UY35185A - ?Derivados de 4-(bifenil-3-il)-7H-imidazo[4,5-c]piridazina?. - Google Patents
?Derivados de 4-(bifenil-3-il)-7H-imidazo[4,5-c]piridazina?.Info
- Publication number
- UY35185A UY35185A UY35185A UY35185A UY35185A UY 35185 A UY35185 A UY 35185A UY 35185 A UY35185 A UY 35185A UY 35185 A UY35185 A UY 35185A UY 35185 A UY35185 A UY 35185A
- Authority
- UY
- Uruguay
- Prior art keywords
- imidazo
- biphenyl
- pyridazine derivatives
- derivatives
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a derivados de imidazopiridazina. Más en particular, se refiere a derivados de 4-(bifenil-3-il)-7H-imidazo[4,5-c]piridazina de la Fórmula (I):y a sales de estos acept ables desde el punto de vista farmacéutico, en donde R1, R2,R3, R4 y R5 son como se definieron en la descripción. Los derivados de imidazopiridazina de la presente invención modulan la actividad del receptor GABAA.Son útiles para el tratamiento de diversas afecciones, por ejemplo, el dolor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261737157P | 2012-12-14 | 2012-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY35185A true UY35185A (es) | 2014-07-31 |
Family
ID=49880883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY35185A UY35185A (es) | 2012-12-14 | 2013-12-12 | ?Derivados de 4-(bifenil-3-il)-7H-imidazo[4,5-c]piridazina?. |
Country Status (44)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2951497C (en) * | 2014-06-12 | 2019-04-09 | Pfizer Limited | Imidazopyridazine derivatives as modulators of the gabaa receptor activity |
| CN106573893B (zh) | 2014-07-31 | 2020-06-09 | 巴斯夫欧洲公司 | 制备吡唑的方法 |
| PE20180327A1 (es) | 2015-05-11 | 2018-02-13 | Basf Se | Proceso para preparar 4-amino-piridazinas |
| CA3007595C (en) * | 2015-12-10 | 2020-08-25 | Pfizer Limited | 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain |
| JOP20190053A1 (ar) * | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
| EA038510B1 (ru) * | 2016-09-23 | 2021-09-08 | Новартис Аг | Индазольные соединения для применения при повреждениях сухожилий и/или связок |
| WO2018082964A1 (en) | 2016-11-04 | 2018-05-11 | Basf Se | Process for the production of pyridazinyl-amides in a one-pot synthesis |
| KR20200003047A (ko) | 2017-05-02 | 2020-01-08 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 2-(헤트)아릴-치환된 축합된 비시클릭 헤테로시클릭 유도체 |
| CA3064989A1 (en) * | 2017-06-06 | 2018-12-13 | Urovant Sciences Gmbh | Use of vibegron to treat overactive bladder |
| WO2019226820A1 (en) * | 2018-05-22 | 2019-11-28 | Neurocycle Therapeutics, Inc. | Gabaa positive allosteric modulator compounds for treatment of itch and/ or dermatitis |
| TW202214648A (zh) * | 2019-01-07 | 2022-04-16 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
| CN116693555A (zh) * | 2022-02-25 | 2023-09-05 | 上海赛默罗生物科技有限公司 | 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
| CN117069725A (zh) * | 2022-05-10 | 2023-11-17 | 上海赛默罗生物科技有限公司 | 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US6365589B1 (en) * | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| WO2002038568A1 (en) | 2000-11-10 | 2002-05-16 | Merck Sharp & Dohme Limited | Imidazo-triazine derivatives as ligands for gaba receptors |
| GB0117277D0 (en) * | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| WO2005080355A1 (en) * | 2004-02-12 | 2005-09-01 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands |
| WO2006078891A2 (en) | 2005-01-21 | 2006-07-27 | Neurogen Corporation | Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| WO2008118758A1 (en) | 2007-03-23 | 2008-10-02 | Icagen, Inc. | Inhibitors of ion channels |
| HUE025013T2 (hu) | 2009-01-12 | 2016-04-28 | Pfizer Ltd | Szulfonamid-származékok |
| WO2011051342A1 (en) * | 2009-10-30 | 2011-05-05 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| CA2803118C (en) * | 2010-07-09 | 2015-11-03 | Pfizer Limited | Sulfonamide derivatives as nav 1.7 inhibitors |
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2013
- 2013-04-12 UA UAA201504677A patent/UA112028C2/uk unknown
- 2013-12-04 MA MA38112A patent/MA38112B1/fr unknown
- 2013-12-04 ES ES13812165.2T patent/ES2608640T3/es active Active
- 2013-12-04 MX MX2015007598A patent/MX366023B/es active IP Right Grant
- 2013-12-04 SI SI201330382T patent/SI2938615T1/sl unknown
- 2013-12-04 DK DK13812165.2T patent/DK2938615T3/da active
- 2013-12-04 PL PL13812165T patent/PL2938615T3/pl unknown
- 2013-12-04 HU HUE13812165A patent/HUE032400T2/hu unknown
- 2013-12-04 PT PT138121652T patent/PT2938615T/pt unknown
- 2013-12-04 KR KR1020157017073A patent/KR101746314B1/ko active IP Right Grant
- 2013-12-04 WO PCT/IB2013/060631 patent/WO2014091368A1/en active Application Filing
- 2013-12-04 LT LTEP13812165.2T patent/LT2938615T/lt unknown
- 2013-12-04 JP JP2015547219A patent/JP5869740B2/ja active Active
- 2013-12-04 CU CUP2015000058A patent/CU24338B1/es unknown
- 2013-12-04 MD MDA20150051A patent/MD4651B1/ro not_active IP Right Cessation
- 2013-12-04 AU AU2013356894A patent/AU2013356894B2/en active Active
- 2013-12-04 AP AP2015008526A patent/AP2015008526A0/xx unknown
- 2013-12-04 GE GEAP201313849A patent/GEP201706710B/en unknown
- 2013-12-04 EP EP13812165.2A patent/EP2938615B1/en active Active
- 2013-12-04 ME MEP-2016-258A patent/ME02566B/me unknown
- 2013-12-04 EA EA201590761A patent/EA025635B1/ru not_active IP Right Cessation
- 2013-12-04 SG SG11201503735YA patent/SG11201503735YA/en unknown
- 2013-12-04 CA CA2892174A patent/CA2892174C/en active Active
- 2013-12-04 PE PE2015000912A patent/PE20151163A1/es not_active Application Discontinuation
- 2013-12-04 BR BR112015014097-1A patent/BR112015014097B1/pt active IP Right Grant
- 2013-12-04 RS RS20160986A patent/RS55307B1/sr unknown
- 2013-12-04 CN CN201380065006.0A patent/CN104837843B/zh active Active
- 2013-12-11 TW TW102145600A patent/TWI478926B/zh active
- 2013-12-12 US US14/103,960 patent/US8952008B2/en active Active
- 2013-12-12 UY UY35185A patent/UY35185A/es unknown
- 2013-12-12 AR ARP130104648A patent/AR093937A1/es unknown
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2014
- 2014-12-19 US US14/576,796 patent/US20150105396A1/en not_active Abandoned
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2015
- 2015-05-14 CR CR20150254A patent/CR20150254A/es unknown
- 2015-05-29 US US14/725,234 patent/US20150259352A1/en not_active Abandoned
- 2015-06-04 IL IL239243A patent/IL239243A0/en active IP Right Grant
- 2015-06-05 PH PH12015501293A patent/PH12015501293A1/en unknown
- 2015-06-09 TN TNP2015000261A patent/TN2015000261A1/fr unknown
- 2015-06-11 NI NI201500081A patent/NI201500081A/es unknown
- 2015-06-11 ZA ZA2015/04226A patent/ZA201504226B/en unknown
- 2015-06-12 CL CL2015001652A patent/CL2015001652A1/es unknown
- 2015-06-12 DO DO2015000147A patent/DOP2015000147A/es unknown
- 2015-07-11 EC ECIEPI201529822A patent/ECSP15029822A/es unknown
- 2015-08-04 GT GT201500159A patent/GT201500159A/es unknown
- 2015-10-28 HK HK15110627.3A patent/HK1209743A1/zh unknown
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2016
- 2016-11-22 HR HRP20161559TT patent/HRP20161559T1/hr unknown
- 2016-12-05 CY CY20161101251T patent/CY1118568T1/el unknown
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