DK641589A - N-aryl-azetidinoner, fremgangsmaade til deres fremstilling og deres anvendelse som elastaseinhibitorer - Google Patents

N-aryl-azetidinoner, fremgangsmaade til deres fremstilling og deres anvendelse som elastaseinhibitorer Download PDF

Info

Publication number
DK641589A
DK641589A DK641589A DK641589A DK641589A DK 641589 A DK641589 A DK 641589A DK 641589 A DK641589 A DK 641589A DK 641589 A DK641589 A DK 641589A DK 641589 A DK641589 A DK 641589A
Authority
DK
Denmark
Prior art keywords
azetidinones
aryl
procedures
preparation
elastase inhibitors
Prior art date
Application number
DK641589A
Other languages
Danish (da)
English (en)
Other versions
DK641589D0 (da
Inventor
Roger Joyeau
Randa Kobaiter
Michel Wakselman
Michele Reboud
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Publication of DK641589D0 publication Critical patent/DK641589D0/da
Publication of DK641589A publication Critical patent/DK641589A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK641589A 1988-12-19 1989-12-18 N-aryl-azetidinoner, fremgangsmaade til deres fremstilling og deres anvendelse som elastaseinhibitorer DK641589A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8816732A FR2640621B1 (fr) 1988-12-19 1988-12-19 N-aryl-azetidinones, leur procede de preparation et leur utilisation comme inhibiteurs des elastases

Publications (2)

Publication Number Publication Date
DK641589D0 DK641589D0 (da) 1989-12-18
DK641589A true DK641589A (da) 1990-06-20

Family

ID=9373095

Family Applications (1)

Application Number Title Priority Date Filing Date
DK641589A DK641589A (da) 1988-12-19 1989-12-18 N-aryl-azetidinoner, fremgangsmaade til deres fremstilling og deres anvendelse som elastaseinhibitorer

Country Status (11)

Country Link
US (1) US5030628A (xx)
EP (1) EP0375527A1 (xx)
JP (1) JPH0334966A (xx)
AU (1) AU628445B2 (xx)
CA (1) CA2005759A1 (xx)
DK (1) DK641589A (xx)
FR (1) FR2640621B1 (xx)
NZ (1) NZ231817A (xx)
OA (1) OA09432A (xx)
PT (1) PT92612A (xx)
ZA (1) ZA899725B (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2525125B2 (ja) * 1991-07-23 1996-08-14 シェリング・コーポレーション 血清コレステロ―ル低下薬として有用な置換β−ラクタム化合物およびそれらの製法
US5688785A (en) * 1991-07-23 1997-11-18 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5688787A (en) * 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
FR2755015B1 (fr) * 1996-10-25 1998-12-24 Sod Conseils Rech Applic Utilisation d'un extrait flavonoidique de ginkgo biloba substantiellement depourvu de terpenes, dans le domaine buccodentaire, et composition contenant un tel extrait
JP2001524132A (ja) * 1997-05-09 2001-11-27 スミスクライン・ビーチャム・コーポレイション ＣｏＡ−ＩＴのベータ−ラクタム阻害剤
US6274597B1 (en) * 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
WO2000063703A1 (en) * 1999-04-16 2000-10-26 Schering Corporation Use of azetidinone compounds
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
SK287746B6 (sk) * 2001-01-26 2011-08-04 Schering Corporation Použitie substituovaných azetidinónových zlúčenín na liečenie sitosterolémie
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
AR033855A1 (es) * 2001-01-26 2004-01-07 Schering Corp Composiciones y combinaciones de activador(es) del receptor de activacion de proliferacion peroxis0mal (ppar) e inhibidor(es) de absorcion de esterol, el uso de dichas composiciones o combinaciones para la manufactura de un medicamento para el tratamiento para indicaciones vasculares, diabetes, obes
AR034204A1 (es) * 2001-01-26 2004-02-04 Schering Corp Composiciones y combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y el uso de los mismos para preparar medicamentos para el tratamiento para indicaciones vasculares
KR20080067717A (ko) * 2001-01-26 2008-07-21 쉐링 코포레이션 스테롤 흡수 억제제와 혈액 조절제를 포함하는 혈관 질환의치료 또는 예방용 약제학적 조성물
AR035739A1 (es) * 2001-01-26 2004-07-07 Schering Corp Composiciones farmaceuticas y combinaciones terapeuticas que comprenden secuestrante (s) de los acidos biliares y de inhibidor (es) de la absorcion de los esteroles y el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento de indicaciones vasculares
AR032643A1 (es) * 2001-01-26 2003-11-19 Schering Corp Combinaciones de inhibidor(es) de absorcion de esterol con agente(s) cardiovascular(es) para el tratamiento de condiciones vasculares
CZ304929B6 (cs) 2001-03-28 2015-01-28 Merck Sharp & Dohme Corp. Enantioselektivní syntéza azetidinonových meziproduktů
PT1392287E (pt) * 2001-05-25 2007-02-28 Schering Corp Métodos para tratamento de doença de alzheimer e/ou regulação dos níveis de peptídeos β amilóide num sujeito
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119757A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
DK1429756T3 (da) * 2001-09-21 2007-03-19 Schering Corp Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP5137228B2 (ja) 2003-03-07 2013-02-06 メルク・シャープ・アンド・ドーム・コーポレーション 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
MXPA05009502A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
ES2318274T3 (es) 2003-03-07 2009-05-01 Schering Corporation Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia.
US20050096307A1 (en) * 2003-11-05 2005-05-05 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
AR047658A1 (es) 2004-02-03 2006-02-01 Cargill Inc Concentrado de proteinas y corriente acuosa con carbohidratos hidrosolubles
EP1921927A4 (en) * 2005-08-03 2011-11-23 Cargill Inc MAIZE PROTEIN CONCENTRATES
US20090209423A1 (en) * 2005-08-03 2009-08-20 Johannis Slabbekoorn Corn protein concentrates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4803266A (en) * 1986-10-17 1989-02-07 Taisho Pharmaceutical Co., Ltd. 3-Oxoalkylidene-2-azetidinone derivatives

Also Published As

Publication number Publication date
JPH0334966A (ja) 1991-02-14
OA09432A (fr) 1992-10-15
US5030628A (en) 1991-07-09
ZA899725B (en) 1990-09-26
AU628445B2 (en) 1992-09-17
EP0375527A1 (fr) 1990-06-27
FR2640621A1 (fr) 1990-06-22
PT92612A (pt) 1990-06-29
AU4691789A (en) 1990-06-21
FR2640621B1 (fr) 1992-10-30
DK641589D0 (da) 1989-12-18
CA2005759A1 (en) 1990-06-19
NZ231817A (en) 1992-03-26

Similar Documents

Publication Publication Date Title
DK641589D0 (da) N-aryl-azetidinoner, fremgangsmaade til deres fremstilling og deres anvendelse som elastaseinhibitorer
NO991815L (no) Oksadiazoler, fremgangsmÕter for deres fremstilling og deres anvendelse som medikamenter
DK373787A (da) Substituerede hydrazoner, fremgangsmaade til deres fremstilling og deres anvendelse som skadedyrsbekaempelsesmiddel
NO905090L (no) Interleukin-1-inhibitorer og fremgangsmaate til deres fremstilling.
DK660788D0 (da) 2,2-difluorcyklopropylethanderivater, fremgangsmaade til deres fremstilling og deres anvendelse som skadedyrsbekaempelsesmiddel
DK168786D0 (da) Hidtil ukendte dopaminderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel
DK409886A (da) Azolyl-cyclopropyl-ethanol-derivater, fremgangsmaade til deres fremstilling og deres anvendelse
DK530689D0 (da) Adenylcyclasederivater, fremgangsmaade til fremstilling deraf og deres anvendelse
DK686888D0 (da) Aminoketaler, deres fremstilling og deres anvendelse som fungicider
NO874786D0 (no) Optisk aktive gyrasehemmere, deres fremstilling og anvendelse som antibiotika.
DK651087A (da) Renininhibitorer iii, deres fremstilling og anvendelse
DK360189D0 (da) S-adenosyl-methionin-decarboxylase-inhibitorer, deres fremstilling og anvendelse
DK619989A (da) Dipeptidderivater, deres fremstilling og anvendelse som laegemidler
NO870639D0 (no) Benzimidazolderivater og deres anvendelse som fungicider.
DK358389A (da) 4-halogen-5-nitrothiazol-derivater, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
DK231089A (da) Substituerede azolthioethere, fremgangsmaade til fremstilling deraf samt deres anvendelse som skadedyrsbekaempelsesmiddel
DK278290D0 (da) Substituerede 6h-pyridooe4,3-baacarbazoler og deres anvendelse som laegemidler
DK202884A (da) Azolylethyl-benzyl-ether-derivater, fremgangsmaade til deres fremstilling og deres anvendelse som fungicider
DK390186A (da) Thiadiazolyloxyacetamider, fremgangsmaade til deres fremstilling og deres anvendelse som herbicider
NO901758L (no) Reninhemmende dipeptider, fremgangsmaate for deres fremstilling, midler som inneholder disse og deres anvendelse.
DK355389A (da) Hydroxyalkynyl-azolylderivater, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
DK461489A (da) Dimethylmaleinimider, deres fremstilling og anvendelse som herbicider
DK184686D0 (da) (aminoalkylthio)hydroxydibenzoxepiner, en fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
DK354688D0 (da) Benzooe5,6aacycloheptapyridiner, kompositioner og fremgangsmaader til deres anvendelse
DK366288D0 (da) Aminoketaler, deres fremstilling og deres anvendelse som fungicider

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment