en la descripción. Los derivados de imidazopiridazina de la presente invención modulan la actividad del receptor GABAA. Son útiles para la fabriacación de medicamentos útiles en el tratamiento de diversas afecciones, por ejemplo, el dolor.
DO2015000147A 2012-12-14 2015-06-12 Derivados de imidazopiridazina como moduladores del receptor gabaa DOP2015000147A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261737157P 2012-12-14 2012-12-14

Publications (1)

Publication Number Publication Date
DOP2015000147A true DOP2015000147A (es) 2015-09-15

Family

ID=49880883

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2015000147A DOP2015000147A (es) 2012-12-14 2015-06-12 Derivados de imidazopiridazina como moduladores del receptor gabaa

Country Status (44)

Country Link
US (3) US8952008B2 (es)
EP (1) EP2938615B1 (es)
JP (1) JP5869740B2 (es)
KR (1) KR101746314B1 (es)
CN (1) CN104837843B (es)
AP (1) AP2015008526A0 (es)
AR (1) AR093937A1 (es)
AU (1) AU2013356894B2 (es)
BR (1) BR112015014097B1 (es)
CA (1) CA2892174C (es)
CL (1) CL2015001652A1 (es)
CR (1) CR20150254A (es)
CU (1) CU24338B1 (es)
CY (1) CY1118568T1 (es)
DK (1) DK2938615T3 (es)
DO (1) DOP2015000147A (es)
EA (1) EA025635B1 (es)
EC (1) ECSP15029822A (es)
ES (1) ES2608640T3 (es)
GE (1) GEP201706710B (es)
GT (1) GT201500159A (es)
HK (1) HK1209743A1 (es)
HR (1) HRP20161559T1 (es)
HU (1) HUE032400T2 (es)
IL (1) IL239243A0 (es)
LT (1) LT2938615T (es)
MA (1) MA38112B1 (es)
MD (1) MD4651B1 (es)
ME (1) ME02566B (es)
MX (1) MX366023B (es)
NI (1) NI201500081A (es)
PE (1) PE20151163A1 (es)
PH (1) PH12015501293B1 (es)
PL (1) PL2938615T3 (es)
PT (1) PT2938615T (es)
RS (1) RS55307B1 (es)
SG (1) SG11201503735YA (es)
SI (1) SI2938615T1 (es)
TN (1) TN2015000261A1 (es)
TW (1) TWI478926B (es)
UA (1) UA112028C2 (es)
UY (1) UY35185A (es)
WO (1) WO2014091368A1 (es)
ZA (1) ZA201504226B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9802945B2 (en) * 2014-06-12 2017-10-31 Pfizer Limited Imidazopyridazine derivatives as modulators of the GABAA receptor activity
RU2712192C2 (ru) 2014-07-31 2020-01-24 Басф Се Способ получения пиразолов
PE20180327A1 (es) 2015-05-11 2018-02-13 Basf Se Proceso para preparar 4-amino-piridazinas
CA3007595C (en) * 2015-12-10 2020-08-25 Pfizer Limited 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain
TWI651308B (zh) * 2016-09-23 2019-02-21 瑞士商諾華公司 用於肌腱及/或韌帶傷害之吲唑化合物
JOP20190053A1 (ar) * 2016-09-23 2019-03-21 Novartis Ag مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
US11089783B2 (en) 2017-05-02 2021-08-17 Bayer Aktiengesellschaft 2-(het)aryl-substituted fused heterocycle derivatives as pesticides
CA3064989A1 (en) 2017-06-06 2018-12-13 Urovant Sciences Gmbh Use of vibegron to treat overactive bladder
WO2019226820A1 (en) * 2018-05-22 2019-11-28 Neurocycle Therapeutics, Inc. Gabaa positive allosteric modulator compounds for treatment of itch and/ or dermatitis
TW202214648A (zh) * 2019-01-07 2022-04-16 美商美國禮來大藥廠 Il-17a抑制劑
CN116693555A (zh) 2022-02-25 2023-09-05 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
CN117069725A (zh) * 2022-05-10 2023-11-17 上海赛默罗生物科技有限公司 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
GB0117277D0 (en) * 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
ES2251518T3 (es) 2000-11-10 2006-05-01 MERCK SHARP & DOHME LTD. Derivados de imidazo-triazina como ligandos para receptores gaba.
EP1713784A1 (en) * 2004-02-12 2006-10-25 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
EP1838152A2 (en) 2005-01-21 2007-10-03 Neurogen Corporation Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
DE602008000809D1 (de) 2007-03-23 2010-04-29 Icagen Inc Ionenkanal-Hemmer
PE20142099A1 (es) 2009-01-12 2014-12-13 Icagen Inc Derivados de sulfonamida
EP2493889B1 (en) * 2009-10-30 2017-09-06 Janssen Pharmaceutica, N.V. IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
US9096558B2 (en) * 2010-07-09 2015-08-04 Pfizer Limited N-sulfonylbenzamide compounds

Also Published As

Publication number Publication date
US20150259352A1 (en) 2015-09-17
TN2015000261A1 (fr) 2016-10-03
CR20150254A (es) 2015-07-09
HUE032400T2 (hu) 2017-09-28
MX2015007598A (es) 2015-10-22
WO2014091368A1 (en) 2014-06-19
US8952008B2 (en) 2015-02-10
SI2938615T1 (sl) 2017-02-28
MD4651B1 (ro) 2019-09-30
EA025635B1 (ru) 2017-01-30
KR101746314B1 (ko) 2017-06-12
EP2938615B1 (en) 2016-10-26
PT2938615T (pt) 2016-12-26
JP2016503001A (ja) 2016-02-01
UA112028C2 (uk) 2016-07-11
PH12015501293A1 (en) 2015-08-24
PE20151163A1 (es) 2015-08-14
EP2938615A1 (en) 2015-11-04
AP2015008526A0 (en) 2015-06-30
HK1209743A1 (zh) 2016-04-08
CN104837843A (zh) 2015-08-12
MX366023B (es) 2019-06-24
GEP201706710B (en) 2017-07-25
BR112015014097B1 (pt) 2022-11-29
ZA201504226B (en) 2016-06-29
ME02566B (me) 2017-02-20
ES2608640T3 (es) 2017-04-12
CA2892174A1 (en) 2014-06-19
KR20150088877A (ko) 2015-08-03
CY1118568T1 (el) 2017-07-12
NI201500081A (es) 2015-09-16
IL239243A0 (en) 2015-07-30
UY35185A (es) 2014-07-31
LT2938615T (lt) 2016-12-27
TW201434840A (zh) 2014-09-16
MD20150051A2 (ro) 2015-09-30
RS55307B1 (sr) 2017-03-31
US20150105396A1 (en) 2015-04-16
PL2938615T3 (pl) 2017-04-28
HRP20161559T1 (hr) 2016-12-30
PH12015501293B1 (en) 2015-08-24
BR112015014097A2 (pt) 2019-12-17
GT201500159A (es) 2015-09-23
MA38112B1 (fr) 2018-10-31
SG11201503735YA (en) 2015-07-30
MA38112A1 (fr) 2018-03-30
TWI478926B (zh) 2015-04-01
CA2892174C (en) 2018-02-06
AR093937A1 (es) 2015-07-01
CU20150058A7 (es) 2015-11-27
DK2938615T3 (da) 2017-01-02
EA201590761A1 (ru) 2015-12-30
ECSP15029822A (es) 2017-08-31
US20140171435A1 (en) 2014-06-19
AU2013356894B2 (en) 2015-11-12
CN104837843B (zh) 2016-08-31
AU2013356894A1 (en) 2015-05-28
CL2015001652A1 (es) 2015-08-14
JP5869740B2 (ja) 2016-02-24
CU24338B1 (es) 2018-04-03

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